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Identification and quantification of conjugated peptides in antibody drug conjugates by mass spectrometry

A technology of antibody drugs and conjugates, applied in the field of streamlined and complete workflow, can solve the problem of lack of ADC peptide workflow, and achieve the effect of eliminating complex steps, high selectivity and sensitivity

Pending Publication Date: 2019-03-15
WATERS TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to date, the biopharmaceutical industry still lacks a complete workflow capable of effectively identifying and quantifying ADC peptides

Method used

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  • Identification and quantification of conjugated peptides in antibody drug conjugates by mass spectrometry
  • Identification and quantification of conjugated peptides in antibody drug conjugates by mass spectrometry
  • Identification and quantification of conjugated peptides in antibody drug conjugates by mass spectrometry

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Embodiment Construction

[0029] Reference will now be made in detail to certain embodiments of the invention, examples of which are illustrated in the accompanying drawings. While the invention will be described in conjunction with the enumerated embodiments, it will be understood that they are not intended to limit the invention to those embodiments. On the contrary, the invention is intended to cover all alternatives, modifications and equivalents, which may be included within the scope of the present invention as defined by the claims. One skilled in the art will recognize many methods and materials similar or equivalent to those described herein, which could be used in the practice of the present invention. The present invention is in no way limited to the methods and materials described.

[0030] definition

[0031] Unless otherwise stated, the following terms and phrases used herein are intended to have the following meanings:

[0032] As used herein, an "antibody drug conjugate" or "ADC" i...

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Abstract

The present disclosure relates to a streamlined, complete workflow for the qualitative and the quantitative analysis of conjugated peptides from antibody-drug conjugate (ADC) compounds.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of and priority to U.S. Provisional Application No. 62 / 302,333, filed March 2, 2016, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to a streamlined complete workflow for the qualitative and quantitative analysis of conjugated peptides from antibody drug conjugate (ADC) compounds. Background technique [0004] Antibody drug conjugate (ADC) compounds represent a growing class of immunoconjugate therapies. ADC compounds are complex molecules composed of monoclonal antibodies linked to biologically active high on cytotoxic drugs. Conjugation of potent drugs to monoclonal antibodies enables targeted delivery of toxic payloads to the tumor surface while minimizing systemic toxic effects on healthy tissues, thereby improving the therapeutic window of this type of cancer treatment modality. [0005] Incomplete conjugatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/72G01N33/68
CPCH01J49/004G01N33/6848G01N30/7233G01N30/72G01N2030/027
Inventor 陈柳西W.陈S.库贝奇
Owner WATERS TECH CORP