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Omega 3 fatty acids and choline as neuroprotectant in patients with no dementia

A fatty acid and choline technology, applied in the field of compositions for cognitive aging, to achieve the effects of alleviating cognitive aging, reducing brain atrophy, and stimulating neuronal plasticity and activity

Pending Publication Date: 2019-04-26
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Several short-term studies also failed to show the effect of the combination of B6, B12, and folic acid on improving cognitive function

Method used

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  • Omega 3 fatty acids and choline as neuroprotectant in patients with no dementia
  • Omega 3 fatty acids and choline as neuroprotectant in patients with no dementia

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Experimental program
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Embodiment approach

[0047] In one aspect of the disclosure, the composition comprises a combination of omega-3 fatty acids and choline; and preferably, the composition comprises the combination in an amount effective to reduce cognitive aging and / or improve cognitive performance in non-demented individuals. In another aspect, a method for reducing cognitive aging and / or improving cognitive ability in a non-demented individual comprises administering (eg, orally) an effective amount of a composition to the individual.

[0048] In one embodiment, the composition is administered to the individual at a daily dose providing 0.01 to 10.0 times the recommended daily allowance (RDA) of choline, eg, 0.15 to 6.0 times the RDA for choline. In this regard, the RDA for choline is 550 mg / day, so the composition can be administered at a daily dose providing 5.5 mg / day to 5,500 mg / day choline (e.g., 85 mg / day to 3,500 mg / day choline) . But the present disclosure is not limited to a specific daily dosage of chol...

Embodiment 1

[0074] The following non-limiting examples are experimental examples demonstrating that embodiments of the compositions comprising omega-3 fatty acids and choline provided by the present disclosure can reduce cognitive aging in non-demented individuals.

[0075] Specifically, this experimental study compared the effects of selected components alone and in combination on synapse formation in human iPSC-derived neuronal cultures + astrocytes. Cells were grown for two weeks (neurons + astrocytes), and then the medium was replaced with a custom medium. Treatment for 48 hours (n=8) followed by immunocytochemistry + high content imaging + image analysis. figure 1 A table showing the processing is provided. Such as figure 2 As shown, combining DHA+EPA and choline (T3) at high concentrations significantly increased the number of synapses.

Embodiment 2

[0077] The following non-limiting examples are illustrative of compositions of embodiments provided by the present disclosure for reducing cognitive aging in non-demented individuals.

[0078] Element

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PUM

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Abstract

A method of attenuating, treating or preventing cognitive aging in an individual who does not have dementia includes administering to the individual a therapeutically effective amount of a compositioncontaining an omega-3 fatty acid and choline. The method can achieve a benefit that is one or more of decreasing brain atrophy, increasing or maintaining number of synapses, increasing amyloid-beta phagocytosis, or decreasing or maintaining neuroinflammation in the non-demented individual. The method can prevent dementia in an individual at risk thereof, for example an elderly human. The composition can be administered to the individual in a daily dose that provides 5.5 mg / day to 5,500 mg / day of the choline, for example 85 mg / day to 3,500 mg / day of the choline.

Description

Background technique [0001] The present disclosure generally relates to compositions and methods for reducing cognitive aging in individuals without dementia. More specifically, the present disclosure relates to reducing cognitive aging by administering a composition comprising a combination of omega-3 fatty acids and choline. [0002] Population aging has always been a notable demographic event. The growth rate of the middle-aged and elderly population has exceeded the growth rate of the total population due to the increase in life expectancy, and the proportion of the middle-aged and elderly people relative to the rest of the population has greatly increased due to the decline in the birth rate. For example, in 1950, at least one in twelve people was at least 60 years old, and in 2000 at least one in ten people was 60 or older. By the end of 2050, the number of people in the world who are 60 or over is projected to be one in five people. [0003] Older or aging individual...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/202A61P25/28A61K31/14
CPCA61K31/14A61K31/198A61K31/202A61K31/4415A61K31/519A61K31/714A61K31/197A61K31/341A61K31/355A61K31/4188A61K31/455A61K31/51A61K31/525A61K31/59A61K31/675A61K33/04A61P25/28A61P43/00A61K2300/00A61K31/17A61K31/375A61K31/4406A61K33/00
Inventor C·里克尔J·于德里-拉贝J·A·J·施密特C·波沙Y·B·希尔伯
Owner SOC DES PROD NESTLE SA
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