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Modified taurine and preparation method therefor

A taurine modification technology, applied in organic chemistry methods, chemical instruments and methods, preparation of organic compounds, etc., can solve problems such as taurine modification or composition difficulties

Inactive Publication Date: 2019-03-15
边钟贤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, it is very difficult to make taurine into therapeutically active modified substances or compositions for various diseases. Therefore, taurine is usually only used as a raw material for amino acid food at present.

Method used

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  • Modified taurine and preparation method therefor
  • Modified taurine and preparation method therefor
  • Modified taurine and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: Preparation of modified taurine

[0066] 1-1: Preparation of a composition containing modified taurine

[0067] Taurine (8.6 g) was added to 30 ml of pure water, and heated in a microwave oven for about 60 seconds to dissolve, and then 60 ml of alcohol (ethanol (alcohol was used hereinafter), methanol, , propanol or butanol) or acetone, thereby preparing the composition (see figure 1 ), the composition is a mixture comprising a white semi-solid substance.

[0068] 1-2: Preparation of modified taurine crystals

[0069] (1) Add taurine (1.72g) to 6ml of pure water, or (2) Add taurine (4.3g) to 15ml of pure water, or (3) Add taurine (8.6g) to 28ml of pure water in the water. Heat in microwave oven for 20-60 seconds to dissolve the added taurine, then immediately add 12ml of ethanol (corresponding to the above (1)) or 30ml of ethanol (corresponding to the above (2)) at room temperature while stirring the taurine solution with a stirrer )) or 60 ml of et...

Embodiment 2

[0072] Embodiment 2: preparation is used for preventing or treating the pharmaceutical composition of metabolic disease

[0073] 2-1: Preparation 1, modified taurine + pentose sugar composition

[0074]A predetermined amount (2.5g or 3.5g) of pentose (xylose or arabinose) was added to 32ml of pure water, and heated in a microwave oven for 30 seconds to completely dissolve. Separately, taurine (8.6 g) was added to 28 ml of pure water and heated in a microwave oven for 60 seconds to dissolve, and then immediately 60 ml of ethanol was added while stirring the taurine solution with a stirring bar, thereby preparing a white semi-solid substance. mixture. Next, the above-prepared aqueous pentose sugar solution was added to the mixture, which was then heated in a microwave oven for about 5 minutes until the alcohol was completely removed, thereby preparing a composition. (The composition ratio of each composition is shown in Table 1).

[0075] 2-2-1: Preparation 2, modified taur...

Embodiment 3

[0110] Embodiment 3: the property analysis of modified taurine

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Abstract

The present invention relates to modified taurine and a method for preparing the same and, more particularly, to modified taurine different from conventional taurine in a distance between an intramolecular carbon (C) atom and a sulfur (S) atom adjacent thereto, and a preparation method therefor. Superior in terms of prophylactic and therapeutic effect on metabolic diseases, the modified taurine ofthe present invention is expected to find a wide spectrum of applications in the medical field.

Description

technical field [0001] The present invention relates to a modified taurine and a preparation method thereof, more particularly, to a modified taurine in which the distance between atoms of carbon (C) and sulfur (S) attached thereto is different from that of conventional taurine. Taurine and its preparation method. Background technique [0002] Obesity is a disease caused by excess body fat accumulation due to an imbalance between the body's energy intake and expenditure. Obesity can cause physical diseases such as cardiovascular disease, diabetes, hypertension, hyperlipidemia, gallstone disease, etc., and can also affect mental health, so countermeasures against obesity are urgently needed (Kopelman P G. Obesity as a medical problem (Obesity asmedical problem) . Nature 404:635-643, 2000). In particular, although Orientals have a lower body mass index than Europeans, Orientals have severe abdominal obesity and thus are more prone to complications caused by arterial-related ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/14C07C303/42A61K31/18
CPCA61K31/185A61K31/7004A61P3/04A61P3/10C07B2200/13C07C309/14A61K31/18C07C303/42
Inventor 边钟贤
Owner 边钟贤