Gelatin microsphere embolic agent with uniform particle size and preparation method thereof

Abstract

The invention discloses a gelatin microsphere embolic agent with a uniform particle size and a preparation method thereof. The method comprises the following steps: dissolving gelatin or a mixture ofthe gelatin and medicines in water at 40-70 DEG C, adding a 0.1-1% photoinitiator, performing uniform stirring and filtration to obtain a 15-50% gelatin solution mixture, shearing the gelatin solutionmixture and oil phase liquid paraffin containing span80 with a mass ratio of 1-20% in a microchannel so as to form gelatin microspheres, wherein the water/oil volume ratio is 1/1 to 1/10, and the gelatin microspheres formed by shearing wind around a radiation source device at a certain rate in the microchannel, the distance between the radiation source and the gelatin microspheres is 3-30 cm, andthe radiation time is 1-30 min, collecting the microspheres into a container after the radiation, and then performing washing and dehydration to obtain the microsphere embolic agent. The gelatin microspheres prepared by the method of the invention have good roundness, uniform particle size and certain elasticity and expansibility, and the particle size of the microspheres is distributed in any narrow range of 50-1000 micrometers.

Description

technical field [0001] The invention relates to the technical field of interventional medical materials, in particular to a gelatin microsphere embolic agent for embolization therapy and the application of a preparation method thereof. Background technique [0002] As an emerging medicine, minimally invasive endovascular interventional therapy technology has been gradually promoted in China in recent years, and its therapeutic effect has been generally recognized. The general process is that under the guidance of medical imaging equipment, interventional medical devices are selectively delivered to many important organs and parts of the human body through naturally existing vascular channels, such as: heart, liver, brain, kidney, digestive system and reproductive system , is an important technology and method for diagnosis and treatment, and has the advantages of no need for surgery, less trauma, and relatively low medical expenses. [0003] The treatment and effect of inte...

AI Technical Summary

Problems solved by technology

At present, gelatin sponge particle embolic agent or shredded gelatin sponge is mainly used clinically in China, and there is no gelatin microsphere embolic agent on the market.

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