Nanometer photodynamic reagent with near-infrared light excitation and oxygen self-supply functions, and preparation and application of nanometer photodynamic reagent
A technology of near-infrared light and self-supplying oxygen, which is applied in photodynamic therapy, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as penetration depth and hypoxia in tumor tissues , to achieve the effects of small hydration particle size, good biocompatibility and rich raw materials
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[0037] The preparation method of the nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen provided by this embodiment is as follows:
[0038] S1. Slowly add 1mL oleic acid dropwise to 50mL potassium permanganate aqueous solution with a concentration of 2mg / mL at room temperature, make the mixture form a stable emulsion at a stirring speed of 600r / min, and continue to react for 24h; then centrifuge, wash with water and ethanol Ultrasonic dispersion to remove impurities, ready for use;
[0039] S2, take by weighing 1 mg of the product obtained in step S1 and disperse it in ultrapure water to obtain a nano-manganese dioxide solution with a concentration of 1 mg / mL; then dissolve the near-infrared photosensitizer IR780 of 1 mg in absolute ethanol, according to a volume ratio of 3: 2. Add it into the nano-manganese dioxide solution, sonicate at intervals of 10min, 6 times, stir for 8h, and centrifuge; then add water and ethanol to ultrasonicall...
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