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Preparation method for high-efficiency biocompatible radical photopolymerization visible light initiation system

A technology of biocompatibility and initiation system, applied in the preparation of high-efficiency biocompatible free radical photopolymerization visible light initiation system, in the field of visible light initiation system, it can solve problems such as poor, toxic biocompatibility, etc., and achieve co-initiation The effect of improved performance, improved antioxidant activity, and simple method

Active Publication Date: 2019-01-01
HAINAN NORMAL UNIV
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  • Summary
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the co-initiators used are mainly tertiary amine compounds, and the currently reported species are more or less toxic and have poor biocompatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A visible light initiating system that initiates hydrogel photocuring, its components are as follows:

[0034] The first component: camphorquinone 0.5%,

[0035] The second component: silk fibroin peptide 0.5%,

[0036] The visible light-initiated system was prepared according to the above-mentioned ratio, and the weight of the hydrogel precursor was 100%. The visible light-initiating system is added into an aqueous solution containing 30% acrylamide and mixed well to obtain a transparent and clear photocurable hydrogel precursor.

[0037] Photopolymerization reaction: The prepared photocurable hydrogel precursor solution is placed in a sealed transparent glass test tube and irradiated under a 150W metal halide lamp for 10 Min with a light intensity of about 20 mW / cm 2 . After the polymerization, methanol was added to precipitate the precipitate, which was collected by centrifugation, weighed after drying, and the polymerization conversion rate was calculated to eval...

Embodiment 2

[0039] A high-efficiency visible light initiating system for initiating photocuring of hydrogels, the components of which are as follows:

[0040] The first component: camphorquinone 0.5%,

[0041] The second component: 0.5% silk fibroin peptide after oxidation treatment,

[0042] Oxidation treatment method: Add 0.4 mL of 30% aqueous hydrogen peroxide solution to 8% silk fibroin peptide aqueous solution, let stand overnight at room temperature, and dry in a vacuum oven.

[0043] The preparation method of the hydrogel precursor is the same as in Example 1.

[0044] The photopolymerization reaction was the same as in Example 1.

Embodiment 3

[0046] A high-efficiency visible light initiating system for initiating photocuring of hydrogels, the components of which are as follows:

[0047] The first component: camphorquinone 0.5%,

[0048] The second component: 0.5% silk fibroin peptide after oxidation treatment,

[0049] Oxidation treatment method: add 1 mL of 30% hydrogen peroxide solution to 8% silk fibroin peptide aqueous solution, let it stand overnight at room temperature, and dry it in a vacuum oven.

[0050] The preparation method of the hydrogel precursor is the same as in Example 1.

[0051] The photopolymerization reaction was the same as in Example 1.

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Abstract

The invention relates to a visible light initiation system, especially to a preparation method for a high-efficiency biocompatible radical photopolymerization visible light initiation system, belonging to the technical field of photocuring preparation of medical hydrogels. The visible light initiation system is added into a photocured hydrogel precursor solution for preparation of a photocured hydrogel. On the basis that the total weight of the photocured hydrogel precursor solution is 100%, the system comprises, by weight, 0.5 to 1% of the first component--a photosensitizer, 0.5 to 1% of a second component--a coinitiator which is water-soluble sericin or silk peptide having undergone oxidation treatment by hydrogen peroxide, and / or 0.5 to 1% of a third component--a photosensitive synergist which is one selected from a group consisting of an iodonium salt, a sulfonium salt and a phosphonium salt.

Description

technical field [0001] The invention relates to a visible light triggering system, in particular to a preparation method of a high-efficiency biocompatible radical photopolymerization visible light triggering system, and belongs to the technical field of medical hydrogel photocuring preparation. Background technique [0002] In the photopolymerization or photocuring preparation of medical hydrogel materials, the most widely studied and applied technology is free radical photopolymerization preparation technology. One of its notable advantages is that it can precisely control the shape of the hydrogel, and even create highly complex simulated natural extracellular matrix at micro-nano resolution, which has unique advantages in the 3D printing of biomaterials. In the process of hydrogel preparation, bioactive substances, therapeutic molecules or cells can be coated in situ or later implanted, and are widely used in medical research, disease treatment, tissue repair and sustain...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F289/00C08F220/56C08F2/50
CPCC08F2/50C08F289/00C08F220/56
Inventor 南旭莹姚玉华吴明书陈光英
Owner HAINAN NORMAL UNIV
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