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Application of Wnt5a as diagnosis marker of peri-implantitis

A technology for diagnosing markers and implants, applied in biological tests, material inspection products, measuring devices, etc., can solve the problems of patients missing early treatment and difficult early diagnosis.

Inactive Publication Date: 2019-01-18
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, it is difficult to carry out early diagnosis by this method, which often makes patients miss the opportunity of early treatment.

Method used

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  • Application of Wnt5a as diagnosis marker of peri-implantitis
  • Application of Wnt5a as diagnosis marker of peri-implantitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Western-blot detection of Wnt5a expression differences in peri-implant tissues in patients with peri-implantitis and normal implant populations

[0016] 1. Research objects: 8 patients with peri-implantitis were collected, 4 males and 4 females, aged 38-61 years. Inclusion criteria: The diagnostic criteria were in line with the clinical diagnostic criteria for peri-implantitis (refer to "Schwarz F, Sculean A, Rothamel D, Schwenzer K, Georg T, Becker J. Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis : a pilot study. Clin Oral Implants Res 2005; 16:44-52.”). Exclusion criteria: (1) patients who received oral or systemic decontamination (rinse or antibiotics) treatment within the past six months; (2) patients with uncontrolled periodontal disease; (3) patients with systemic disease; (4) Smokers; (5) Pregnant women and nursing mothers. This study was approved by the Hospital Ethics Committee and all patients signed informed ...

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Abstract

The invention belongs to the field of molecular diagnosis technology, and discloses application of Wnt5a as a diagnosis marker of peri-implantitis. According to the invention, it is provided that a risk of having the peri-implantitis by a subject can be judged or status of the peri-implantitis can be determined through detecting an expression level of Wnt5a which is in surrounding tissue of an implant or in fluid surrounding the implant. Compared with traditional diagnosis methods of the peri-implantitis, use of Wnt5a as the protein marker for diagnosis of the peri-implantitis has the significant advantages of timeliness, specificity, sensitivity and the like, and a patient can know a disease risk in an early stage of appearing of the peri-implantitis, and take appropriate preventive and therapeutic measures for a risk degree.

Description

technical field [0001] The invention belongs to the technical field of molecular diagnosis, and specifically relates to a new application of Wnt5a. Background technique [0002] With the continuous development of oral implant technology, implant restoration has gradually occupied an increasingly important position in the restoration of various dentition defects and missing dentition. Implant dentures are popular for their unique advantages such as comfort, beauty, stability, strong chewing function, and no damage to adjacent teeth. However, the phenomenon of implant failure also occurs from time to time, and the main reasons can be divided into two categories: biological complications and mechanical complications. Among them, the most common biological complication is peri-implantitis (Graziani F, Figuero E, Herrera D. Systematic review of quality of reporting, outcome measurements and methods to study efficacy of preventive and therapeutic approaches to peri-implant diseas...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6827G01N33/6893
Inventor 张倩车成业
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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