Compound composition based on clotrimazole for gynecology department
A composition and clotrimazole technology are applied in the field of gynecological compositions to achieve good therapeutic effect and improve bacteriostatic effect.
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Embodiment 1
[0012] Pharmacological Example 1, Preparation of drug-resistant strains
[0013] Preparation
[0014] 1) Candida albicans (Candida albicans) (Code: ATCC10231) was used as the standard strain, and the standard strain of Candida albicans was continuously transplanted twice on Sabouraud agar (SDA) medium (cultivation temperature 35°C), and cultivated for 24 hours Finally, select 5 bacterial colonies with a diameter greater than 1 cm and shake them in 5 mL sterile normal saline for 15 seconds to make a bacterial suspension. 5×10 5 CFU / mL.
[0015] 2) Detect the minimum inhibitory concentration (MIC) of clotrimazole against Candida albicans, according to the CLSIM38-2 protocol, the quality control strain is Candida parapsilosis (ATCC 22019); the MIC result of the standard strain of Candida albicans is negative Compared with the control group, the minimum concentration that can significantly inhibit the growth of fungi (about 80%) is the minimum inhibitory concentration
[0016]...
preparation Embodiment
[0040] In the preparation examples, the preparation is made into a gel, and the content specification of clotrimazole in all gels is unified as 50mg / 5g
[0041] Example 1
[0042] Clotrimazole 1g, Timosaponin B2 0.25g
[0043] Carbomer 941 1g, glycerol 10g Tween 80 1g
[0044] Ethylparaben 0.1g Purified water added to 100g
[0045] Preparation method
[0046] 1) Carbomer is soaked overnight with an appropriate amount of purified water, fully stirred until it is completely swollen into a uniform gel-like polymer, then added ethylparaben and the main ingredient and mixed evenly to obtain a mixed solution 1)
[0047] 2) Mix glycerol and Tween 80 and add the mixed solution 1) Stir well, add an appropriate amount of purified water to 80g, adjust the pH to 4-4.5 with triethanolamine, make up the remaining water and stir well to obtain a transparent gel .
Embodiment 2
[0049] Clotrimazole 1g, Timosaponin B2 0.5g
[0050] Carbomer 941 1g, glycerol 10g Tween 80 1g
[0051] Ethylparaben 0.1g Purified water added to 100g
[0052] Preparation method
[0053] 1) Carbomer is soaked overnight with an appropriate amount of purified water, fully stirred until it is completely swollen into a uniform gel-like polymer, then added ethylparaben and the main ingredient and mixed evenly to obtain a mixed solution 1)
[0054] 2) Mix glycerol and Tween 80 and add the mixed solution 1) Stir well, add an appropriate amount of purified water to 80g, adjust the pH to 4-4.5 with triethanolamine, make up the remaining water and stir well to obtain a transparent gel .
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