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A kind of preparation method of photothermal gold nanomaterial

A gold nanometer and gold nanocages technology, which is applied in the field of gold nanomaterial preparation, can solve problems such as loss of silver loading, and achieve the effects of good uniformity, small particle size, and good tissue permeability

Active Publication Date: 2022-07-29
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the existing metal nanocages realize the photothermal response to near-infrared lasers by increasing the degree of hollowing inside, which loses its silver loading.

Method used

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  • A kind of preparation method of photothermal gold nanomaterial
  • A kind of preparation method of photothermal gold nanomaterial
  • A kind of preparation method of photothermal gold nanomaterial

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation method of gold nano-cages, comprising the steps:

[0030] (1) Preparation of template silver nanocubes of gold nanocages: Weigh 0.192g silver nitrate, 0.11g sodium hydrosulfide and 0.1g polyvinylpyrrolidone and dissolve them in 4mL, 5mL and 5mL of ethylene glycol respectively. After the dissolution is completed, immediately place the silver nitrate solution and the sodium hydrosulfide solution into -20°C and freeze for at least half an hour for later use. The ethylene glycol solution was heated to 150°C in an oil bath, and nitrogen (100 mL min) was passed through while heating. -1 ), and at the same time, the stirring speed was 1000r min with a magnetic sub -1 , 2.5mL of polyvinylpyrrolidone solution and 120ul of sodium hydrosulfide solution were added successively after 30min. Continue heating and stirring. After 30 minutes, the nitrogen valve was closed, the conduit for nitrogen gas was pulled out, and 850 ul of silver nitrate solution...

Embodiment 2

[0033] Example 2: Stability test of silver nanocubes and gold nanocages. The same amount of silver nanocubes and gold nanocages were diluted with 50% ethanol aqueous solution and pure aqueous solution respectively, and placed in 2mL centrifuge tubes. placed for 5 days. Watch for changes. Simultaneously measure its spectrum. The stability test results of silver nanocubes in ultrapure water and ethanol aqueous solution, and the stability test results of gold nanocages in ultrapure water and ethanol aqueous solution are as follows, respectively. Image 6 and Figure 7 Shown: the active ingredients of silver nanocubes and gold nanocages in pure aqueous solution have obvious changes, and the active ingredients in pure water are significantly reduced compared with ethanol aqueous solution.

Embodiment 3

[0034] Example 3: Glutathione-induced aggregation of gold nanocages and photothermal evaluation experiments

[0035] Using phosphate buffer as a solvent, a glutathione solution with a concentration of 10 mM was prepared for use. Dilute the gold nanocages to 40 μg / mL with deionized water. The two were mixed at a volume ratio of 1:1, and their UV-Vis absorption spectra were recorded every 6 min for 1 h. The results obtained are as image 3 Shown: within 1 h, the absorption peaks in the visible range begin to weaken, and the absorption peaks in the near-infrared and near-infrared regions gradually increase.

[0036] According to the UV-Vis absorption spectrum, the sample was irradiated with 808nm laser for 10min at 30min, 50min, and 90min after the gold nanocages were mixed with glutathione, and the laser power was 1W / cm 2 . At the same time, an infrared camera was used to record the temperature rise of the sample during the process every 1 min. The results obtained are show...

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Abstract

The invention discloses a preparation method of photothermal gold nanomaterials. First, silver nanocubes are mixed with an equal volume of acetone solution, centrifuged, the supernatant is discarded, ethanol aqueous solution is added to the precipitate, the precipitate is completely dissolved, and centrifugation is performed again. , washed with ethanol aqueous solution, and the supernatant was made up to volume with ethanol ultrapure water to obtain a silver nanocube solution, which was used for later use; take the polyvinylpyrrolidone aqueous solution, in a water bath environment, add the silver nanocube solution, stir, and then dropwise add Chlorauric acid aqueous solution, when the solution turns purple, stop dripping, the reaction solution is cooled to room temperature, add excess sodium chloride, stir well, collect the supernatant, wash with ethanol aqueous solution, and ultrapure the supernatant with ethanol Dilute to volume with water; take the purple solution, dilute it with deionized water, add an equal volume of glutathione solution, and mix well. The photothermal nanomaterial prepared by the invention has properties such as photothermal properties.

Description

technical field [0001] The invention relates to a method for preparing gold nanomaterials, in particular to a method for preparing gold nanomaterials with photothermal effect. Background technique [0002] In recent years, metal nanocages have been widely studied in the early diagnosis and treatment of cancer due to their superior biocompatibility, optical properties, in vivo drug transport, and sustained drug release at the lesion site. Such a size and the degree of internal hollowing have the advantages of good drug-carrying capacity, photothermal release of drugs or photothermal anti-cancer. It is of great significance for early diagnosis of tumors and then interventional therapy. [0003] However, the existing metal nanocages achieve photothermal response to near-infrared lasers by increasing the degree of hollowing inside them, losing their silver loading. Herein, the present invention proposes a method to endow the gold nanocages with photothermal response to near-in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24A61K41/00A61P35/00B82Y40/00
CPCB22F9/24B82Y40/00A61K41/0052A61P35/00
Inventor 姜晖秦肇建杜天宇张佳蕾谢孟阳陈芸王雪梅
Owner SOUTHEAST UNIV
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