A kind of photothermal preparation based on biliverdin, its preparation method and application

A technology of biliverdin and preparations, applied in the field of photothermal nanomedicine, to achieve high stability, good photothermal conversion effect, and clear metabolic mechanism
CN109224073BActive Publication Date: 2021-05-07INST OF PROCESS ENG CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Ā· China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF PROCESS ENG CHINESE ACAD OF SCI
Publication Date
2021-05-07

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Abstract

The present invention relates to a photothermal preparation based on biliverdin, including: biliverdin, biliverdin gel, biliverdin-metal chelate, biliverdin-biomolecular complex, biliverdin-biomolecule-metal functional assembly. The prepared photothermal preparation has the following advantages: 1) near-infrared absorption and good tissue penetration depth; 2) high photothermal conversion efficiency; 3) biocompatibility and clear metabolic mechanism. The preparation of this series of biliverdin-based photothermal preparations is of great significance for the development of multifunctional phototherapeutic drugs, and has great application potential in tumors, skin diseases (such as pigmentary diseases), and vascular diseases.
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Description

technical field

[0001] The invention belongs to the field of photothermal nano medicine, and in particular relates to a photothermal preparation based on biliverdin and having near-infrared absorption, a preparation method and application thereof. Background technique

[0002] Photothermal therapy is a new type of disease (such as tumor, skin, vascular disease, etc.) treatment. This method is easy to operate, highly targeted, non-invasive to normal tissues, and can effectively inhibit recurrence. In the process of photothermal therapy, photothermal preparations can capture light energy and convert it into heat, and then, local hyperthermia causes irreversible apoptosis of cells, thereby achieving the effect of photothermal therapy. At the same time, when the pulsed laser is irradiated to the diseased tissue, the photoacoustic signal will be generated in the light-absorbing area of ā€‹ā€‹the tissue, thereby realizing the photoacoustic imaging of the lesion. New methods for earl...

Claims

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