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A kind of method for extracting high-purity vitexin and isovitexin from sandalwood leaves

A technology of isovitexin and sandalwood leaves, which is applied in the field of extracting high-purity vitexin and isovitexin, can solve the problems of low product yield, long production cycle, and high experimental cost, and achieve high extraction efficiency and production The effect of short cycle time and simple preparation method

Active Publication Date: 2020-10-20
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method has the problems of high experimental cost, complicated operation, and low recovery rate.
[0004] In summary, there are many existing methods for extracting vitexin and isovitexin, but generally speaking, the existing methods are relatively old, with long production cycle, high cost, low product yield and low purity. The problem

Method used

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  • A kind of method for extracting high-purity vitexin and isovitexin from sandalwood leaves
  • A kind of method for extracting high-purity vitexin and isovitexin from sandalwood leaves
  • A kind of method for extracting high-purity vitexin and isovitexin from sandalwood leaves

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Effect test

Embodiment 1

[0033] A method for extracting high-purity vitexin and isovitexin from sandalwood leaves, specifically comprising the following steps:

[0034] (1) Extraction: Dry the sandalwood leaves at 30°C until the water content is 8.9%, pulverize, add methanol with a volume fraction of 45% according to the ratio of solid to liquid 1:12 and stir for extraction, the extraction time is 1h; filter to obtain the filtrate, repeat Extract 3 times, combine filtrate;

[0035] (2) Decolorization: decolorize the extract with 1.5% gac of sandalwood leaf weight, the decolorization temperature is 35°C, and the decolorization time is 2h;

[0036] (3) Extraction: Concentrate the above-mentioned alcohol extraction and decolorization liquid under reduced pressure to one-tenth of the original volume, use 0.3 times the volume of petroleum ether to extract 2 times to remove part of the fat-soluble components and 1.5 times the volume of ethyl acetate to extract 3 times , and finally collect the resulting et...

Embodiment 2

[0042] A method for extracting high-purity vitexin and isovitexin from sandalwood leaves, comprising the following steps:

[0043] (1) Alcohol extraction: dry the sandalwood leaves at 35°C until the moisture content is 11.2%, pulverize, stir and extract with 50% ethanol, the ratio of solid to liquid is 1:15, and the extraction time is 1.5h; filter to obtain the filtrate, repeat Extract 2 times, combine filtrate;

[0044] (2) Decolorization: decolorize the extract with 2.5% diatomaceous earth of sandalwood leaf weight, the decolorization temperature is 45°C, and the decolorization time is 2h;

[0045] (3) Extraction: Concentrate under reduced pressure the alcohol extraction and decolorization solution obtained in step (2) to one-tenth of the original volume, use 0.5 times of petroleum ether to extract 1 time and 3 times the volume of ethyl acetate to extract 4 times, and finally Obtain ethyl acetate extract;

[0046] (4) Concentration and centrifugation: collect the ethyl ace...

Embodiment 3

[0051] A method for extracting high-purity vitexin and isovitexin from sandalwood leaves, comprising the following steps:

[0052] (1) Alcohol extraction: dry the sandalwood leaves at 37°C until the water content is 10.3%, pulverize, stir and extract with 55% ethanol, the ratio of solid to liquid is 1:20, and the extraction time is 1.5h; filter to obtain the filtrate, Repeat the extraction 3 times and combine the filtrates;

[0053] (2) Decolorization: decolorize the extract with a decolorizer of 1.8% of sandalwood leaf weight, the decolorization temperature is 45°C, and the decolorization time is 1.5h;

[0054] (3) Extraction: Concentrate the alcohol extraction and decolorization liquid under reduced pressure to one-tenth of the original volume, use 1 times of petroleum ether to extract 2 times and 3.5 times of ethyl acetate to extract 3 times, and finally obtain ethyl acetate extract .

[0055] (4) Concentration and centrifugation: Concentrate and freeze-dry the obtained e...

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Abstract

The invention provides a method for extracting high-purity vitexin and isovitexin from santati album leaves. The method comprises the steps: repeatedly extracting dried and smashed santati album leaves through ethyl alcohol or methyl alcohol for twice to three times, combining filtrates, decolorizing through a decolorizing agent, performing vacuum concentration and sequentially utilizing petroleumether and ethyl acetate to extract concentrate for twice to three times; combining ethyl acetate extract liquor, concentrating, freeze drying, fully dissolving in water bath and centrifuging to divide into precipitate and supernatant; centrifuging the precipitate in 75 to 85 DEG C water bath and freeze drying the obtained precipitate to obtain the vitexin; concentrating the supernatant and utilizing a cooling crystallization mode to obtain isovitexin. The purity of the vitexin and the isovitexin prepared by the method is higher than 98%; furthermore, the method has the advantages of being simple and convenience in operation, low cost and high extracting efficiency; the obtained product has a high purity, and large-scale production is achieved.

Description

technical field [0001] The invention belongs to the field of plant extraction, and more specifically relates to a method for extracting high-purity vitexin and isovitexin from sandalwood leaves. Background technique [0002] Sandalwood (SantaLum aLbum L.), also known as true sandalwood, white sandalwood, Zhentan, etc., is a semi-parasitic evergreen small tree of the genus Sandalwood in the family Sandalaceae. Native to southern India, Indonesia and other places, it is an important economic tree species integrating medicine, spices, Buddhist supplies, fine handicrafts and excellent carving materials. Vitexin and isovitexin are two flavonoids with high content in sandalwood leaves, belonging to carbon glycoside flavonoids, with stable structure and not easy to degrade. It has antitumor, blood pressure lowering, antispasmodic, antibacterial and other physiological activities. It is mainly used to treat cardiovascular diseases, and can also be used to prepare anticancer and pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D407/04
CPCC07D407/04
Inventor 贺丽苹余雪婷周铭林刘耀慧
Owner SOUTH CHINA AGRI UNIV
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