Unlock instant, AI-driven research and patent intelligence for your innovation.

Calibration method

A technology of calibration points and calibrators, applied in the fields of instruments, material inspection products, biological testing, etc., can solve the problems of time and cost increase, requiring different calibration procedures, frequent and other problems

Active Publication Date: 2022-05-24
F HOFFMANN LA ROCHE & CO AG
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Effective throughput and availability as well as the cost of running IVD analytes can be impacted by the fact that significant time may have to be dedicated to performing and repeating calibration procedures
This applies even more to those in vitro diagnostic analyzers that are configured to process different samples and test for different analytes in a random sequence and according to the type of sample and / or according to the assay being used analytes to test different reagents, meaning that different sample / analyte / reagent combinations may require different calibration procedures and be on a more frequent basis
Additionally, the time and cost to perform a calibration procedure increases with the number of calibrator levels required for the same calibration procedure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calibration method
  • Calibration method
  • Calibration method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0070] Figure 1 Demonstrates a method of calibrating an in vitro diagnostic analyzer. The method comprises performing a multipoint calibration procedure 100, comprising measuring a plurality of calibrator levels 10, 11, 12, thereby obtaining a plurality of corresponding calibration points 1-n, calculating the result of the multipoint calibration program 100 20 and based on the calculated result 20 to determine whether the multipoint calibration program 100 is faulty or through 30. In the case of the multipoint calibration program 100 fault, the method comprises determining whether the 40 fault is related to one or more separate fault calibration points 1-n, and when affirming 50, only about the fault calibration point 1 triggers a repeat 60 measurement of the calibrator level 10 and with the newly obtained calibration point 1 only replaces the fault calibration point 1 after recalculating the result of the multipoint calibration program 100 20 '. Only for the fault calibration po...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A computer-implemented method of calibrating an in vitro diagnostic analyzer is disclosed. The method includes performing a multi-point calibration procedure comprising measuring a plurality of calibrator levels and thereby obtaining a plurality of corresponding calibration points. The method further includes calculating a result of the multi-point calibration procedure and determining whether the multi-point calibration procedure fails or passes based on the calculated result. In the event of a failure of the multi-point calibration procedure, the method includes determining whether the failure is associated with one or more individual failed calibration points, and in the affirmative, triggering repeated measurements of the calibrator level with respect to the failed calibration point only and in use The result of the multi-point calibration procedure is recalculated after the newly obtained calibration point only replaces the faulty calibration point.

Description

Technical field [0001] The present disclosure relates to a computer-implemented method of calibrating an in vitro diagnostic analyzer. Background [0002] In medicine, a physician's diagnosis and patient treatment often rely on the measurement of analyte concentrations or other parameters of a patient's sample. This measurement is typically performed by an in vitro diagnostic analyzer that can be configured to analyze a specific type of sample and use a variety of detection techniques to detect a specific type of analyte. Since the patient's life may depend on the precision and reliability of this measurement, it is important that the instrument works correctly. [0003] In vitro diagnostic analyzers are generally required to implement a set of quality control (QC) procedures to check that they are working correctly. [0004] One of these procedures is to perform calibration. In most cases, calibration is performed using a standard solution at a known concentration. In this way, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48
CPCG01N33/48G01N35/00693G01N35/00623G01N2035/00653G01N2035/00702
Inventor M·克林贡夫
Owner F HOFFMANN LA ROCHE & CO AG