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Nanometer diagnosis and treatment agent under control of near infrared light and capable of supplying oxygen as needed, and preparation method and application of agent

A near-infrared light and oxygen supply technology, which is applied in the field of nanomaterial preparation technology and special materials, can solve the problem of inability to provide oxygen at a fixed point and time to tumor tissue, and achieve enhanced photodynamic therapy, good biocompatibility, and easy preparation. Effect

Active Publication Date: 2020-08-25
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this patent can alleviate the hypoxic environment of tumor tissue, it cannot provide oxygen to tumor tissue at fixed time

Method used

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  • Nanometer diagnosis and treatment agent under control of near infrared light and capable of supplying oxygen as needed, and preparation method and application of agent
  • Nanometer diagnosis and treatment agent under control of near infrared light and capable of supplying oxygen as needed, and preparation method and application of agent
  • Nanometer diagnosis and treatment agent under control of near infrared light and capable of supplying oxygen as needed, and preparation method and application of agent

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A near-infrared light-controlled on-demand oxygen supply nano-diagnosis and treatment agent provided in this embodiment, its preparation method is as follows:

[0041] S1: Dissolve 25 mg of near-infrared photosensitizer IR780 and 10 mg of rhodamine B in 75 mL of absolute ethanol at room temperature, and stir for 30 min;

[0042] S2: slowly drop 80uL of tetraethoxysilane into the solution prepared in step S1 at room temperature, and stir for 30min;

[0043] S3: quickly add 4 mL of ammonia water to step S2 at room temperature, react at a stirring speed of 600 r / min for 24 h, and centrifuge wash the product 3 times with ultrapure water and dry it;

[0044]S4: Dissolve 4 mg of the product obtained in step S3 in 2 mL of ultrapure water at room temperature, dissolve 20 mg of polyvinylpyrrolidone with a relative number average molecular weight of 40K in 2 mL of ultrapure water, and add the nanoparticle solution dropwise into the ultrapure aqueous solution of polyvinylpyrrolid...

Embodiment 2

[0047] The difference between Example 2 and Example 1 is that S5: the concentration of hydrogen peroxide is 2.9 mol / L; the rest of the steps are the same as in Example 1 to prepare the nano-medicine.

Embodiment 3

[0049] The difference between Example 3 and Example 1 is that S5: the concentration of hydrogen peroxide is 5.9 mol / L; the rest of the steps are the same as in Example 1 to prepare the nano-medicine.

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Abstract

The invention discloses a nanometer diagnosis and treatment agent under control of near infrared light and capable of supplying oxygen as needed, and a preparation method and application of the agent.The nanometer diagnosis and treatment reagent is prepared through the steps of performing loading with near infrared photosensitizer IR780 and rhodamine B to obtain a silicon dioxide nanometer composite material, and then modifying and loading the nanometer composite material with hydrogen peroxide and polyvinylpyrrolidone to obtain the nanometer diagnosis and treatment agent which is good in biocompatibility, small and uniform in particle diameter, good in stability and capable of supplying oxygen as needed. The properties of the nanometer diagnosis and treatment agent are tested. The nanometer diagnosis and treatment agent facilitates automatic oxygen supply photodynamic treatment of cancer cells and tumors, and has the technical advantages of being simple in preparation technology, lowin cost, wide in application scope and the like, so that the nanometer diagnosis and treatment agent has important application prospects in the fields of biopharmaceuticals, chemical industry, functional materials and the like.

Description

technical field [0001] The invention belongs to the field of nanomaterial preparation technology and special material technology, and specifically relates to a near-infrared light-controlled on-demand oxygen supply nanometer diagnostic agent and its preparation method and application. Background technique [0002] Half a century ago, cancer was still an unfamiliar word to Chinese people. But in just fifty years, cancer has become one of the diseases most closely related to people, and its morbidity and mortality are among the top three. According to the "2015 China Cancer Statistics" led by Academician Hejie, director of the National Cancer Center, it is estimated that there will be 4.292 million new cancer cases in China in 2015, and the number of cancer deaths may exceed 2.814 million. [0003] Hypoxia is a hallmark feature of solid tumors, but this is contrary to the conditions for efficient PDT, so the hypoxic environment of tumors is a major factor limiting solid tumor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/04A61K47/32A61K49/00A61P35/00
CPCA61K41/0057A61K41/0052A61K9/5115A61K9/5138A61K49/0041A61K49/0093A61P35/00A61K2300/00
Inventor 刘湘梅田康吴昊明周严莉赵强黄维刘淑娟
Owner NANJING UNIV OF POSTS & TELECOMM
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