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Traditional Chinese medicine peptide for treating chicken influenza and preparation method of traditional Chinese medicine peptide

A chicken flu and traditional Chinese medicine technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, peptide/protein ingredients, etc., can solve the problems of slow effect, long treatment period, meat and egg drug residues, etc., and achieves narrow distribution, No toxic side effects, small molecular weight effect

Inactive Publication Date: 2019-03-15
河北肽都生物科技集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Aiming at the problem that the existing traditional Chinese medicine is slow to take effect and the treatment cycle is long in the treatment of chicken flu, and there are drug residues in the treatment of meat and eggs in western medicine, the present invention provides a traditional Chinese medicine peptide for treating chicken flu

Method used

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  • Traditional Chinese medicine peptide for treating chicken influenza and preparation method of traditional Chinese medicine peptide
  • Traditional Chinese medicine peptide for treating chicken influenza and preparation method of traditional Chinese medicine peptide

Examples

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Embodiment 1

[0037] This embodiment provides a traditional Chinese medicine peptide for treating chicken flu, which is obtained by enzymatic hydrolysis of raw materials with the following proportions by weight: Radix Radix: 9 parts, Forsythia: 8 parts, Astragalus: 8 parts, and Glycyrrhizae: 7 parts.

[0038] The preparation method of the above-mentioned traditional Chinese medicine peptide for the treatment of chicken flu comprises the following steps:

[0039] Step a, respectively select 900g Radix Radix, 800g Forsythia, 800g Astragalus and 700g Licorice, add 22.4L of purified water, stir evenly, and decoct at 90°C for 8 hours;

[0040] Step b. Cool the decoction liquid obtained in step a to 56°C, add 32g of Aspergillus niger amylase and 32g of Aspergillus oryzae neutral protease for enzymolysis, after the end of enzymolysis, raise the temperature to 90°C and keep for 10min to inactivate the enzyme, and obtain the enzymolysis solution, wherein the enzymolysis conditions are: the enzymolys...

Embodiment 2

[0044]This embodiment provides a traditional Chinese medicine peptide for treating chicken flu, which is obtained by enzymatic hydrolysis of raw materials with the following proportions by weight: Radix Radix: 18 parts, Forsythia: 15 parts, Astragalus: 15 parts, and Glycyrrhizae: 12 parts.

[0045] The preparation method of the above-mentioned traditional Chinese medicine peptide for the treatment of chicken flu comprises the following steps:

[0046] Step a, select Radix Radix 18Kg, Forsythia 15Kg, Radix Astragali 15Kg and Licorice 12Kg respectively, add 450L of purified water, stir evenly, and decoct at 93°C for 7.5 hours;

[0047] Step b. Cool the decoction liquid obtained in step a to 57°C, add 750g of Aspergillus niger amylase and 750g of Aspergillus oryzae neutral protease for enzymolysis, after the end of enzymolysis, raise the temperature to 92°C and keep for 12 minutes to inactivate the enzyme to obtain enzymolysis solution, wherein the enzymolysis conditions are: the...

Embodiment 3

[0051] This example provides a traditional Chinese medicine peptide for treating chicken flu, which is obtained by enzymatic hydrolysis of raw materials with the following proportions by weight: Radix Radix: 27 parts, Forsythia: 22.5 parts, Astragalus: 21 parts, and Glycyrrhizae: 17 parts.

[0052] The preparation method of the above-mentioned traditional Chinese medicine peptide for the treatment of chicken flu comprises the following steps:

[0053] Step a, select Radix Radix 27Kg, Forsythia 22.5Kg, Radix Astragali 21Kg and Licorice 17Kg respectively, add 700L of purified water, stir evenly, and decoct at 95°C for 7 hours;

[0054] Step b. Cool the decoction solution obtained in step a to 58°C, add 1312.5g of Aspergillus niger amylase and 1312.5g of Aspergillus oryzae neutral protease for enzymolysis, and after the enzymolysis, heat up to 95°C and keep for 15 minutes to inactivate the enzyme to obtain Enzymolysis solution, wherein the enzymolysis conditions are: the enzymoly...

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Abstract

The invention relates to the technical field of poultry medicines and particularly discloses traditional Chinese medicine peptide for treating chicken influenza and a preparation method of the traditional Chinese medicine peptide. The traditional Chinese medicine peptide is prepared from raw materials in parts by weight as follows: 9-27 parts of radix isatidis, 7.5-22.5 parts of fructus forsythiae, 7.5-22.5 parts of radix astragali and 6-18 parts of radix glycyrrhizae through enzymolysis. The preparation method comprises the steps as follows: mixing the raw materials of the traditional Chinesemedicine peptide for treating the chicken influenza, and adding purified water for decoction; cooling a decoction liquid to 56-58 DEG C, adding amylase and neutral protease for enzymolysis at 55-58 DEG C for 3-4 h, and performing enzyme deactivation after enzymolysis to obtain an enzymatic hydrolysate; performing separation, purification and drying on the enzymatic hydrolysate to obtain the traditional Chinese medicine peptide for treating the chicken influenza. All components of the traditional Chinese medicine peptide are matched, and decoction and enzymolysis extraction manners are combined, so that excellent acting effects are realized.

Description

technical field [0001] The invention relates to the technical field of poultry medicine, in particular to a traditional Chinese medicine peptide for treating chicken flu and a preparation method thereof. Background technique [0002] Chicken influenza, also known as European chicken plague and true chicken plague, is an acute infectious disease caused by chicken influenza virus. There are many types of clinical manifestations, some are respiratory infections with low lethality, and some are acute hemorrhagic infections with high lethality, with short incubation period and fast transmission speed, which can lead to the onset of whole group infection within a few days. At present, there are two main treatment methods for chicken flu. One is to prevent chicken flu by adopting vaccine immunization, but there is a risk of not being able to obtain immune protection when the inoculated vaccine is different from the prevailing subtype; the other is western medicine treatment. , Com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K36/634A61P31/16
CPCA61K36/195A61K36/315A61K36/481A61K36/484A61K36/634A61K38/011A61K2236/19A61K2236/331A61P31/16A61K2300/00
Inventor 张晓东杨广杨子丰
Owner 河北肽都生物科技集团有限公司
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