74results about How to "No obvious damage" patented technology

The invention discloses a novel multi-ribbed composite wall structure system with three anti-vibration defense lines, which includes a first anti-vibration defense line point contact type X-shaped filling building block, a second anti-vibration defense line reinforced concrete multi-ribbed frame grid unit, a third anti-vibration defense line reinforced concrete invisible outer frame and acast-in-situ reinforced concrete floor, wherein the point contact type X-shaped filling building block and the concrete frame grid are contacted at four corner parts, flexible material is filled between the point contact type X-shaped filling building block and the concrete frame grid, 10-50mm slit is arranged between the side surface of the multi-ribbed frame grid unit and an outer frame column, and the multi-ribbed frame grid unit and top surface and bottom surface of an outer frame beam are anchored in the frame beam through rib column longitudinal steel bars to realize rigid connection. The structure system has three specific anti-vibration energy-dissipating defense lines, each defense line sequentially performs dominant defense effect under earthquake with different grades, thereby reaching the purpose of dissipating earthquake energy and reducing earthquake reaction by stages; and load transmission path is clear, mechanical model is simple and visual, thereby being convenient for realizing elaborate design of the multi-ribbed composite wall structure.

The invention relates to the technical field of nano-biomaterials, in particular to a multi-layer electrospun membrane and the use thereof. The multi-layer electrospun membrane includes an inner layer material, an intermediate layer material and an outer layer material. The multi-layer electrospun membrane is used as a dura mater substitute material, and has significantly improved performances as compared with a collagen matrix through comparison tests on mechanical properties, porosity, water absorption and water repellency.

The invention mainly relates to activity of a drug glycyrrhizin with anti-PEDV (porcine epidemic diarrhea virus) activity in resistance to host cells infected with a PEDV HLJBY strain, and belongs to the field of antivirus applications. The drug glycyrrhizin is an extract of traditional Chinese medicine liquorice and can effectively inhibit endocytosis and duplication of PEDV, thereby effectively inhibiting PEDV infection. Vero cells verify that glycyrrhizin performs the anti-virus effect mainly by inhibiting virus endocytosis and duplication.

The invention provides a tumor microenvironment stimulation degradable amphiphilic block HPMA (hydroxypropyl methacrylate) polymer delivery system which is a conjugate of HPMA polymer, cathepsin B substrate GFLG, and small-molecular drug gemcitabine; the nano delivery system formed by self-assembly of the amphiphilic block conjugate has enzyme responsive degrading capacity and drug release capacity, gemcitabine is delivered by being conjugated to the amphiphilic block HPMA polymer skeleton, the molecular weight of the system is relatively high, the system may effectively collect at a tumor part, has good biocompatibility and antitumor effect, and by introducing near-infrared fluorescent probe Cy5.5, self-tracing capacity is imparted to the system.

The invention discloses equipment for treating vitligo by utilizing turnable lattice dual wavelength laser. A superpulse CO2 laser device and an ultraviolet laser device are integrated in the equipment. Under the control of a control system, the superpulse CO2 laser and the ultraviolet laser can be outputted according to pulse width, peak value power and pulse power, which are required by therapy, are respectively outputted through a beam switcher according to requirements, and are outputted to a two-dimensional optical scanning polariscope system through a coupler and a guiding arm. Then, the laser beams are outputted by the optical scanning system in a lattice distribution form, and are irradiated on focuses of skin surfaces of patients after being focused by a focusing mirror, thus, the equipment for treating vitligo by utilizing turnable lattice dual wavelength laser is manufactured. The device is mainly used for treating vitligo, particularly is suitable for treating acral vitligo, and is also suitable for treating neurodermatitis (hypertrophic type), chronic eczema, psoriasis, trichophytia, alopecia areata, scleriasis, lymphoma cutis and the like.

The invention provides a preparation process for a highly oriented graphite composite material. The process is characterized by adopting the steps of: 1) preparing a graphite cast sheet by tape casting method: firstly adding a binder and a plasticizer into a solvent and mixing them evenly, then adding ceramic powder, mixing the mixture evenly to form a casting material, then performing tape casting, and carrying out drying and demoulding at room temperature to obtain a 50-150micrometer thick graphite cast sheet; 2) slicing the graphite cast sheet according to the mould size respectively; 3) superimposing the graphite cast sheet slices and placing them into a graphite grinding tool, and carrying out pre-press forming; 4) putting the pre-press formed green body and the graphite grinding tool into vacuum to conduct vacuum degreasing; and 5) carrying out hot pressing sintering in argon atmosphere, thus obtaining the highly oriented graphite composite material. The process provided by the invention is simple and is safe to operate, the prepared graphite composite material has high orientation, the bending strength and fracture toughness of loading in the vertical level direction are enhanced by 20% and 5% respectively than those of loading in the horizontal level direction. At the same time, the oxidation resistance is increased obviously.

The invention discloses immunosorbent for blood purification and a preparation method thereof. The immunosorbent for the blood purification comprises a polymer carrier serving as an adsorbent matrix and a ligand fixed on the surface of the carrier by means of chemical crosslinking, wherein the ligand at least comprises a tryptophan ligand and a phenylalanine ligand, and the molar ratio of the tryptophan ligand to the phenylalanine ligand is 1:0.1-1:1. The immunosorbent for the blood purification has good clearing effects on immunoglobulin G (IgG) virulence factors, immune complexes and panel reactive antibodies (PRA).

The invention belongs to the technical field of pharmaceutical preparations, and relates to a penetration enhancer for nasal delivery and application thereof. The invention relates to a penetration enhancer for promoting nasal absorption. Specifically, the penetration enhancer is a low-temperature molten salt for promoting nasal cavity absorption, and the low-temperature molten salt is an ionic liquid or eutectic solvent formed by reacting an organic acid with at least one organic base and / or a salt thereof. The penetration enhancer can dissolve active ingredients, and the active ingredients comprise indissolvable drugs and biomacromolecule drugs, for example, the penetration enhancer can significantly promote nasal absorption of insulin to achieve an ideal hypoglycemic effect. The penetration enhancer can be used alone or in combination with other carriers to promote transnasal mucosa transport of drug molecules, and has no obvious damage effect on the nasal mucosa.

The invention relates to a scale remover of a flue gas reheater in a flue gas desulfurization system. The scale remover comprises the components of, by weight, 30-45% of concentrated hydrochloric acid, 8-9% of urotropine, 4-6% of aniline, 2-3% of sodium fluoride, 1% of an anionic surfactant, and balance of water. The scale remover provided by the invention has good removing effect against GGH hard scales, and has the characteristics such as low environment pollution and high adaptability.

The invention discloses a super-long carbon nanotube macro fiber and a preparation method thereof and application thereof in electric arc, and relates to the technical field of nano materials. The high strength carbon nanotube macro fiber is prepared from carbon nanotube macro tubular continuous body. The carbon nanotube macro fiber under the DC voltage of 20-30V in a closed shell touches a metal electrode to produce a strong electric arc, and the generated electric arc can instantly melt metal electrode tin, aluminum or copper. The carbon nanotube macro fiber is simple and easy in technique, not only can be applied to the field of traditional metal smelting, welding and heat treatment, and application in the strong light source is also more obvious. The carbon nanotube macro fiber has advantages of easily available raw materials, low cost, no pollution to the environment; the product is easy to handle, efficiency is high, equipment is simple, semi continuous operation can be achieved, and the carbon nanotube macro fiber is suitable for mass production.

The invention discloses a structure of lactarius deliciosus polysaccharide and an application thereof; the lactarius deliciosus polysaccharide is heteropolysaccharide composed of two monosaccharides which are alpha-L-mannose and alpha-D-xylose with a ratio of 3:1; the lactarius deliciosus polysaccharide has an average molecular weight of 1.1*10<4> D, has a (1-6) alpha-L-mannose skeleton; a -3)-alpha-D-xylose side chain is connected with 2-O; a certain amount of lactarius deliciosus polysaccharide can significantly inhibit the growth of transplanted tumor S180. Groups with intraperitoneal injection of 20 mg / Kg.d, 40 mg / Kg.d, and 80 mg / Kg.d (L1, L2, L3 group) respectively have a tumor inhibition rate of 44.358%, 52.326%, and 68.422%; a positive control group with a concentration of 20 mg / Kg has a mannatide (M) tumor inhibition rate of 57.727%; no obvious damage, and no toxic or side effect are caused to mouse visceral organs; and the immunity is significantly improved.

The invention discloses a laser cutting method and device for a light filter. The laser cutting device comprises an ultrafast laser device, a light beam shaping module, a focusing objective lens, a visual detection device and a moving platform, wherein the visual detection device is located at the upper portion of the focusing objective lens, the moving platform is located at the lower portion ofthe focusing objective lens to be used for bearing the light filter, the focusing objective lens is an imaging objective lens of the visual detection device, the ultrafast laser device emits an ultrashort pulse laser beam into the light beam shaping module, the ultrashort pulse laser beam is shaped into a linear non-diffracting light beam of evenly-distributed energy to be emitted into the focusing objective lens, and the linear non-diffracting light beam is focused by the focusing objective lens to form a high-energy-density non-diffracting light beam for cutting the light filter. According to all elements cut and obtained by the laser cutting method and device, the sections and the upper and lower surfaces are all formed regularly, the straightness is good, surface film layers have no obvious damage, and the thickness and position of modified layers formed in the cutting process can be selected according to the thickness of a base plate or the actual requirements to meet the machining requirements for different specifications.

The invention provides a traditional Chinese medicine composition for preventing swine fever and a preparation method thereof. The traditional Chinese medicine composition is composed of 5-25 parts of scutellaria baicalensis, 3-17 parts of radix bupleuri, 3-17 parts of dandelion, 5-25 parts of liquorice, 8-26 parts of fructus forsythia and 3-15 parts of ephedra. The traditional Chinese medicine composition has an extremely obvious effect for preventing swine fever, is safe without toxic or side effect and meets the production requirements of green and pollution-free pork.

The invention provides a method for preparing a natural tubular small intestine acellular matrix membrane and belongs to the technical field of medical biological materials. The method comprises the following steps: cleaning small intestines cut from animals; adding the cleaned small intestines into a closed container, rapidly freezing in liquid nitrogen at the temperature of 80 DEG C below zero,taking out within half an hour, unfreezing, sleeving on an annular tubular scaffold, destroying the serosa by scissors, cutting off the serosa of the small intestines, scraping the destroyed serosa ofthe small intestines by organic glass, turning over the small intestines, scraping the mucous layer, submucosa and muscular layer of the small intestines, and removing the basal cells of the small intestines, thereby obtaining the single-layer tubular small intestine acellular matrix membrane; and performing freeze-dried seal and sterilizing preservation on the obtained single-layer and multilayer tubular small intestine acellular matrix membranes, thereby obtaining the natural tubular small intestine acellular matrix membranes of different thicknesses. The preparation method disclosed by theinvention is simple, and the prepared small intestine acellular matrix membrane is natural tubular.

The invention aims at providing a preparation method of delicious beef offal containing head, hoof and tripe, belonging to the field of comprehensive utilization of beef byproducts, and solving the problem that the taste and mouthfeel are seriously influenced by the seasonings mainly staying on raw material surfaces. The preparation method comprises the following steps: raw material selection, burning and cleaning, ultrasonic-assisted primary boiling, adding of water and accessories, ultrasonic-assisted tasty boiling and packaging. In the invention, an ultrasonic-assisted boiling method is adopted; and through the ultrasonic-assisted primary boiling process, the head and hoof are boned and separated more easily, and the peculiar smell such as blood smell is removed; and meanwhile, relatively high crispness of the tripe is realized. The preparation method provided by the invention mainly has the following beneficial effects: (1) the head and hoof slices have more complete appearance without obvious damage; (2) the tripe is crisper; and (3) the head, hoof and tripe are tastier, and the taste permeation is better.

The invention discloses a preparation process of a cleaning fluid for liquid crystal display screen thinning. The preparation process comprises the following steps: S1, selecting raw materials; S2, preparing an auxiliary emulsifier; S3, preparing a cleaning aid liquid; and S4, preparing a waterborne cleaning fluid. The preparation process of the cleaning fluid for liquid crystal display screen thinning is characterized in that a cationic surfactant as a cationic emulsifier and an auxiliary emulsifier which is prepared as a nonionic emulsifier by adding a short-carbon-chain isomeric fatty alcohol polyether to a compound of isomeric alcohol ethoxylate 1309L and linear alcohol ethoxylate AEO-9 are mixed with water, and then added with additives and the cleaning aid to obtain the waterborne cleaning fluid; and the waterborne cleaning fluid has excellent cleaning and emulsifying effects on residual liquid crystals on a liquid crystal display screen with a good cleaning decontamination rate,is non-corrosive to a liquid crystal display screen glass sealant, and has a good cleaning effect on residual glass scraps, finger marks, dust and other dirt on display screen glass.

The invention discloses a tackifying particle for tackifying a rail transit wheel-rail interface, and a preparation method thereof. The preparation method comprises the following steps: 1, adding silica powder into water to form a premixed liquid; 2, carrying out spray drying on the premixed solution obtained in step 1 to form a particle green body; and 3, sintering the particle green body obtained in step 2 to obtain the finished product particle. The tackifying particle prepared by the invention can effectively avoid the problems of wheel rail wear and damage aggravation caused by hard particles in the tackifying process while meeting the wheel rail tackifying requirement; and tests show that the wear rate of the wheel rail material in the tackifying process is reduced by 70% compared with the traditional sand particle tackifying process, and the wheel rail sample has a smooth surface and has no obvious damage such as particle indentation and the like.

The invention provides healthcare pills capable of assisting in reducing blood glucose. The pills comprise 15-18 parts of Radix Ginseng, 13-15 parts of Rhizoma Polygonati Odorati extract, 9-12 parts of Radix Astragali extract, 29-31 parts of Rhizoma Dioscoreae extract, 12-14 parts of Rhizoma Polygonati extract, 2-5 parts of Poria extract and 20-22 parts of maltodextrin. The healthcare pills capable of assisting in reducing the blood glucose have the advantages that the healthcare pills are a healthcare product researched and developed according to modern technologies based on traditional medicine and further exploration of previous scientific and technological achievements; human feeding trials and animal functional tests prove that the healthcare pills prepared from the Radix Ginseng, Rhizoma Polygonati Odorati, Radix Astragali, Rhizoma Dioscoreae, Rhizoma Polygonati, Poria and the maltodextrin according to modern technologies are capable of assisting in reducing the blood glucose.

The invention relates to a yttrium oxide-tungsten continuous gradient material and a preparation method thereof and application to high-temperature alloy smelting crucible manufacturing. The gradient material comprises a tungsten layer with a thickness of 10, a yttrium oxide layer with a thickness of 11, and a transition layer with a thickness of 12 and with a tungsten-enriched surface and a yttrium oxide-enriched surface; 10 and 11 are independently not lower than 0; 12 is higher than 0; and the volume fraction of yttrium oxide in the transition layer from a position z of the tungsten-enriched surface is CY2O3=(z-10 / 1)p, and the volume fraction of tungsten is CW=1-CY2O3, wherein 1=10+12, p=0.1, z is not higher than 1 and not lower than 10. The method preferentially adopts a free precipitation mode to combine with a cold press molding and sintering process to form the transition layer. The invention further provides the application of the gradient material to manufacturing of high-temperature alloy smelting crucibles. The gradient material is excellent in thermal shock resistance and erosion resistance, and can be widely applied to the field of high-temperature alloy smelting. The method is simple in process, lower in energy consumption, environment-friendly and broad in industrial application prospect.

The invention discloses a method for preparing a back point contact structure of a crystalline silicon solar cell, which specifically comprises the following steps of: carrying out screen printing on a prepared suede structure and the back surface of a P-N junction washed sample for preparing a photoetching glue point array; preparing a SiO2 passive film by using a vacuum film coating or PECVD (Plasma Enhanced Chemical Vapor Deposition) method and removing the photoetching glue point array by an alkali solution to form a back point contact structure. After an aluminum electrode is prepared on a substrate with the structure, the collection and the guide of current carriers are realized in the point array position. The preparation method has the advantages of changing a method for forming a back point contact structure array pattern by laser ablation into a screen printing method, having low cost, being suitable for mass production, and also having no obvious injury on the silicon substrate. Meanwhile, a SiO2 film with a thickness of 155 nm in the back surface position can form highest reflection in a near-infrared diffusion state with the interface position of the aluminum back electrode, thereby improving the conversion efficiency of the crystalline silicon cell.

The invention discloses an environmental-protection biological desulfurization process including the following steps: (1) putting coal in a stirring reaction kettle, adding water and a thiobacillus ferrooxidans liquid, mixing the mixture evenly, and carrying out a reaction for 7-10 h at room temperature; (2) at the temperature of 25-30 DEG C, carrying out a stirring reaction for 2-5 h; (3) adding a sulfosphaerellus thermoacidophilum liquid and a rhodococcus rhodochrous liquid in the reaction kettle, and at the temperature of 35-45 DEG C, carrying out a stirring reaction for 3-6 h; and (4) washing the coal in the reaction kettle with water while stirring, filtering, and then drying to obtain desulfurization coal. The biological desulfurization process has low requirements for equipment, has no damage to a coal structure, is short in desulfurization time and high in efficiency, is beneficial for protection of the ecological environment, and has a good market prospect.

The invention discloses an amino acid sequence specifically combined with mycobacterium tuberculosis or a derivative of the amino acid sequence. The amino acid sequence or the derivative of the aminoacid sequence contains an amino acid sequence shown as SEQ ID NO: 1. The invention also discloses a nucleotide sequence for encoding the amino acid and application of the amino acid sequence. The amino acid sequence disclosed by the invention can be specifically combined with mycobacteria and is used for diagnosing tuberculosis, the diagnosis sensitivity and specificity are improved, and a new method is provided for targeted diagnosis of tuberculosis.

The invention discloses a high-efficiency Golgi apparatus targeting compound and biological application thereof, and the compound has the following general formula structure, wherein R1 represents an electron withdrawing group selected from one or more of electron withdrawing groups, R2 represents a substituted / substituted electron donating group in which one or multiple sites of one or more benzene rings is / are substituted by H or R3, R3 represents C1-C12 alkyl, C1-C12 alkoxy or C1-C12 fluoroalkoxy, and when the the sites are substituted by a plurality of R3 , the substituent groups are the same or different. The compound based on aggregation-induced emission can effectively target Golgi apparatus, is used for tumor treatment or cell imaging, and is especially used for cell / tissue / living tumor treatment.

The invention discloses a biological desulfurization technology used for coal. The biological desulfurization technology comprises the following steps: 1) placing coal in a reaction vessel, adding water and a thiobacillus ferrooxidans solution, uniformly mixing the materials and reacting the materials for 5-10 hours at room temperature; 2) at temperature of 20-30 DEG C, stirring a reaction product and reacting the product for 2-5 hours; 3) adding a thiobacillus thiooxidans solution and a rhodococcus rhodochrousin solution in the reaction vessel, stirring the materials and reacting the materials for 6-8 hours at temperature of 30-40 DEG C; and 4) washing the coal in the reaction vessel while being stirred, and filtering the coal and drying the coal to obtain the desulfurated coal. The biological desulfurization technology has low requirement on equipment, has no damage on coal structure, has the advantages of short desulphurization time and high efficiency, is in favor of protection of ecological environment, and has good market prospect.

The invention belongs to the technical field of medicine development and particularly discloses pleurotus ostreatus polysaccharide selenoside III. The invention discloses an oyster mushroom polysaccharide selenoside III anticancer drug capable of effectively inhibiting gastric cancer, and discloses a preparation method of the oyster mushroom polysaccharide selenoside III anticancer drug. The oyster mushroom polysaccharide selenoside III anticancer drug can specifically kill gastric cancer cells, and can promote metabolism and proliferation of normal cells; a feasible scheme is provided for treating gastric cancer.

The invention relates to an yttrium oxide-tungsten gradient material, a preparation method thereof and an application of the material to manufacture of an alloy smelting crucible. The gradient material comprises an yttrium oxide layer and a plurality of transition layers, volume fractions of yttrium oxide and tungsten of the m transition layer are calculated according to the formula shown in the specification, CYm and CWm are volume fractions of the yttrium oxide and the tungsten of the m transition layer respectively, m is a natural number from 1 to (n-1), l refers to the overall thickness of the transition layers, n refers to the overall layer number of the yttrium oxide layer and the transition layers and is larger than or equal to 3, Hi refers to the thickness of the i layer, and Hm refers to the thickness of the m transition layer. The method includes the steps: weighing tungsten powder and yttrium oxide powder; laying corresponding layers with powder and forming and sintering the layers. The gradient material has high thermal conductivity and density, low thermal expansion coefficient and excellent corrosion resistance and thermal impact resistance, and can be widely used for high-temperature alloy smelting. The method is simple in process, easy to operate, low in energy consumption and environmentally friendly.

The invention relates to a EPCs lysate-sensitized DC vaccine derived from tumor microenvironment and a preparation method thereof. The prepared EPCs lysate-sensitized DC vaccine derived from tumor microenvironment is safe and effective, the body produces immunity against EPCs in the tumor microenvironment, the local EPCs is eliminated, and the tumor blood vessels can be destroyed. The DC vaccine can effectively kill EPCs, the tumor angiogenesis can be inhibited, the endothelial cells can be killed, and anti-tumor angiogenesis can be strengthened.

The invention relates to the field of biological medicines, in particular to interference RNA for inhibiting the Rac1 expression and an application thereof in increasing the chemosensitivity to breastcancer, and also discloses a breast cancer chemotherapeutic drug. The invention comprises the interference RNA for inhibiting the Rac1 expression and the chemotherapeutic drug, and a carrier of tumormicroenvironment response for transporting the interference RNA and the chemotherapeutic drug. According to the invention, an acid-sensitive nano-material is used as the carrier, can efficiently convey the siRNA and the chemotherapeutic drug into tumor cells, has a long circulation time in blood, and has high enrichment amount in tumors. Meanwhile, the nano-material encapsulates the siRNA and thechemotherapeutic pro-drug, can effectively silence the target gene and effectively inhibit the expression of drug-resistant genes, enhances the killing effect on tumor cells at the same time, obviously improves the tumor chemotherapy effect, has small toxic and side effects on normal tissue cells, and has no obvious damage to important organs such as heart and liver.

The invention discloses an artificially synthesized anticancer peptide and an acid responsive nanoparticle precursor thereof. The nanoparticle is formed by connecting an anti-cancer peptide and an amphiphilic monomethyl polyethylene glycol-polypropylene glycol polymer through an acid-responsive chemical bond. Tests prove that the anti-cancer peptide can kill tumor cells through membrane rupture activity, and has the advantages of excellent broad-spectrum anti-cancer activity and drug resistance. The nanoparticles are selectively sensitive to a tumor subacid environment, can completely release anti-cancer peptides, and play an active role of a targeted tumor cell line. And the polypeptide has the advantages of hemolysis resistance, high plasma stability, low in-vivo systemic toxicity, systemic drug delivery and the like. The nanoparticle has a remarkable inhibition effect on various tumor cells including triple negative breast cancer, and particularly has a relatively good clinical application potential on drug-resistant triple negative breast cancer.

The invention belongs to the technical field of medicine development, and particularly discloses pleurotus ostreatus polysaccharide selenoside-III. The invention discloses a pleurotus ostreatus polysaccharide selenoside-III anticancer drug with prostatic cancer resistance, and discloses a preparation method thereof. The pleurotus ostreatus polysaccharide selenoside-III anticancer drug can specifically kill prostatic cancer cells, and can promote metabolism and proliferation of normal cells. A feasible scheme is provided for treating the prostatic cancer.