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A kind of photothermal preparation based on biliverdin, its preparation method and application

A technology of biliverdin and preparations, applied in the field of photothermal nanomedicine, to achieve high stability, good photothermal conversion effect, and clear metabolic mechanism

Active Publication Date: 2021-05-07
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the development of photothermal preparations based on biliverdin has far-reaching significance in the field of photothermal therapy. At present, there is no public report

Method used

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  • A kind of photothermal preparation based on biliverdin, its preparation method and application
  • A kind of photothermal preparation based on biliverdin, its preparation method and application
  • A kind of photothermal preparation based on biliverdin, its preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0076] Weigh 10mg of biliverdin powder, dissolve in 0.1M NaOH solution, the final concentration is 0.2mgmL -1 . That is, the photothermal preparation biliverdin monomolecule solution, its ultraviolet absorption diagram is as follows figure 1 shown. It shows a broad absorption peak in the near-infrared region of 600-900nm.

Embodiment 2

[0078] Weigh 10 mg of biliverdin powder, dissolve it in 0.1 M NaOH solution, and finally obtain a concentration of 0.2 mg mL -1 The biliverdin monomolecule solution was tested under a 730nm laser, and the laser power was set at 0.3W cm -2 . Its heating curve is as figure 2 shown.

Embodiment 3

[0080] Weigh 8 mg of biliverdin powder and dissolve it in 50 uL of DMSO solution, mix well with ultrasonic assistance, add 950 uL ultrapure water, and mix well. The pH value of the newly prepared mixed solution was adjusted to 6.9, and it was aged at 4°C in the dark for 8 hours to obtain a concentration of 8mg mL -1 The biliverdin gel, the resulting gel physical picture is as follows image 3 As shown, it is in a uniform state without flow after inversion.

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Abstract

The present invention relates to a photothermal preparation based on biliverdin, including: biliverdin, biliverdin gel, biliverdin-metal chelate, biliverdin-biomolecular complex, biliverdin-biomolecule-metal functional assembly. The prepared photothermal preparation has the following advantages: 1) near-infrared absorption and good tissue penetration depth; 2) high photothermal conversion efficiency; 3) biocompatibility and clear metabolic mechanism. The preparation of this series of biliverdin-based photothermal preparations is of great significance for the development of multifunctional phototherapeutic drugs, and has great application potential in tumors, skin diseases (such as pigmentary diseases), and vascular diseases.

Description

technical field [0001] The invention belongs to the field of photothermal nano medicine, and in particular relates to a photothermal preparation based on biliverdin and having near-infrared absorption, a preparation method and application thereof. Background technique [0002] Photothermal therapy is a new type of disease (such as tumor, skin, vascular disease, etc.) treatment. This method is easy to operate, highly targeted, non-invasive to normal tissues, and can effectively inhibit recurrence. In the process of photothermal therapy, photothermal preparations can capture light energy and convert it into heat, and then, local hyperthermia causes irreversible apoptosis of cells, thereby achieving the effect of photothermal therapy. At the same time, when the pulsed laser is irradiated to the diseased tissue, the photoacoustic signal will be generated in the light-absorbing area of ​​the tissue, thereby realizing the photoacoustic imaging of the lesion. New methods for earl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K31/409A61P35/00A61P17/00A61P9/14A61K49/00A61K49/22
CPCA61K31/409A61K41/0052A61K49/0002A61K49/22A61P9/14A61P17/00A61P35/00
Inventor 闫学海邢蕊蕊邹千里李淑坤赵鲁阳沈桂芝
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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