Interfering RNA that suppresses Rac1 expression and its application in increasing chemosensitivity of breast cancer
A breast cancer, high-sensitivity technology, applied in the directions of organic active ingredients, inorganic active ingredients, and non-active ingredients medical preparations, etc., can solve the problems of single treatment mode and uncontrollable drug release, and achieve high enrichment, Improved chemosensitivity and longer cycle time
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[0037] This embodiment provides a chemotherapeutic drug for breast cancer, including nanocarriers responsive to the acidic pH of endosomes, the nanocarriers are loaded with siRNA and chemotherapeutic drugs, and the siRNA can knock down the expression of the drug resistance gene Rac1 of cancer cells.
[0038] Wherein, the siRNA is an interfering RNA that inhibits the expression of Rac1, and its gene sequence can be 5'-AGACGGAGCTGTAGGTAAA-3' (siRac1-1), as shown in SEQ NO.1, and its gene sequence can also be 5'-CCTTTGTACGCTTTGCTCA-3 '(siRac1-2), as shown in SEQ NO.2.
[0039] In this embodiment, what the nanocarrier adopts is polyethylene glycol-b-poly(2-(diisopropylamino)ethyl methacrylate) (PEG-b-PDPA), and its response pH value is The matrix environment of the cell endosome has a pH value range, that is to say, the response pH value of the nanocarrier is 6.0-6.5. In practical applications, nanocarriers are not limited to PEG-b-PDPA, as long as the response pH is within the pH ...
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