Substance for lowering blood lipid and preparation method and application thereof

A fat-soluble substance, fat-soluble substance technology, applied in the directions of medical preparations, drug combinations, pharmaceutical formulations containing active ingredients, etc., can solve the problems of side effects, the effect of lowering blood lipids is not obvious, etc., and achieve good safety and good effect. Effect

Inactive Publication Date: 2019-05-24
徐爽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs such as statins, niacin, fibrates, etc., but they all have different degrees of side effects, and only have a good effect on one of hypercholesterolemia or hypertriglyceridemia; the main food Omega-3 fatty acid oils, but they have no obvious effect on lowering blood fat

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0024] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, heat to 120°C under 0.01atm vacuum to recover ethanol; then add 5kg of ether as unsaponifiable extractant for extraction, separate the upper layer extract, and heat to 85°C under 0.01atm vacuum to recover the extractant , to obtain 400g liquid substance, namely the present invention Hevea brasiliensis The unsaponifiable matter of the fat-soluble part of the seed.

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Embodiment 2

[0029] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then statically extruded at a pressure of 50MPa to obtain 12kg Hevea brasiliensis Fat-soluble substances of seeds.

[0030] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 440g remaining liquid matter and be exactly the present invention Hevea brasiliensis The unsaponifiable matter...

Embodiment 3

[0035] 100kg fresh Hevea brasiliensis Seeds are used as raw materials, and after drying and shelling, 40 kg of seed kernels are prepared. The seed kernel material is heated to 80-100°C, and then undergoes dynamic screw extrusion. The screw extrusion time is about 45 seconds, and the fat-soluble substance of 15kg seeds is extruded.

[0036] 10kg Hevea brasiliensis The fat-soluble matter of seeds is used as a raw material, and 10 kg of potassium hydroxide-ethanol solution is added to carry out saponification reaction, and the mass percent concentration of potassium hydroxide in ethanol is 22%. After the saponification reaction is completed, under 0.005atm vacuum condition, heat to 120°C to recover ethanol; then add 5kg of ethyl acetate as unsaponifiable extractant for extraction, separate the upper layer extract, and under 0.01atm vacuum condition, heat to 120°C for recovery Extractant, obtain 450g remaining liquid matter and be exactly the present invention Hevea brasiliensi...

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PUM

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Abstract

The invention discloses a substance for lowering blood lipid and a preparation method and application thereof. The substance is the unsaponifiable matter of the fat-soluble substance of the seeds of Hevea brasiliensis. The preparation method includes: using the fat-soluble substance extracted from the seeds of Hevea brasiliensis as the raw material, subjecting the raw material to saponification, and performing separation and purification to obtain the substance which does not participate in the saponification. The substance used for lowering the blood lipid of patients with hyperlipidemia is applicable to drugs, health-care food and food and free of side effects.

Description

technical field [0001] The invention discloses a blood lipid-lowering substance, application and preparation method thereof, and belongs to the field of medicine and food. Background technique [0002] Hyperlipidemia refers to high levels of blood lipids, including high levels of cholesterol in blood lipids and high levels of triglycerides. The medical community believes that plasma total cholesterol concentration > 5.17mmol / L (200mg / dl) can be defined as hypercholesterolemia, and plasma triglyceride concentration > 2.3mmol / L (200mg / dl) is hypertriglyceridemia. Hyperlipidemia can directly cause a series of diseases and seriously endanger human health. [0003] Currently available lipid-lowering substances are divided into two categories: medicine and food. Drugs such as statins, niacin, fibrates, etc., but they all have different degrees of side effects, and only have a good effect on one of hypercholesterolemia or hypertriglyceridemia; the main food It is omega-3 f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P3/06A61K131/00
Inventor 徐爽
Owner 徐爽
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