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Traf 6 inhibitors

A C1-C6, C6-C10 technology, applied in the field of TRAF 6 inhibitors, can solve problems such as the reduction of NF-κB activation

Active Publication Date: 2019-05-03
HELMHOLTZ ZENT MUNCHEN DEUTES FORSCHUNGSZENT FUR GESUNDHEIT & UMWELT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In particular, these compounds are believed to counteract the catalytic activity of TRAF6, resulting in reduced NF-κB activation

Method used

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Embodiment Construction

[0283] Although the present invention is described in further detail below, it is to be understood that this invention is not limited to the particular methodology, protocols and reagents described herein as these may vary. It is also to be understood that the terminology used herein is for describing particular embodiments only, and that it is not intended to limit the scope of the invention, which will be limited only by the appended claims. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0284] Elements of the invention are described in more detail below. These elements are recited as specific embodiments, however, it should be understood that they may be combined in any manner and in any number to produce additional embodiments. The various examples and preferred embodiments described in the specification should not be construed as limiting the invention but as mer...

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Abstract

The invention relates to compounds which are suitable for the treatment of cancer, an immune disease, Parkinson's disease, Cardiac Hypertrophy or type-2 diabetes and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds.

Description

Background technique [0001] The TRAF protein family includes seven members, namely TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7, which have great homology in their domain structures (Xie, P., TRAF molecules in cell signaling and in human diseases .J Mol Signal,2013.8(1):p.7 and Zotti,T.,P.Vito, and R.Stilo,The seventh ring:exploring TRAF7functions.J Cell Physiol,2012.227(3):p.1280-4) . Research over the past few years has revealed a large family of signaling receptors that comprise the TRAF protein for signaling to turn on. These pathways include Toll-like receptors (TLRs), the IL-1 receptor family, T-cell receptors, IL-17 receptors, TNF receptors, and the like. TRAF-dependent signaling pathways primarily promote the activation of (i) transcription factors NF-κB and (ii) mitogen-activated protein kinases (MAPKs), thereby contributing to the control of various cellular processes such as survival, proliferation, , differentiation, activation, cytokine production and aut...

Claims

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Application Information

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IPC IPC(8): C07D487/04A61P35/00A61P25/16A61P17/06A61P3/10A61P9/00A61P37/00
CPCA61P25/16A61P17/06A61P9/00A61P35/00A61P37/00A61P3/10A61K31/5025C07D487/04
Inventor K·哈迪安J·K·布伦克O·普勒滕贝格G·朱尔金斯
Owner HELMHOLTZ ZENT MUNCHEN DEUTES FORSCHUNGSZENT FUR GESUNDHEIT & UMWELT