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Methods and kits for detecting kawasaki disease and methods for treating kawasaki disease

一种川崎氏病、套组的技术，应用在胞嘧啶低甲基化检测川崎氏病领域，能够解决难诊断川崎氏病等问题

Active Publication Date: 2019-05-28
KAOHSIUNG CHANG GUNG MEMORIAL HOSPITAL
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

In infected children, clinicians have difficulty accurately diagnosing Kawasaki disease and administering IVIG rapidly to prevent coronary artery disease

Method used

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  • Methods and kits for detecting kawasaki disease and methods for treating kawasaki disease
  • Methods and kits for detecting kawasaki disease and methods for treating kawasaki disease
  • Methods and kits for detecting kawasaki disease and methods for treating kawasaki disease

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Embodiment Construction

[0023] As used herein, the articles "a" and "an" refer to one or more (i.e., at least one) of the grammatical object of the article.

[0024] The term "subject" may refer to a vertebrate suspected of having Kawasaki's disease. Individuals include warm-blooded animals, such as mammals, such as primates, and preferably humans. Nonhuman primates are also individuals. The term individual includes domesticated animals such as cats, dogs, etc., domestic animals (eg, cows, horses, pigs, sheep, goats, etc.), and experimental animals (eg, mice, rabbits, rats, gerbils, guinea pigs, etc. ).

[0025] As used herein, "sample" refers to a composition containing the material to be tested, and includes, for example, "biological samples," which refer to samples obtained from, for example, humans or other mammals that may suffer from Kawasaki's disease. Any material obtained from living sources such as A biological sample may be in any form comprising solid material such as tissue, cells, c...

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Abstract

The present invention relates to methods that use novel biomarkers for diagnosing and / or treating Kawasaki diseases. The novel biomarkers of the invention show altered cytosine methylations state of certain CpG loci in subjects with Kawasaki Disease relative to subjects without Kawasaki diseases. Also provided are kits comprising at least one primer or reagent specific for the altered cytosine methylation state of certain CpG loci to detect Kawasaki Disease.

Description

[0001] Cross-references to related applications [0002] This application claims the benefit of U.S. Application No. 62 / 589,345, filed November 21, 2017, the disclosure of which is hereby incorporated by reference. technical field [0003] The present invention relates to the detection of Kawasaki's disease by cytosine hypomethylation of CpG double nucleotides and the method for treating Kawasaki's disease. Background technique [0004] Kawasaki's disease (KD), also known as mucocutaneous lymph node syndrome of unknown etiology, is an acute childhood vasculitis syndrome affecting both small and medium-sized vessel walls (vasculitis), especially the coronary arteries. The incidence of Kawasaki disease in Asian children is more than 10 times that of American and European children. [0005] The early and most obvious symptom of Kawasaki disease is fever for at least 5 days. If left untreated, serious coronary complications can result, including coronary artery dilatation, fis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q2600/154A61P9/00C12Q2600/156C12Q1/6883A61K2039/505C07K16/06A61K2039/55G01N33/6893G01N2333/4703G01N2800/328C12Q1/6816C12Q1/6851C12Q2600/158
Inventor 黄瀛贤郭和昌
Owner KAOHSIUNG CHANG GUNG MEMORIAL HOSPITAL
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