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A kind of near-infrared light control on-demand oxygen supply nano-diagnostic agent and preparation method and application thereof

A technology of near-infrared light and infrared photosensitizer, which is applied in the preparation technology of nanomaterials and the field of special materials, can solve the problem of not being able to provide oxygen at a fixed point and time for tumor tissues, and achieve enhanced photodynamic therapy, good biocompatibility, and easy preparation Effect

Active Publication Date: 2022-07-22
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent can alleviate the hypoxic environment of tumor tissue, it cannot provide oxygen to tumor tissue at fixed time

Method used

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  • A kind of near-infrared light control on-demand oxygen supply nano-diagnostic agent and preparation method and application thereof
  • A kind of near-infrared light control on-demand oxygen supply nano-diagnostic agent and preparation method and application thereof
  • A kind of near-infrared light control on-demand oxygen supply nano-diagnostic agent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A near-infrared light-controlled on-demand oxygen supply nano-diagnostic agent provided by the present embodiment, the preparation method thereof is as follows:

[0041] S1: Dissolve 25 mg of near-infrared photosensitizer IR780 and 10 mg of Rhodamine B in 75 mL of absolute ethanol at room temperature, and stir for 30 min;

[0042] S2: 80uL of tetraethoxysilane was slowly added dropwise to the solution prepared in step S1 at room temperature, and stirred for 30min;

[0043] S3: 4 mL of ammonia water was rapidly added to step S2 at room temperature, reacted at a stirring speed of 600 r / min for 24 h, and the product was centrifuged and washed 3 times with ultrapure water and dried;

[0044]S4: Dissolve 4 mg of the product obtained in step S3 in 2 mL of ultrapure water at room temperature, dissolve 20 mg of polyvinylpyrrolidone with a relative number average molecular weight of 40K in 2 mL of ultrapure water, and add the nanoparticle solution dropwise into the ultrapure aq...

Embodiment 2

[0047] The difference between Example 2 and Example 1 is that S5: the concentration of hydrogen peroxide is 2.9 mol / L; the remaining steps are the same as those in Example 1 to prepare a nanodiagnostic agent.

Embodiment 3

[0049] The difference between Example 3 and Example 1 is that S5: the concentration of hydrogen peroxide is 5.9 mol / L; the remaining steps are the same as those in Example 1, and the nano-diagnostic agent is prepared.

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Abstract

The invention discloses a near-infrared light-controlled on-demand oxygen supply nano-diagnostic agent and a preparation method and application thereof. The nano-diagnostic reagent adopts the near-infrared photosensitizer IR780 and rhodamine B to simultaneously load to obtain a silica nanocomposite material, and then modifies and supports hydrogen peroxide by polyvinylpyrrolidone to obtain good biocompatibility, small and uniform particle size, and good stability. , and the nano-therapeutic agent that can supply oxygen on demand, and test its performance. The nanodiagnostic agent is beneficial to the self-oxygenated photodynamic therapy of cancer cells and tumors. It has the technical advantages of simple preparation process, low cost and wide application range, so it has important applications in the fields of biomedicine, chemical industry, functional materials and so on. prospect.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation technology and special material technology, and in particular relates to a near-infrared light-controlled on-demand oxygen supply nano-diagnostic agent and a preparation method and application thereof. Background technique [0002] Half a century ago, cancer was an unfamiliar word to the Chinese. But in just 50 years, cancer has become one of the diseases most closely related to people, and its morbidity and mortality are among the "top three". The "2015 China Cancer Statistics" led by Academician He Jie, director of the National Cancer Center, predicts that there will be 4.292 million new cancer cases and more than 2.814 million cancer deaths in China in 2015. [0003] Hypoxia is a hallmark feature of solid tumors, but this is contrary to the conditions for efficient PDT, so the hypoxic environment of the tumor is a major factor limiting solid tumors. In addition, the consumption of oxyg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/04A61K47/32A61K49/00A61P35/00
CPCA61K41/0057A61K41/0052A61K9/5115A61K9/5138A61K49/0041A61K49/0093A61P35/00A61K2300/00
Inventor 刘湘梅田康吴昊明周严莉赵强黄维刘淑娟
Owner NANJING UNIV OF POSTS & TELECOMM
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