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Biological material with anti-thrombosis function and preparation method thereof

A biomaterial and antithrombotic technology, applied in drug delivery, pharmaceutical formulation, surgery, etc.

Active Publication Date: 2019-03-08
中国医科大学
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, a series of problems such as the orderly and compact arrangement of phospholipids on the surface of materials and the stability of simulated biological membranes are still far from being resolved.

Method used

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  • Biological material with anti-thrombosis function and preparation method thereof
  • Biological material with anti-thrombosis function and preparation method thereof
  • Biological material with anti-thrombosis function and preparation method thereof

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Embodiment Construction

[0026] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments, but the following embodiments do not limit the scope of rights of the present invention.

[0027] Example.

[0028] 30 mg N 3 -PEG 6-NHS (azido PEG active lipid) was dissolved in 4ml THF (tetrahydrofuran), added 0.5 ml DIEA (N,N-disopropyl-amine, N,N-diisopropylethylamine) and diluted to 8ml with water, and the Put the solid material on the surface into the solution, shake gently at room temperature, take out the solid material after 8 hours of reaction, and wash with THF (3 times, 5 minutes each time) and water (3 times, 5 minutes each time) respectively. Rinse and dry with nitrogen gas to obtain a solid material with surface azide.

[0029] Distearoylphosphatidylethanolamine-PEG2000 (DSPE-PEG2000-NH 2 , 94.4 mg, 0.034mmol) was dissolved in 3 mL chloroform under the protection of argon, and then 20 mg (0.029 mmol) DBCO-PEG 4 -NHS was dissolved in...

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Abstract

The invention belongs to the field of medical materials, in particular to a biological material for simulating anti-thrombosis of endothelial cells and a preparation method thereof. According to the biological functional material with the anti-thrombosis function, a complete and stable liposome is fixed on the surface of a solid material through a chemical method, a liposome covering layer is stably arranged the surface of a specific material in an ordered mode, the selection specificity of Click Chemistry is utilized, furthermore, the surface of the liposome is modified by using thrombomodulin so as to realize the functionalization of the liposome, and therefore the anti-thrombus function of the endothelial cells can be simulated. The material with the surface modified with bioactive molecules has the advantage that the incompatibility caused on the surface due to the fact that the material of interventional equipment makes contact with blood in an interventional therapy (such as theintervention of coronary heart diseases, support) method and the thrombosis caused by the stress reaction of the immune system can be greatly reduced.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a biomaterial simulating endothelial cells to resist rethrombosis and a preparation method thereof. Background technique [0002] Biofunctional materials with nanostructures have shown attractive application prospects in many fields, making them one of the most active research fields in chemistry and materials in the 21st century, especially in the field of biomedicine. At present, for the treatment of thrombotic vascular diseases, restoring the normal flow of blood through interventional techniques such as stents and catheters is the main treatment. However, the surface incompatibility caused by the material of the interventional device in contact with blood and the vascular stenosis or occlusion caused by the re-thrombosis caused by the stress response of the immune system often limit the long-term application of this type of interventional device. Among the diseas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/16A61L31/14
CPCA61L31/10A61L31/14A61L31/16A61L2300/236A61L2300/252A61L2300/42A61L2300/626A61L2420/02
Inventor 马勇
Owner 中国医科大学
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