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Anti-tumor sweet potato active monomer, anti-tumor sweet potato extract as well as preparation methods and application of anti-tumor sweet potato active monomer and anti-tumor sweet potato extract

An anti-tumor activity and anti-tumor technology, applied in the field of medicinal chemistry, can solve the problems of polluting the environment, wasting resources, difficult separation and identification of active monomers, etc.

Active Publication Date: 2019-01-18
重庆观妙生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, on the one hand, the development and utilization of sweet potato is still primary processing——to generate sweet potato starch. (commonly known as yellow pulp or starch wastewater) is lost together, which not only pollutes the environment, but also wastes resources; on the other hand, it is difficult to separate and identify active monomers in sweet potatoes, and it is still impossible to determine which components have anti-tumor effects.

Method used

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  • Anti-tumor sweet potato active monomer, anti-tumor sweet potato extract as well as preparation methods and application of anti-tumor sweet potato active monomer and anti-tumor sweet potato extract
  • Anti-tumor sweet potato active monomer, anti-tumor sweet potato extract as well as preparation methods and application of anti-tumor sweet potato active monomer and anti-tumor sweet potato extract
  • Anti-tumor sweet potato active monomer, anti-tumor sweet potato extract as well as preparation methods and application of anti-tumor sweet potato active monomer and anti-tumor sweet potato extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 sweet potato anti-tumor extract

[0047] Step 1: at 100°C, add 0.01% of the weight of calcium sulfate to 100L sweet potato mother liquor, stir evenly, cool to 80°C, centrifuge, and vacuum dry at 60°C to obtain sweet potato crude extract;

[0048] Step 2: add 10% ethanol (weight / weight) of its weight 1 times amount to step 1 gained sweet potato crude extract, stir 1min, filter, filter residue dissolves with its weight 1 times amount of 10% ethanol, filters, repeats 2 The second time, the filtrates were collected and combined, concentrated, and dried to obtain the sweet potato anti-tumor extract, wherein the total content of sitosterol, the compound shown in formula I and the compound shown in formula II was 11.5%.

Embodiment 2

[0049] The preparation of embodiment 2 sweet potato anti-tumor extract

[0050] Step 1: At 50°C, add aluminum sulfate with a weight of 1% of the weight of the mother liquor to 100L of sweet potato starch mother liquor, stir evenly, cool to 20°C, centrifuge, and vacuum dry at 60°C to obtain a sweet potato crude extract;

[0051] Step 2: Add 50% propanol (weight / weight) of 5 times of its weight to the sweet potato crude extract obtained in step 1 and stir for 20min, filter, filter residue dissolves with 50% propanol of 5 times of its weight, filter, repeat Four times, the filtrates were collected and combined, concentrated, and dried to obtain the sweet potato anti-tumor extract, wherein the total content of sitosterol, the compound represented by formula I and the compound represented by formula II was 17.5%.

Embodiment 3

[0052] The preparation of embodiment 3 sweet potato anti-tumor extract

[0053] Step 1: At 70°C, add 0.1% acetic acid by the weight of the mother liquor to 100L sweet potato starch mother liquor, stir evenly, cool to 20°C, centrifuge, and vacuum dry at 60°C to obtain sweet potato crude extract;

[0054] Step 2: Add 80% acetone (weight / weight) of 3 times of its weight to the sweet potato crude extract obtained in step 1 and stir for 10 min, filter, dissolve the filter residue with 80% propanol of 3 times of its weight, filter, repeat 3 times Once, the filtrates were collected and combined, concentrated, and dried to obtain the sweet potato anti-tumor extract, wherein the total content of sitosterol, the compound shown in formula I and the compound shown in formula II was 15.4%.

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Abstract

The invention belongs to the field of medical chemistry and particularly relates to an anti-tumor sweet potato active monomer, anti-tumor sweet potato extract as well as preparation methods and application of the anti-tumor sweet potato active monomer and the anti-tumor sweet potato extract. The anti-tumor sweet potato active monomer has remarkable inhibitory activity for tumor cell growth, and inhibition ratio on MCF-7 cells and HCT8 cells reaches 55% or higher under administration concentration of 10 mg / L; the anti-tumor sweet potato extract also has remarkable inhibitory activity for tumorcell growth, and inhibition ratio on growth of MCF-7 cells and HCT8 cells reaches 70% or higher under concentration of 100 ppm, and especially for the anti-tumor sweet potato extract further subjectedto column chromatographic purification, the inhibition ratio on growth of MCF-7 cells and HCT8 cells reaches 85% or higher under concentration of 100 ppm.

Description

technical field [0001] The invention belongs to the field of medicinal chemistry, and specifically relates to a sweet potato anti-tumor active monomer, a sweet potato anti-tumor extract and a preparation method and application thereof. Background technique [0002] Tumor is a malignant disease that seriously threatens human health. In my country, tumor has become the first cause of death, and the morbidity and mortality are still rising. In 2015, there were 4.292 million new cancer cases in China, which is equivalent to an average of new cases every day. 12,000 cases of cancer, and 2.814 million deaths, equivalent to an average of 7,500 people die of cancer every day. Finding and developing anti-tumor drugs with definite curative effect and less toxic and side effects has always been a hot spot and difficulty in drug innovation research and development. Due to the unique advantages of traditional Chinese medicine, extracting safe and effective parts from traditional Chinese ...

Claims

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Application Information

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IPC IPC(8): C07J17/00A61K31/704A61K31/575A61P35/00
CPCA23V2002/00A61K31/575A61K31/704A61K36/8945A23L33/105C07J17/005A61K2300/00A23V2200/308
Inventor 叶小利李学刚李滟临李亚松
Owner 重庆观妙生物科技有限公司