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Nanometer photodynamic reagent with near-infrared light excitation and oxygen self-supply functions, and preparation and application of nanometer photodynamic reagent

A technology of near-infrared light and self-supplying oxygen, which is applied in photodynamic therapy, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as penetration depth and hypoxia in tumor tissues , to achieve the effects of small hydration particle size, good biocompatibility and rich raw materials

Active Publication Date: 2019-03-01
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] This patent has invented a nano-photodynamic reagent that can be excited by near-infrared light and self-supply oxygen. It not only needs to improve the delivery of photosensitizers, but also solve the problem of light penetration depth and hypoxia in tumor tissues. The specific technology The scheme is as follows

Method used

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  • Nanometer photodynamic reagent with near-infrared light excitation and oxygen self-supply functions, and preparation and application of nanometer photodynamic reagent
  • Nanometer photodynamic reagent with near-infrared light excitation and oxygen self-supply functions, and preparation and application of nanometer photodynamic reagent
  • Nanometer photodynamic reagent with near-infrared light excitation and oxygen self-supply functions, and preparation and application of nanometer photodynamic reagent

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Embodiment 1

[0037] The preparation method of the nano-photodynamic reagent capable of near-infrared light excitation and self-supply oxygen provided by this embodiment is as follows:

[0038] S1. Slowly add 1mL oleic acid dropwise to 50mL potassium permanganate aqueous solution with a concentration of 2mg / mL at room temperature, make the mixture form a stable emulsion at a stirring speed of 600r / min, and continue to react for 24h; then centrifuge, wash with water and ethanol Ultrasonic dispersion to remove impurities, ready for use;

[0039] S2, take by weighing 1 mg of the product obtained in step S1 and disperse it in ultrapure water to obtain a nano-manganese dioxide solution with a concentration of 1 mg / mL; then dissolve the near-infrared photosensitizer IR780 of 1 mg in absolute ethanol, according to a volume ratio of 3: 2. Add it into the nano-manganese dioxide solution, sonicate at intervals of 10min, 6 times, stir for 8h, and centrifuge; then add water and ethanol to ultrasonicall...

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Abstract

The invention discloses a nanometer photodynamic reagent with near-infrared light excitation and oxygen self-supply functions. The nanometer photodynamic reagent comprises urchin-like manganese dioxide nanometer materials, near-infrared dye and bovine serum albumin. Oleic acid is used as a soft template, potassium permanganate is used as a manganese source, and reaction is carried out at the roomtemperature for a certain time to prepare the urchin-like manganese dioxide nanometer materials. Near-infrared photosensitizers IR780 and the bovine serum albumin BSA are modified on the surfaces of nanometer manganese dioxide under electrostatic adsorption and hydrogen bond effects to obtain the nanometer photodynamic reagent with the near-infrared light excitation and oxygen self-supply functions, and the performance of the nanometer photodynamic reagent is tested. The nanometer photodynamic reagent has the technical advantages that functionalized nanometer particles of the nanometer photodynamic reagent which is a material can be excited by near-infrared light and are responsive to tumor micro-environments, and tumor hypoxia can be improved by the functionalized nanometer particles; processes for preparing the nanometer photodynamic reagent are simple, and accordingly the nanometer photodynamic reagent has an important application prospect in the field of biomedicine.

Description

technical field [0001] The invention belongs to the field of nano-reagents, in particular to a nano-photodynamic reagent capable of near-infrared light excitation and self-supplying oxygen, as well as its preparation and application. Background technique [0002] Half a century ago, cancer was still an unfamiliar word to Chinese people. But in just fifty years, cancer has become one of the diseases most closely related to people, and its morbidity and mortality are among the top three. According to the "2015 China Cancer Statistics" led by Academician Hejie, director of the National Cancer Center, it is estimated that there will be 4.292 million new cancer cases in China in 2015, and the number of cancer deaths may exceed 2.814 million. [0003] Therefore, the prevention and treatment of cancer has become a difficult but important thing. Traditional treatment methods include surgery, radiation, chemical drugs, etc., but these methods will cause greater trauma to the patien...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/64A61K47/69A61P35/00
CPCA61K41/0052A61K41/0057A61K47/643A61K47/6923A61P35/00A61K2300/00
Inventor 刘湘梅田康张京徽赵强黄维刘淑娟
Owner NANJING UNIV OF POSTS & TELECOMM
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