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A nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen and its preparation and application

A near-infrared light and nano-light technology, used in photodynamic therapy, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of hypoxia and penetration depth in tumor tissue, etc. Achieve the effect of good biocompatibility, small hydrated particle size, and improvement of hypoxia

Active Publication Date: 2021-09-17
NANJING UNIV OF POSTS & TELECOMM
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  • Description
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Problems solved by technology

[0005] This patent has invented a nano-photodynamic reagent that can be excited by near-infrared light and self-supply oxygen. It not only needs to improve the delivery of photosensitizers, but also solve the problem of light penetration depth and hypoxia in tumor tissues. The specific technology The scheme is as follows

Method used

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  • A nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen and its preparation and application
  • A nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen and its preparation and application
  • A nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen and its preparation and application

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Embodiment 1

[0037] The preparation method of the nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen provided by this embodiment is as follows:

[0038] S1. Slowly add 1mL oleic acid dropwise to 50mL potassium permanganate aqueous solution with a concentration of 2mg / mL at room temperature, make the mixture form a stable emulsion at a stirring speed of 600r / min, and continue to react for 24h; then centrifuge, wash with water and ethanol Ultrasonic dispersion to remove impurities, ready for use;

[0039] S2, take by weighing 1 mg of the product obtained in step S1 and disperse it in ultrapure water to obtain a nano-manganese dioxide solution with a concentration of 1 mg / mL; then dissolve the near-infrared photosensitizer IR780 of 1 mg in absolute ethanol, according to a volume ratio of 3: 2. Add it into the nano-manganese dioxide solution, sonicate at intervals of 10min, 6 times, stir for 8h, and centrifuge; then add water and ethanol to ultrasonicall...

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Abstract

The invention discloses a nano-photodynamic reagent capable of near-infrared light excitation and self-supplying oxygen. The nano-photodynamic reagent is composed of sea urchin-like manganese dioxide nanometer material, near-infrared dye and bovine serum albumin. The sea urchin-like manganese dioxide nanomaterial is prepared by using oleic acid as a soft template, potassium permanganate as a manganese source, and reacting at room temperature for a certain period of time. Then, the near-infrared photosensitizer IR780 and bovine serum albumin BSA were modified onto the surface of nano-manganese dioxide by electrostatic adsorption and hydrogen bonding to obtain a nano-photodynamic reagent with near-infrared light excitation and self-oxygenation functions, and its performance was tested. The functionalized nanoparticles described in the material have the advantages of being excitable by near-infrared light, responding to the tumor microenvironment, and improving tumor hypoxia, and have the technical advantage of simple preparation process, so they have important application prospects in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of nano-reagents, in particular to a nano-photodynamic reagent capable of near-infrared light excitation and self-supplying oxygen, as well as its preparation and application. Background technique [0002] Half a century ago, cancer was still an unfamiliar word to Chinese people. But in just fifty years, cancer has become one of the diseases most closely related to people, and its morbidity and mortality are among the top three. According to the "2015 China Cancer Statistics" led by Academician Hejie, director of the National Cancer Center, it is estimated that there will be 4.292 million new cancer cases in China in 2015, and the number of cancer deaths may exceed 2.814 million. [0003] Therefore, the prevention and treatment of cancer has become a difficult but important thing. Traditional treatment methods include surgery, radiation, chemical drugs, etc., but these methods will cause greater trauma to the patien...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/64A61K47/69A61P35/00
CPCA61K41/0052A61K41/0057A61K47/643A61K47/6923A61P35/00A61K2300/00
Inventor 刘湘梅田康张京徽赵强黄维刘淑娟
Owner NANJING UNIV OF POSTS & TELECOMM
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