Bone restoration support frame for bone tuberculosis treatment and preparation method thereof

Abstract

The invention relates to a bone restoration support frame for bone tuberculosis treatment and a preparation method thereof, and belongs to the technical field of biomedicine engineering. The bone restoration support frame contains strontium-doped nanometer hydroxyapatite, gelatin and sodium alginate medicine carrying microspheres. The bone restoration support frame has an antituberculous medicineslow release system of a three-dimensional porous support frame structure. Compared with implementing bodies with other forms, the support frame has the advantages that the cell and blood vessel growth is facilitated; the new bone regeneration is promoted; the antituberculous medicine is effectively released for a long time in the local part of the tuberculosis disease; the good local environmentis provided for bone defect healing. The medicine carrying anti-bone tuberculosis restoration support frame has good mechanical property and biocompatibility; the antituberculous medicine can be continuously released; good bone induction capability and bone conduction capability are realized; the regeneration of the bone tissue defect position can be induced.

Description

technical field [0001] The invention relates to a bone repair bracket for bone tuberculosis treatment and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] The incidence of bone and joint tuberculosis accounts for about 3 to 5% of the total incidence of tuberculosis, and is the highest incidence of extrapulmonary tuberculosis. 90% of them invade the load-bearing parts such as vertebral body, knee joint and hip joint. In the infection focus, Mycobacterium tuberculosis causes hypersensitivity reactions through pathogenic components such as lipids, proteins, and polysaccharides, leading to local bone destruction and sequestrum formation. In the late stage of the disease, as the bacterial infection spreads, the bone mass is severely lost, leading to chronic tuberculous osteomyelitis, pathological fractures and paralysis, and the disability rate is extremely high. [0003] At present, the mainstream method fo...

AI Technical Summary

Problems solved by technology

However, this treatment method mainly has two problems: (1) the postoperative systemic drug administration efficiency is too low and the time is too long, generally at least 6 to 9 months of multi-drug combination chemotherapy

Because the bone tissue infected with Mycobacterium tuberculosis is at the end of the blood circulation and there are a large number of bacterial thrombi, the blood supply is poor, and the efficiency of systemic administration is low. Long-term medication not only accelerates the bacterial resistance, but also increases the toxic side effects on the patient's liver and kidneys.

(2) Debridement of the lesion can easily lead to local bone defects, which need to be repaired and reconstructed. However, the characteristics of Mycobacterium tuberculosis that are difficult to eradicate lead to an inflammatory environment in the local area of ​​the lesion, which is extremely unfavorable for the formation of new bone

[0004] The existing drug-loaded anti-tuberculosis bone repair scaffolds generally have the disadvantages of single drug loading, fast drug release, unsatisfactory mechanical properties of the scaffold, and poor degradation performance and osteogenesis ability.

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