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Bone substitute and independent injection system

A technology of syringes and compositions, applied in the field of bone substitutes, bone filling under mechanical stress, capable of solving problems such as difficulties, device discarding, failure to continue, etc.

Active Publication Date: 2019-05-24
泰克尼梅德公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All of these operations must be performed while remaining sterile and virus-free, which is difficult or expensive with bulky and complex equipment
Once used as described above, the device is discarded
Also, by the surgeon having to interrupt the surgical procedure during use, the injection cannot continue because polymerization is irreversible

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0134] Measurement of Rheological Properties

[0135] The equipment used included:

[0136] -MCR51 rheometer

[0137] -3-EC-02 climate chamber (SLH100-Secasi)

[0138] -RheoPlus software

[0139] The tests for measuring the viscosity of polycaprolactone polymers were performed using Anton Paar MCR51 Rheometer / Viscometer in dynamic shear mode (1 Hz). The device can record the evolution of complex viscosity as a function of time and at constant temperature. In order to approximate the actual use conditions of the heated syringe, the polymer is melted at 90°C in the device and then fixed at a temperature set point (the temperature at which the material will reach the bone site to be filled). When the desired temperature (50° C.) of the support has stabilized, start taking measurements.

Embodiment 2

[0141] Composition of PCL + calcium phosphate containing strontium

[0142] Strontium PCLβ-TCP having a molecular weight of Mn=30,000 g / mol

[0143] than PCL / calcium phosphate

[0144] PCL / β-TCP(Sr)=70 / 30

[0145] Particle size of calcium phosphate

[0146] Β-TCP(Sr)=30μm

[0147] Injection Devices / Syringes

[0148] Injection device according to the invention having a metal cartridge filled with a PCL / TCP(Sr) rod connected to an 11 gauge cannula insertable into a 10 gauge trocar. The device was heated at 90°C in a temperature-regulated heating chamber before it was transferred for injection into the spine.

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Abstract

The invention relates to the field of bioresorbable or non-bioresorbable bone substitutes to be implanted in humans in order to reconstitute the bone supply by replacing lost bone substance. More particularly, the invention is directed to a device that is easy to manufacture and use and comprises a syringe provided with a single-use dose of a polymer which is fluid at the injection temperature while being solid and resistant at body temperature.

Description

technical field [0001] The present invention relates to the field of bioabsorbable or non-bioabsorbable bone substitutes to be implanted in the human body in order to reconstitute bone supplements by replacing missing bone mass. [0002] The invention relates in particular to the field of bone filling under mechanical stress. Background technique [0003] Osteoporosis is a major medical problem and increasingly a major economic problem. More than one-third of 50-year-old women and about one in seven 50-year-old men will suffer a fracture secondary to osteoporosis in their lifetime. [0004] Vertebral fractures are the most common. The first percutaneous vertebroplasty was performed in 1984. Galibert et al. treated cervical hemangiomas percutaneously and filled the vertebral body with polymethylmethacrylate (PMMA) cement. In recent years, vertebroplasty has been gradually recognized in the treatment of osteoporotic vertebral fractures. [0005] Vertebroplasty consists in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/46A61B17/88A61L31/00
CPCA61B17/8802A61B17/8836A61L27/16A61L27/46A61L2400/06A61L2430/02C08L67/04A61B17/3472A61B17/8825A61B17/8855A61L29/02A61L31/00A61B17/8805A61F2/4601A61L27/12
Inventor 朱利恩·伊挨赫尔戈蒂埃·哈尔宾西里尔·森德瑙雷丁·萨赫拉奥伊
Owner 泰克尼梅德公司
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