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Preparation method and application of a photoelectrochemical immunosensor based on tin dioxide/cadmium carbonate/cadmium sulfide

An immunosensor, tin dioxide technology, applied in scientific instruments, instruments, material analysis by electromagnetic means, etc., can solve problems such as unreported

Active Publication Date: 2021-08-20
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The synthesis of tin dioxide / cadmium carbonate / cadmium sulfide composites is the first time, and its application in photoelectrochemical immunosensors has not been reported

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 A preparation method of a photoelectrochemical immunosensor based on tin dioxide / cadmium carbonate / cadmium sulfide:

[0033] 1) The ITO conductive glass was ultrasonically cleaned with detergent, acetone, ethanol, 0.1 mol / L sodium hydroxide solution and ultrapure water for 0.5 h, and dried under nitrogen;

[0034] 2) Take 6 µL of tin dioxide / cadmium carbonate / cadmium sulfide solution and drop it on the conductive surface of ITO conductive glass, and let it dry at room temperature;

[0035] 3) Soak the above-modified electrode in thioglycolic acid solution with a concentration of 8 mmol / L for 0.5 h, and then wash it with ultrapure water;

[0036] 4) Drop 400 mmoL / L 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride solution and 200 mmoL / L N-hydroxy Mix 4 μL of succinimide solution. After incubating at room temperature for 0.5h, rinse the electrode surface with ultrapure water, and dry it to a wet film state at room temperature;

[0037] 5) Add dropwise...

Embodiment 2

[0040] Example 2 A preparation method of a photoelectrochemical immunosensor based on tin dioxide / cadmium carbonate / cadmium sulfide:

[0041] 1) The ITO conductive glass was ultrasonically cleaned with detergent, acetone, ethanol, 0.1 mol / L sodium hydroxide solution and ultrapure water for 0.5 h, and dried under nitrogen;

[0042] 2) Take 6 µL of tin dioxide / cadmium carbonate / cadmium sulfide solution and drop it on the conductive surface of ITO conductive glass, and let it dry at room temperature;

[0043] 3) Soak the above-modified electrode in a thioglycolic acid solution with a concentration of 3 mmol / L for 0.5 h, and then wash it with ultrapure water;

[0044] 4) Drop 10 mmol / L 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride solution and 20 mmol / L N-hydroxy Mix 4 μL of succinimide solution. After incubating at room temperature for 0.5h, rinse the electrode surface with ultrapure water, and dry it to a wet film state at room temperature;

[0045] 5) Add dropwi...

Embodiment 3

[0048] Embodiment 3 The preparation of tin dioxide / cadmium carbonate / cadmium sulfide solution:

[0049] Add 0.64 g of tin tetrachloride pentahydrate, 0.54 g of cadmium dichloride and 0.37 g of thiourea to 30 mL of ultrapure water in sequence and stir magnetically for 30 min; then, add ammonia solution with a concentration of 10.5 mol / L dropwise The pH value of the solution reached 7.5; the above solution was stirred for 10 min and then transferred to the reaction kettle, and reacted at 140 °C for 16 h; naturally cooled; the obtained product was washed with absolute ethanol and ultrapure water for 3 times; vacuum-dried at 40 °C for 12 h. h; Tin dioxide / cadmium carbonate / cadmium sulfide material was obtained after grinding; and configured into a tin dioxide / cadmium carbonate / cadmium sulfide aqueous solution with a concentration of 1 mg / mL.

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PUM

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Abstract

The invention relates to a preparation method and application of a photoelectrochemical immunosensor based on tin dioxide / cadmium carbonate / cadmium sulfide. The invention uses tin dioxide / cadmium carbonate / cadmium sulfide as the base material and irradiates with visible light to obtain photoelectric current. The energy bands of the three components of the base material are well matched, so that the photoelectric conversion efficiency is greatly improved, so as to obtain a large output signal. to be tested β ‑Different amounts of amyloid solution lead to different amounts of immune complexes, which in turn lead to different degrees of influence on photoelectric signals. Accordingly, the constructed sensor realizes the β ‑Amyloid detection. Its detection limit was 50 fg / mL.

Description

technical field [0001] The invention relates to a preparation method and application of a photoelectrochemical immunosensor based on tin dioxide / cadmium carbonate / cadmium sulfide, specifically a sensitive detection sensor prepared by using tin dioxide / cadmium carbonate / cadmium sulfide as a base material β -A photoelectrochemical immunosensor for amyloid, which belongs to the field of new functional materials and biosensing detection technology. Background technique [0002] β - Amyloid is a polypeptide that circulates in blood, cerebrospinal fluid, and interstitial fluid, and is the main component of senile plaques in the brains of Alzheimer's patients. nowadays, β - Amyloid is considered a biomarker for Alzheimer's disease. [0003] Researchers have used a variety of methods to achieve β - Detection of amyloid. For example, Liu et al. used an electrochemical method to realize the β -Accurate detection of amyloid in the concentration range of 90 pg / mL~677.1 ng / mL with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/68G01N33/543G01N27/327G01N27/416
CPCG01N27/3275G01N27/416G01N33/54366G01N33/6896
Inventor 魏琴张益峰魏东匡轩吴丹马洪敏胡丽华冯锐
Owner UNIV OF JINAN