Brain health food or brain health beverage, and method for administering same

A food and beverage technology, applied in the field of brain-enhancing food or drink, can solve the problems of brain atrophy that have not been mentioned, and achieve the effect of inhibiting the reduction of brain volume and promoting health

Inactive Publication Date: 2018-10-26
朴启彰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The above-mentioned patent documents 1-2 are reports on the recovery of brain functions for Alzheimer's disease, and the influence of non-demented healthy people on brain atrophy due to habitual intake of alcohol is not mentioned at all.
[0013] In addition, according to the records in Non-Patent Documents 3-5, in order to prevent brain atrophy caused by MCI (mild cognitive impairment) in the elderly over 70 years old, folic acid, vitamin B6, and vitamin B12 were provided, but non-dementia Habitual drinkers who are not MCI, that is, able-bodied people are targeted

Method used

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  • Brain health food or brain health beverage, and method for administering same
  • Brain health food or brain health beverage, and method for administering same
  • Brain health food or brain health beverage, and method for administering same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] (Embodiment 1. Evaluation of the influence of intake of brain-invigorating food on brain atrophy)

[0065] The brain-enhancing food of the present invention was ingested by non-dementia patients (able persons), and the preventive effect on brain atrophy caused by alcohol intake was evaluated.

[0066]

[0067] The subjects were 96 able-bodied persons (48 males and 48 females), and the effect of ingesting brain-invigorating food was detected through a randomized double-blind test. The test subjects were able-bodied people (average 48.4 years old) aged 30-60 years (average 48.4 years old), non-smokers and not taking nutritional supplements, and their health status including liver function was good.

[0068] The test subjects were divided into two groups, group A took placebo, and group B took a medicine containing 0.8 mg of folic acid, 20 mg of vitamin B6, and 0.5 mg of vitamin B12 every day. The subjects checked the following items at the 0th month, the 3rd month, and...

Embodiment 2

[0082](Example 2. Evaluation of the effect of intake of brain-invigorating food on brain atrophy, and the effect of MTHFR)

[0083] Based on the data obtained in Example 1, the genotypes (CC type: wild type, CT type: heterotype, TT type: homotype) of the SNP of MTHFR, the rate-limiting enzyme that metabolizes homocysteine, were used to conduct research again (see Figure 4A -C). Firstly, the subjects were divided into 3 groups (CC type, CT type, TT type) according to the 3 different genotypes among the MTHFR SNPs. Next, the same analysis as in Example 1 (comparison of group AB among numerical distributions of groups I, II, and III) was performed for each test group. As a result, the numerical distribution deviation of group I to group III in CT type (abnormal type) is very significant among AB groups (Mann-Whitney U test: p Figure 4B ). On the other hand, although the deviation of the numerical distribution in the CC type (wild type) has a similar tendency to that of the CT ...

Embodiment 3

[0084] (Example 3. The groups that provide brain-invigorating food to slow down the brain atrophy caused by drinking are regarded as the same (Δ condition))

[0085] The method of using the brain volume detection obtained by MRI in the above-mentioned embodiments 1 and 2 is to map the brain of the subject to a standard brain with a predetermined size, and after obtaining the probability distribution of the brain volume, obtain each brain volume by inverse mapping. The VBM (voxelbased morphometry) method of brain volume, however, the annual change of the brain volume of healthy people is as low as 1-2ml, so a more accurate detection method is needed.

[0086] Therefore, in this embodiment, different TBM (tensor based morphometry) methods are used for analysis, which do not penetrate the standard brain, but directly compare the brain volume of the subject's brain at two time points. That is, for the effect of preventing brain atrophy caused by alcohol intake, the whole brain vol...

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Abstract

A brain health food / brain health beverage for preventing / alleviating brain atrophy due to alcohol intake is developed. The brain health food or brain health beverage containing, as active ingredients,folic acid, vitamin B6, and vitamin B12, for preventing a decrease in the brain capacity of regular drinkers who are not suffering from dementia, i.e., healthy people, is characterized by containing,as active ingredients, 0.4-0.8 mg of folic acid, 10-20 mg of vitamin B6, and 0.25-0.5 mg of vitamin B12.

Description

technical field [0001] The present invention relates to a brain-enhancing food or drink, and its application method, in particular, to a food or drink containing folic acid, vitamin B6 and vitamin B12 in its ingredients, and its application method. Background technique [0002] According to the calculation of the research department of the Ministry of Health, Labor and Welfare (2008), the social loss caused by drinking alcohol in a year is more than 4,149.3 billion yen. These include 1.2226 billion yen in medical expenses for liver disease, stroke, cancer and other diseases and injuries, 3.947 billion yen in employment losses such as labor losses and productivity declines caused by diseases and deaths, and expenses for automobile accidents, crimes, 28.3 billion yen in social insurance. Coupled with problems such as family disintegration and its impact on children that are difficult to convert into actual amounts, alcohol-related problems cause very huge social losses, and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L2/52A61K31/4415A61K31/519A61K31/714A61P25/28
CPCA61K31/4415A61K31/519A61K31/714A23V2002/00A61P25/00A61P25/28A61P43/00A61K2300/00A23V2200/322A23V2250/7052A23V2250/7056A23V2250/706A23L2/52A23L33/15A23L33/40A61P25/32A61K9/0056A61K9/0095
Inventor 朴启彰
Owner 朴启彰
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