Synthesis method and application of nano composite material

A nanocomposite material and synthesis method technology, applied in the field of materials science and biomedicine, can solve the problems of poor photodynamic therapy effect and oxygen consumption, achieve good photothermal/photodynamic effect, reduce dosage, and facilitate promotion Effect

Active Publication Date: 2017-10-20
HUBEI UNIV
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At the same time, photodynamic therapy requires a large amount of oxygen to participate, but malignant tumors are vigorous and consume a lot of oxygen, making the effect of photodynamic therapy not very good

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Synthesis method and application of nano composite material
  • Synthesis method and application of nano composite material
  • Synthesis method and application of nano composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) The preparation of NMOFs nanoparticles, the specific steps are as follows:

[0041] Prepare ferric ion solution, weigh 2.7mg FeCl 3 ·6H 2 O was dissolved in 10mL of N,N-dimethylformamide (1mmol / L), and set aside; to prepare a porphyrin solution, weigh 7.90mg of meso-tetrakis(4-carboxyphenyl)porphine (TCPP, relative molecular Mass=790g / mol) was dissolved in 10mL of N,N-dimethylformamide (1mmol / L) and set aside.

[0042] Take 1mL FeCl prepared above 3 ·6H 2 O, TCPP solution in a 25mL three-necked flask, add 10mL of N,N-dimethylformamide, and add 0.4mL of acetic acid, stir at room temperature for 2h; then, raise the temperature of the system to 80°C, react for 24h, and wait for the reaction temperature After cooling to room temperature, wash with N,N-dimethylformamide solvent, ethanol, and deionized water for several times, and dry the product in a vacuum oven at 60°C for 24 hours to prepare NMOFs nanoparticles.

[0043] (2) preparation of protein / sulfonamide comp...

Embodiment 2

[0050] (1) The preparation of NMOFs nanoparticles, the specific steps are as follows:

[0051] Prepare ferric ion solution, weigh 4.04mg Fe(NO 3 ) 3 9H 2 O was dissolved in 10mL of N,N-dimethylacetamide (1mmol / L), and set aside; to prepare a porphyrin solution, weigh 7.90mg of meso-tetrakis(4-carboxyphenyl)porphine (TCPP, relative molecular Mass=790g / mol) was dissolved in 10mL of N,N-dimethylacetamide (1mmol / L), and set aside.

[0052] Take 1mL Fe(NO 3 ) 3 9H 2 O, TCPP solution in a 25mL three-necked flask, add 10mL of N,N-dimethylacetamide, and add 0.4mL of acetic acid, stir at room temperature for 2h; then, raise the temperature of the system to 100°C, react for 20h, and wait for the reaction temperature After cooling to room temperature, wash with N,N-dimethylacetamide, ethanol, and deionized water by centrifugation several times, and dry the product in a vacuum oven at 60°C for 24 hours to prepare NMOFs nanoparticles.

[0053] (2) preparation of protein / sulfonamide ...

Embodiment 3

[0060] (1) The preparation of NMOFs nanoparticles, the specific steps are as follows:

[0061] Prepare ferric ion solution, weigh 5.62mg Fe 2 (SO 4 ) 3 9H 2 O was dissolved in 10mL of methanol (1mmol / L), and set aside; to prepare a porphyrin solution, weigh 7.90mg of meso-tetrakis(4-carboxyphenyl)porphine (TCPP, relative molecular mass=790g / mol) and dissolve it in 10mL of methanol (1mmol / L), set aside.

[0062] Take 1mL FeCl prepared above 3 ·6H 2 O, TCPP solution in a 25mL three-necked flask, add 10mL of organic solvent, and add 0.4mL of acetic acid, stir at room temperature for 2h; then, raise the temperature of the system to 80°C, react for 20h, wait for the reaction temperature to cool to room temperature, use Methanol, ethanol, and deionized water were centrifuged and washed several times, and the product was dried in a vacuum oven at 60°C for 24 hours to prepare NMOFs nanoparticles.

[0063] (2) preparation of protein / sulfonamide complex, concrete steps are as fol...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a synthesis method and application of a nano composite material. The composite material is prepared by a simple and easily operable two-step method. Specifically, ferric ions are adopted as the center, porphyrin is taken as the organic ligand for self-assembly to prepare organic metal framework structure nanoparticles, and a protein / sulfanilamide compound is employed to modify the prepared organic metal framework structure nanoparticles through a chemical bond effect, thus obtaining the protein / sulfanilamide-organic metal framework structure nano composite material. The nano composite material has photothermal / photodynamic effect simultaneously, has obvious killing effectiveness on tumor cells, and has enormous potential application value in cancer and tumor treatment.

Description

technical field [0001] The invention relates to the technical fields of material science and biomedicine, in particular to a synthesis method and application of a nanocomposite material. Background technique [0002] At present, malignant tumors are a serious threat to human health and are one of the diseases with a high mortality rate. Clinically, the means of tumor treatment are mainly surgery, drug therapy and radiotherapy. However, problems such as infection, drug resistance of the body, and lethality to normal tissues limit its development. Phototherapy is a new discovery in tumor treatment, including phototherapy and photodynamic therapy. It uses specific wavelengths of light to transfer energy to sensitizers to increase the temperature of the surrounding environment or generate a large amount of oxygen in a single ground state, ablation Tumor cells make it die quickly. Phototherapy can selectively treat tumor sites, avoid damage to normal tissues, kill almost all t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K41/0076
Inventor 徐祖顺朱伟任精华阳哲张力王晶
Owner HUBEI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap