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Compound antibacterial preparation for lactation period as well as preparation method and application thereof

A lactation, compound technology, applied in the directions of antibacterial drugs, pharmaceutical formulations, emulsion delivery, etc., can solve the problems of not considering the dispersion of preparations, poor dispersion, etc., to shorten the time of drug effect, easy to use, and degree of dispersion. good effect

Active Publication Date: 2019-03-08
FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the relevant studies do not consider the dispersibility of preparations in milk, such as CN201310664982.X, CN201110432684.9, CN201610105590.3, etc., and the dispersion in milk is relatively poor

Method used

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  • Compound antibacterial preparation for lactation period as well as preparation method and application thereof
  • Compound antibacterial preparation for lactation period as well as preparation method and application thereof
  • Compound antibacterial preparation for lactation period as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1, the screening of emulsifier in the lactation period compound antibacterial preparation

[0039] The composition of the prescription is shown in Table 2. In Table 2, the active ingredient of the drug is composed of rifaximin and cefquinome, and the mass ratio of the two is 1:2; the suspending agent is glyceryl monostearate; the surfactant is Tween- 80 and Span-80; the vegetable oil is soybean oil.

[0040] The preparation method is as follows:

[0041] Take an appropriate amount (4g) of sterile vegetable oil and heat it to 60-80°C, add the above-mentioned suspending agent and continue heating and stirring for 30-60 minutes, then cool to 36-42°C, add an emulsifier, stir until it melts, then add the above-mentioned surfactant and stir Put the active ingredient of the above-mentioned sterile drug after uniformity, and finally add the above-mentioned sterile vegetable oil to 8 mg, and grind it in a colloid mill for at least 15 minutes to obtain.

[0042] The...

Embodiment 2

[0052] Embodiment 2, a kind of prescription and preparation method of lactation period compound antibacterial preparation

[0053]

[0054]

[0055] The preparation method is as follows:

[0056] Take an appropriate amount (4g) of sterile corn oil and heat it to 60-80°C, add glyceryl monostearate and continue heating and stirring for 30-60 minutes, then cool to 36-42°C, add anhydrous lanolin, stir until it melts, and then add Stir Tween-80 and Span-80 evenly, add sterile drug micropowder, and finally add sterile corn oil to 8 mg, and grind in a colloid mill for at least 15 minutes. The properties of the obtained preparation are orange-red to dark red oily suspension.

[0057] The sedimentation volume ratio, redispersibility, dispersibility in milk and sterility test of the above products all meet the quality standards for breast injections.

Embodiment 3

[0058] Embodiment 3, a kind of prescription and preparation method of lactation period compound antibacterial preparation

[0059]

[0060] The preparation method is as follows:

[0061] Take carrageenan and stir in an appropriate amount of water at 65-80°C until it dissolves for later use, take an appropriate amount (4g) of sterile corn oil and heat it to 36-42°C, add anhydrous lanolin, add Tween-80, Span-80 and After the dissolved carrageenan solution is stirred evenly, add sterile drug micropowder, add sterile corn oil to 8 mg, grind it in a colloid mill for at least 15 minutes, heat at 121°C for 30 minutes to remove water, and then obtain the solution. The properties of the obtained preparation are orange-red to dark red oily suspension.

[0062] The sedimentation volume ratio, redispersibility, dispersibility in milk and sterility test of the above products all meet the quality standards for breast injections.

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Abstract

The invention discloses an antimicrobial composition and a preparation containing the same. The antibacterial composition comprises rifaximin and cephalosporin antibiotics at a mass ratio of 1 to 0.5-5. The compound antibacterial preparation comprises the following components by mass percentage: 2-10% of the antibacterial composition, 2-6% of a suspending agent, 2-10% of anhydrous lanolin, 5-20% of a surfactant and 54-89% of vegetable oil. The recombination of two antibacterial drugs achieves a synergistic effect, so that the compound antibacterial preparation not only has a broad-spectrum effect, but also has a good antibacterial effect on pathogenic bacteria that are difficult to prevent and capable of invading deep tissues of breasts, and is efficient, comprehensive and safe. A principle of selection of the excipients used in the antibacterial preparation is that the dispersion in milk is good, so that the time during which a drug takes effect is shortened and the drug utilization rate is improved.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, and in particular relates to a compound antibacterial preparation for treating lactating cow mastitis, a preparation method and application thereof. Background technique [0002] In recent years, with the rapid development of social economy, the food structure of residents has changed significantly. Under the influence of western nutrition, the consumption of dairy products continues to increase. Cow mastitis is one of the most common diseases affecting the dairy industry, causing huge economic losses. It also has the characteristics of high incidence and high proportion of recessive mastitis. According to the monitoring of the incidence of dairy cow mastitis in dairy farms, it is mainly concentrated in the early lactation and dry lactation period, but the occurrence of mastitis during lactation causes more serious economic losses including milk abandonment and culling of sick cows. According to ...

Claims

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Application Information

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IPC IPC(8): A61K31/437A61K45/06A61K31/546A61K9/10A61K47/44A61K47/14A61K47/36A61K47/38A61P31/04A61P15/14
CPCA61K9/10A61K31/437A61K31/546A61K45/06A61K47/14A61K47/36A61K47/38A61K47/44A61P15/14A61P31/04A61K2300/00
Inventor 李秀波徐飞蒋玲玉刘义明陈孝杰
Owner FEED RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES
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