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Application of preparation of dry eye medicine and method for treating dry eye

A technology of inhibitors and nano-formulations, applied in the field of dry eye, can solve problems such as low bioavailability

Active Publication Date: 2021-07-30
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Due to the structural properties of the eyeball, traditional ocular surface drug delivery has low bioavailability resulting in >90%

Method used

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  • Application of preparation of dry eye medicine and method for treating dry eye
  • Application of preparation of dry eye medicine and method for treating dry eye
  • Application of preparation of dry eye medicine and method for treating dry eye

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Embodiment Construction

[0014] Combine now figure 1 , figure 2 , image 3 , Figure 4 The present invention is further described,

[0015] 1) Dry eye model

[0016] 72 healthy C57BL / 6 mice aged 4-6 weeks, female, without ocular surface infection and inflammation, without old leukoplakia, and with a corneal fluorescein sodium staining score of less than 10 (provided by the Experimental Animal Center of Wenzhou Medical University, after Approved by the Experimental Animal Ethics Committee of Wenzhou Medical University.). 64 mice were raised in an intelligent environment control system (relative humidity 15±3%, wind speed 2.1±0.2 m / s, temperature 21-23 ℃) as experimental groups for different interventions (6 mice in each group treated for 3 days, 1-week treatment group (2 mice in each group); 8 mice were raised in a normal environment without any treatment as the normal control group (NC). In the breeding environment, the light is irradiated from the ceiling above to the ground below, and the ill...

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Abstract

An application for preparing a dry eye drug and a method for treating dry eye, through targeted delivery of intraocular oxygen free radical (ROS) inhibitors to mitochondria, through improving the translocation efficiency of exogenous antioxidants across cell membranes, and making Oxygen free radical (ROS) inhibitors are enriched in mitochondria or around mitochondria, clearing ROS in mitochondria in situ, inhibiting ROS imbalance from the source, and then blocking the signaling pathways that produce ocular inflammation can finally effectively inhibit ROS imbalance from the source Inhibit the occurrence of dry eye.

Description

technical field [0001] The invention specifically relates to the technical field of dry eye syndrome, in particular to an application for preparing a medicine for dry eye syndrome and a method for treating dry eye syndrome. Background technique [0002] Dry eye is a clinically common eye disease, also known as keratoconjunctival sicca. Epidemiological studies have shown that with the aging of the society, the increase in the use of video terminals, the increasingly serious environmental pollution, and the increase in the incidence of diabetes, the number of dry eye cases worldwide is rising sharply. Among the middle-aged and elderly people aged 50 and above in the world, the incidence of dry eye is about 5.5%-33.7%. Dry eye clinically manifests as dry eyes, easy fatigue, itchy eyes, foreign body sensation, burning sensation, sticky secretions, Fear of wind, photophobia, sensitivity to external stimuli, etc.; severe cases can lead to redness and swelling of the eyes, hyperem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/728A61K31/662A61P27/02
Inventor 陈蔚郑钦象李玲林森葛超翔
Owner WENZHOU MEDICAL UNIV