Metal-porphyrin nano-particles with sonodynamic therapy effect as well as preparation method and application thereof

A sonodynamic therapy and nanoparticle technology, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve poor therapeutic effect, poor therapeutic effect, side effects and drug resistance To achieve the effect of increasing accumulation, reducing non-specific distribution, and improving tumor-specific distribution

Active Publication Date: 2019-03-08
XIAMEN UNIV
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Problems solved by technology

At present, the treatment methods for liver cancer mainly include surgical resection, radiofrequency ablation, chemotherapy, transarterial chemoembolization (TACE), etc., but all of them have great limitations.
Less than 40% of patients are suitable for surgical resection and radiofrequency ablation; chemotherapy has serious

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  • Metal-porphyrin nano-particles with sonodynamic therapy effect as well as preparation method and application thereof
  • Metal-porphyrin nano-particles with sonodynamic therapy effect as well as preparation method and application thereof
  • Metal-porphyrin nano-particles with sonodynamic therapy effect as well as preparation method and application thereof

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Embodiment Construction

[0055] In order to make the purpose, technical solutions and advantages of the present disclosure clearer, the present disclosure will be further described in detail below in conjunction with specific embodiments and with reference to the accompanying drawings.

[0056] The invention provides a kind of preparation method of porphyrin metal-organic nanoparticles, comprising the following steps:

[0057] a) dissolving ferric chloride and porphyrin in deionized water, stirring at room temperature (1000rpm) for 24h;

[0058] b) Transfer the above solution into a 30KD ultrafiltration tube, and centrifuge (4000rpm) at room temperature for 15min;

[0059] c) Take the precipitate and blow and mix with 3mL of deionized water, put it into an ultrafiltration tube and centrifuge (4000rpm) for 15-25min, repeat this step 3 times;

[0060] d) Resuspending the above precipitate with 3 mL of deionized water to form initially prepared nanoparticles;

[0061] e) First prepare the dimer of DPA—...

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Abstract

The invention discloses metal-porphyrin nano-particles with sonodynamic therapy effects as well as a preparation method and the application thereof. Firstly, sulfonate ions and iron ions (Fe3<+>) of porphyrin are combined, and the metal-porphyrin nano-particles are formed by self-assembly. A nanostructure has more excellent sonodynamic therapy properties and molecular image monitoring and tracingproperties. In the invention, targeted peptide-modified Zn(II)-dimethylpyridamine dimer (Bis(DPA-Zn)-RGD) is prepared. Further, bis(DPA-Zn)-RGD with tumor targeting ability is modified on the surfaceby applying the ability to combine the sulfonate ions on the nano-TPPS surface with the Zn(II)-dimethylpyridamine (DPA-Zn). In combination with the surface-modified nanostructure and phosphate ions ofsiRNA, the siRNA can be loaded.

Description

technical field [0001] The invention relates to a metal-porphyrin nanometer particle modified by targeting polypeptide, a preparation method and an application thereof. Background technique [0002] Liver cancer is one of the most common clinical tumors, ranking sixth in the incidence of malignant tumors and third in the mortality rate, with about 500,000 new cases every year. Currently, the treatment methods for liver cancer mainly include surgical resection, radiofrequency ablation, chemotherapy, transarterial chemoembolization (TACE), etc., but all of them have great limitations. Less than 40% of patients are suitable for surgical resection and radiofrequency ablation; chemotherapy has serious side effects and drug resistance, and the treatment effect is poor; TACE has many contraindications and adverse reactions. Photodynamic therapy (PDT) uses non-toxic light and photosensitizers to generate reactive oxygen species (ROS) to kill tumor cells, which has attracted great a...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/64A61K47/54A61K41/00A61K31/7088A61P35/00
CPCA61K31/7088A61K41/0028A61K47/546A61K47/64A61K47/6929A61P35/00A61K2300/00
Inventor 刘刚朱靖楚成超李东升石业思张阳任恩
Owner XIAMEN UNIV
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