32 results about "Eyes inflammation" patented technology

The invention relates to recombinant III-type humanized collagen and application of a composition containing the same to eyes. The invention provides an application of recombinant III type humanized collagen in preparation of a product for preventing and / or treating eye inflammation, a composition containing the recombinant III type humanized collagen, and an application of the composition in preparation of a product for preventing and / or treating eye inflammation and / or eye dryness. The recombinant III-type humanized collagen and the composition containing the recombinant III-type humanized collagen can obviously promote updating and repairing of corneal epithelial cells, and meanwhile, can inhibit release of inflammatory mediators, enhance eye tissue barriers, enhance tear film stability and relieve eye inflammation and eye dryness.

The utility model provides a glaucoma drainage device, and relates to the technical field of medical instruments. The glaucoma drainage device comprises a base body, a first hydrophilic layer and a second hydrophilic layer, the base body is provided with a channel penetrating through the base body in the first preset direction. The base body is provided with a first end face and a second end face which are oppositely arranged in the first preset direction. The first hydrophilic layer covers the first end surface and the second end surface; the inner wall of the channel is at least partially covered by the second hydrophilic layer. According to the glaucoma drainage device, accumulation and adhesion of substances such as protein, cells and bacteria in aqueous humor at a channel opening and in a channel can be reduced, the blocking risk of the channel is reduced, the eye aqueous humor can be better led out, intraocular pressure is reduced, and the inflammatory response of eyes can be reduced.

The eye drops are prepared from the following components in percentage by mass: 0.1 percent to 0.5 percent of chondroitin sulfate, 0.06 percent to 0.3 percent of sericin protein nanoparticles containing astaxanthin, 0.1 percent to 0.3 percent of sodium hyaluronate, 0.05 percent to 0.1 percent of vitamin E, 0.9 percent to 1.0 percent of sodium chloride, 0.05 percent to 0.1 percent of poloxamer, 0.01 percent to 0.1 percent of EDTA (Ethylene Diamine Tetraacetic Acid), a phosphate buffer solution and the balance of water, wherein the particle size of the sericin nano-particles containing the astaxanthin is 50 to 300 nm; the phosphate buffer solution is used for adjusting the pH value of the eye drops to 6.8-7.9. The eye drops can effectively relieve the dry eye symptom, provide long-time wetting and protection, reduce eye inflammation and oxidative stress, remarkably improve the dry eye symptom and are high in use safety.

This invention provides a traditional Chinese medicine composition and its application in the preparation of a topical herbal eye patch for treating thyroid eye diseases, belonging to the field of biomedical technology. The herbal composition consists of *Gynostemma pentaphyllum*, peppermint, *Platycladus orientalis* leaves, borneol, cicada slough, *Astragalus membranaceus*, *Selaginella tamariscina*, *Pteris vittata*, *Scutellaria baicalensis*, apricot leaf, and *Ipomoea aquatica*. Using this herbal composition as raw material, a topical herbal eye patch is prepared. This patch acts directly on acupoints and skin around the eyes, allowing the medicinal properties to penetrate the skin and reach the eye system, achieving the effects of promoting blood circulation, clearing heat and detoxifying, invigorating qi and unblocking meridians, reducing swelling and improving vision. It is suitable for the treatment of thyroid-related eye diseases. This invention's topical herbal eye patch can effectively improve clinical symptoms such as exophthalmos and eye inflammation in patients with thyroid eye diseases, positively impacting their quality of life and effectively improving the clinical treatment efficacy of this disease. The topical herbal eye patch provided by this invention can be further promoted and applied in the clinical treatment of thyroid eye diseases.

The invention relates to the technical field of biological medicine, and discloses a tobramycin nano transfer body as well as a preparation method and application thereof. The invention provides a preparation method of a tobramycin nano transfer body, which specifically comprises the following steps: uniformly mixing lipid, a surfactant, xylooligosaccharide and an alcohol solvent, evaporating to remove the alcohol solvent to obtain a film, and hydrating the film with a tobramycin-PBS buffer solution to obtain a suspension; and then carrying out ultrasonic treatment and graded filtration on the suspension to obtain the tobramycin nano transfer body. The tobramycin nano transfer body has the advantages of high stability, capability of effectively improving the permeability of a hydrophilic drug penetrating through a biological barrier, small particle size, small PDI and the like. The tobramycin-in-situ gel prepared by using the tobramycin nano transfer body has good biocompatibility, stable drug loading capacity and controllable drug release performance, can penetrate cornea to reach a focus to play a targeting role, and can be applied to preparation of external preparations for treating ocular inflammation.

The invention discloses eye health care liquid based on cortex berberidis and saffron crocus extracts and a preparation method of the eye health care liquid, and relates to the technical field of traditional Chinese medicine preparations and eye health care, in particular to the eye health care liquid based on the cortex berberidis and saffron crocus extracts and the preparation method of the eye health care liquid. According to the eye health-care liquid, a cortex berberidis extract and a saffron crocus extract are used as main active ingredients, a fructus lycii extract, a radix stemonae extract, a mint extract, a honeysuckle flower extract and other functional ingredients are used as auxiliary ingredients, and sodium hyaluronate, taurine and vitamin B6 are added to enhance the moisturizing, anti-oxidation and metabolic regulation effects. The preparation method comprises the steps of raw material extraction, extract concentration, auxiliary material mixing and pH adjustment, filtration and sterilization and the like. The product is suitable for eye atomization application, has the effects of relieving eye inflammation, improving microcirculation, relieving dryness, redness and swelling and the like, meanwhile strictly controls heavy metal and microbiological indexes, and guarantees use safety.

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri HuYan with an eye protection effect and application of the lactobacillus reuteri HuYan. According to the invention, a novel lactobacillus reuteri HuYan strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, and the lactobacillus reuteri HuYan strain can significantly reduce vascular hyperplasia and cell apoptosis of eyes, inhibit eye shrinkage, reduce the number of neutrophils in the eyes, reduce the content of levodopa and increase the content of levo5-hydroxytryptamine. Therefore, the strain can be applied to prevention and treatment of eye vascular dysplasia related diseases, protection of intraocular cells to avoid apoptosis, improvement or prevention of eye shrinkage and alleviation of eye inflammation, has positive significance in protection of eye tissues and maintenance of normal physiological status of eyes, is expected to be used in the fields related to prevention and treatment of eye diseases, and has wide application prospects. Wide application prospects are realized in the field of treating and preventing eye diseases.

The present invention provides an eye protection liquid for promoting the repair of eye cells and a preparation method thereof, wherein the eye protection liquid comprises the following raw materials in parts by weight: 5-15 parts of sage extract, 10-20 parts of sage extract, 40-60 parts of birch cell extract, 20-30 parts of verbena extract, and 0.3-0.5 parts of geranium essential oil. The antioxidant components contained in the eye protection liquid of the present invention can remove free radicals in eye cells and reduce cell damage. Anti-inflammatory components can reduce eye inflammation and create favorable conditions for the repair and regeneration of eye cells. Ingredients such as sage extract can promote blood circulation in the eye, increase oxygen supply and nutrient supply to eye cells, thereby accelerating the repair and regeneration of eye cells. Ingredients such as birch cell extract can enhance the moisturizing ability of eye cells, improve dry eye symptoms, and provide a moist environment for the repair and regeneration of eye cells. Through the synergistic effect of multiple raw materials, the repair of eye cells is effectively promoted, and eye health problems are fundamentally solved for a long time.

The invention relates to eye drops for treating xerophthalmia and a preparation method of the eye drops. The eye drops are prepared from the following components in percentage by mass: 0.05 to 0.5 percent of a wild mint extract, 0.1 to 0.4 percent of lutein-coated sericin nano-particles, 0.1 to 0.5 percent of chondroitin sulfate, 0.9 to 1.0 percent of sodium chloride, 0.05 to 0.1 percent of poloxamer, 0.01 to 0.1 percent of EDTA (Ethylene Diamine Tetraacetic Acid), a phosphate buffer solution and water. The particle size of the lutein-coated sericin nanoparticles is 50-300nm, the water is medicinal sterile water, and the pH value of the eye drops is adjusted to 7.0-7.8 by the phosphate buffer solution. The eye drops can effectively relieve dry eye symptoms, provide long-time wetting and protection, reduce eye inflammation and oxidative stress, promote repair of corneal injury and effectively reduce the expression level of inflammatory factors, and are high in use safety.

The invention belongs to the technical field of pet supplies, and particularly discloses a composition and application thereof in preparation of a product for reducing pet tear stains, the composition can effectively reduce the tear stains, and the composition, the composition and the product all have certain anti-inflammatory effects and jointly reduce tear secretion and inflammation-related tear stains. Meanwhile, the althaea rosea extract can improve the availability of hydroxytyrosol and fucoidan polysaccharide sulfate, improve eye microcirculation and relieve eye fatigue and dryness, fucoidan polysaccharide sulfate reduces iron elements entering tears through portal vein circulation and blocks generation of porphyrin-iron compounds, hydroxytyrosol improves metabolism and accelerates ferriporphyrin metabolism, and the effect of improving eye quality is achieved. The althaea officinalis extract promotes biliary secretion and accelerates ferriporphyrin metabolism, the synergistic interaction of the althaea officinalis extract, the althaea officinalis extract, the ferriporphyrin and the althaea officinalis extract can effectively reduce formation of tear stains, the risk of eye inflammation and bacterial infection is reduced, immunity can be improved, blood circulation can be promoted, and finally the pet is helped to keep a clean and healthy eye environment.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a meloxicam solution type ophthalmic preparation without a bacteriostatic agent and a tackifier as well as a preparation method and application of the meloxicam solution type ophthalmic preparation. The ophthalmic preparation is prepared from the following components in percentage by mass / volume: 0.05 to 0.5 percent of meloxicam or medicinal salt thereof, 1.0 to 10.0 percent of solubilizer, 0.067 to 2.0 percent of pH (Potential of Hydrogen) regulator, 0.1 to 2.0 percent of osmotic pressure regulator and water for injection, the solubilizing agent is one or two of hydroxypropyl beta-cyclodextrin and sulfobutyl beta-cyclodextrin, and the solubilizing agent is one or two of hydroxypropyl beta-cyclodextrin and sulfobutyl beta-cyclodextrin. The pH value of the ophthalmic preparation is 7.0-8.5, and the osmotic pressure molar concentration of the ophthalmic preparation is 250-450 mOsmol / kg. The ophthalmic preparation disclosed by the invention is not added with a bacteriostatic agent and a tackifier, has the advantages of better anti-inflammatory effect, no irritation, good compliance and safety, and easiness in industrial production of the preparation method, and can be used for treating eye inflammation.

The present application relates to a kind of dry eye drops, it includes by mass percentage: chondroitin sulfate 0.1%-0.5%, silk fibroin nanoparticles containing astaxanthin 0.06%-0.3%, sodium hyaluronate 0.1%-0.3%, vitamin E 0.05%-0.1%, sodium chloride 0.9-1.0%, poloxamer 0.05%-0.1%, EDTA 0.01%-0.1%, phosphate buffer and the balance of water;Wherein, the silk fibroin nanoparticles containing astaxanthin particle size is 50-300nm;Phosphate buffer is adjusted to 6.8-7.9 to the pH of eye drop.The eye drop of the present application can effectively relieve dry eye symptoms, provide long time wet and protection, while reducing eye inflammation and oxidative stress, significantly improve dry eye, and high use safety.

The present invention relates to use of a recombinant type III humanized collagen and a composition comprising the same in an eye. Provided are use of a recombinant type III humanized collagen in the preparation of a product for preventing and / or treating eye inflammation, a composition comprising the recombinant type III humanized collagen, and use of the composition in the preparation of a product for preventing and / or treating eye inflammation and / or eye dryness. The recombinant type III humanized collagen and the composition comprising the same can significantly promote the renewal and repair of corneal epithelial cells, and can also inhibit the release of inflammatory mediators, enhancing the ocular tissue barrier, enhancing tear film stability, and alleviating eye inflammation and eye dryness.

The invention belongs to the technical field of traditional Chinese medicines, particularly relates to eye drops and a preparation method thereof, and adopts the technical scheme that the eye drops are prepared from calyx seu fructus physalis and purified water. The calyx seu fructus physalis in the components of the eye drops has a natural anti-inflammatory attribute, so that the eye drops are beneficial to relieving eye inflammation and discomfort, improving eye health and improving eyesight; the eye drops are only prepared from calyx seu fructus physalis and water, so that the use of chemical additives is reduced, and the eye drops are more natural, safer and suitable for long-term use; the calyx seu fructus physalis extract in the eye drops can help to keep eyes moist, prevent xerophthalmia and improve the comfort level of a user; due to the natural component formula, the eye drops are mild and non-irritant, and are suitable for sensitive people and users who often use the eye drops.

The application discloses a synthesis method and application of a cyclic hexapeptide scleramide, and the structure of the cyclic hexapeptide scleramide is as follows: the cyclic hexapeptide scleramide is coupled with FMOC-Gln(trt)-N-Me-Phe, FMOC-glycine, FMOC-N-methyl-L-phenylalanine and FMOC-L-phenylalanine in the order from the C terminal to the N terminal of the cyclic peptide sequence of the cyclic hexapeptide scleramide in the presence of a condensation reagent and an organic base by using glycine-resin, and then the protecting group is removed by using an organic base, so that the amino acid sequence, the cyclization mode and the modification site can be accurately controlled through solid-phase / liquid-phase synthesis technology, the efficient preparation of the cyclic hexapeptide scleramide compound is realized, and the limitation of a natural source is broken; meanwhile, the compound has significant anti-inflammatory activity, and provides an alternative compound for developing a new eye inflammation drug.

The invention discloses pranoprofen eye drops and a preparation method thereof, and the pranoprofen eye drops are prepared from the following components in parts by weight: 20-30 parts of pranoprofen, 20-30 parts of glucocorticoid, 5-20 parts of taurine, 5-20 parts of glucose, 5-20 parts of sodium hyaluronate, 5-20 parts of polyvinyl alcohol, 5-20 parts of boric acid and 5-20 parts of a surfactant. The sodium hyaluronate and the polyvinyl alcohol are added into the eye drops, and the sodium hyaluronate is a viscoelastic glycoprotein and has lubricating and anti-inflammatory effects; polyvinyl alcohol is artificial tears and is mainly used for treating eye dryness and foreign body sensation caused by xerophthalmia, the situation that due to long-term use, normal flora imbalance of eyes is caused, the symptom of eye inflammation is aggravated, and the experience feeling of a user is improved is avoided; the taurine and the glucocorticoid are added into the eye drops, and the taurine has the effects of clearing away heat and toxic materials and relieving asthenopia, so that the comfort of the eye drops dropped into eyes is improved.

Use of a bioactive substance for the preparation of an ophthalmic health and / or anti-inflammatory composition, wherein the bioactive substance is a peptide having an amino acid sequence as set forth in SEQ ID NO: 1, wherein the amino acid sequence is a fragment of a bovine skin peptide; wherein the composition is used to reduce the expression level of at least one of an inflammation-related gene comprising a vascular endothelial growth factor A gene, an interleukin-1β gene, and an interleukin-8 gene.

The invention discloses a medicine for treating eye inflammation of caged grey birds and a use method of the medicine. 1 part of lactic acid levofloxacin eye drops and 9 parts of normal saline are prepared; 1 part of lactic acid levofloxacin eye drops and 9 parts of normal saline are mixed, and a mixed solution with the concentration being 10% is prepared. The method is simple, convenient and easy to implement in the aspect of medicine preparation, high in operability and capable of effectively treating infection of eye inflammation of the grey birds. Through long-term observation, after the mixed solution is dripped into the gray bird with eye inflammation, the body health and daily behaviors of the gray bird are not obviously influenced. By means of the method, the number of the gray birds with eye inflammation is effectively reduced, the breeding economic benefits are improved, and meanwhile the breeding risk and cost are reduced.

The application provides a kind of nano preparation with antioxidant function and the use for treating glaucoma, the preparation is composed of oil phase and water phase.Oil phase is lecithin, medium-chain triglyceride, fat-soluble antioxidant, glaucoma treatment drug, water phase is water-soluble antioxidant or deionized water.The nano delivery system described in the application is by loading glaucoma treatment drug in the nano preparation containing antioxidant, can improve local drug concentration, prolong drug retention time, at the same time, through antioxidant scavenging excess active oxygen, reduce inflammatory response, reduce eye cell apoptosis, so as to achieve good therapeutic effect.The nano preparation described in the application can be nano emulsion, liposome, micelle or lipid nanoparticle and other drug delivery systems.The nano preparation can deliver therapeutic drugs while scavenging ROS, reducing eye inflammation and reducing cell apoptosis to achieve more efficient therapeutic effect, with the characteristics of double effect, easy to produce and prepare, wide application range, etc.

The present invention relates to a composition for preventing or treating ocular diseases, comprising Aloe vera gel. Specifically, when orally administered, the Aloe vera (A.vera) gel has been confirmed to have an excellent effect of increasing the expression of genes related to the improvement of tear volume, corneal non-uniformity, eye inflammation, dry eye, corneal thickness, and tear film. Accordingly, the Aloe vera gel can be advantageously used as an active ingredient in an oral composition for the prevention, alleviation, or treatment of ocular diseases, including dry eye syndrome.

The invention relates to the technical field of traditional Chinese medicine eye-protecting eye drops, in particular to a traditional Chinese medicine eye-protecting eye drop formula and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The eye drops are composed of carbomer, glycerin, xanthophyll and 25 traditional Chinese medicine extracts, solubility is improved through a grouping dissolution process, and sterility is guaranteed through three-stage filtration and hot-pressing sterilization. The preparation method comprises the following steps: preparing the carbomer gel matrix, premixing glycerol and xanthophyll, redissolving the traditional Chinese medicine extract, adjusting the pH value of the main liquid medicine to 6.5-7.5, storing in a dark place under nitrogen charging and the like. The pH value of the product is 7.0 + / -0.2, the viscosity is 15-25 mPa.s, the osmotic pressure is 280-320 mOsm / kg, and the stability reaches 24 months. The problems that traditional Chinese medicine eye drops are prone to precipitation, the process is unstable and microbial contamination is caused are solved, and the eye drops are suitable for relieving eyestrain, xerophthalmia and eye inflammation and have the advantages of being natural, mild and small in side effect.

The invention discloses gatifloxacin eye drops and a preparation method of the gatifloxacin eye drops. According to the present invention, the antioxidant in the product is L-cysteine as the natural antioxidant in the body, and the free radical is removed through the reduction reaction so as to achieve the anti-oxidation effect, such that the anti-oxidation effect is provided, the anti-aging effect is provided, the anti-aging effect is good, and the anti-aging effect is good. The situation that the preservative generates chemical reaction at the conjunctiva and the cornea, the conjunctiva and the cornea are damaged, and anaphylactic reaction is caused is avoided; the pearl powder and the natural borneol are added, the pearl powder has the effects of clearing away heat and toxic materials, nourishing the liver and improving eyesight, the natural borneol inhibits release of inflammatory mediators in tissues so as to relieve eye inflammation and red and swollen, and meanwhile, the natural borneol has an analgesic effect by stimulating eye cold receptors, so that eye pain is relieved, and the comfort of a user is improved.

The invention relates to the field of albumin binding type drugs, in particular to a cyclosporin A entrapped albumin binding type drug as well as a preparation method and application thereof. The albumin binding type medicine comprises cyclosporin A or a derivative thereof and albumin, the mass ratio of the cyclosporin A or the derivative thereof to the albumin is 1: (1-10), and albumin molecules are connected through disulfide bonds formed by self-crosslinking of free sulfydryl of the albumin. The albumin combined medicine disclosed by the invention shows a remarkable curative effect in the aspect of treating xerophthalmia, and can be used for remarkably improving tear secretion and quality, effectively repairing corneal injury, relieving eye inflammation and promoting overall recovery of eye tissues. According to the albumin binding type medicine, the retention time of the medicine on the ocular surface can be remarkably prolonged, the local medicine concentration is improved, the eye tissue recovery is comprehensively promoted while symptoms are rapidly relieved, and good safety and potential clinical application value are shown.

The invention discloses an active aldehyde substance inhibitor based on AI design and application thereof. The active aldehyde substance inhibitor comprises a compound shown in a general formula (I) or a derivative thereof, and in the general formula (I), R1 and R2 are independently selected from any one of hydrogen, C2-6 unsaturated alkyl, C1-6 alkoxy, C2-6 halogenated alkyl, halogen, amino, C3-20 cycloalkyl or heterocyclic radical with 4-20 ring atoms; x is carbon or nitrogen; the derivative comprises at least one of a fluorescent marker, a spin marker, a heavy metal marker, an isotope marker and pharmaceutically acceptable salt. The active aldehyde substance (RASP) inhibitor provided by the invention has better capability and speed of complexing aldehyde, and can be quickly and effectively complexed with the active aldehyde substance after being applied to a diseased region, so that the content of RASP in the diseased region is reduced, and further, eye inflammation is reduced or avoided; the eye drops have potential prevention or treatment effects on various eye inflammatory diseases such as xerophthalmia and the like.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing ox gall, a pharmaceutical preparation and application, the present application provides a traditional Chinese medicine composition containing ox gall, which has the effects of clearing heat and resolving toxins, cooling liver and resolving lung, dispersing wind and relieving pain, and the preparation has a wide range of uses, the preparation method of the composition provided by the present application is easy to operate, and through years of production practice accumulation, the quality of the obtained product is stable and controllable, and the product is used for preparing drugs for treating liver and lung heat accumulation, wind and fire disturbance, dizziness, oral and nasal sores, wind and fire toothache, sudden eye inflammation, skin itching and other diseases in clinic, and has a wide application value.

The invention relates to the use of an 11β-HSD1 pathway activity inhibitor in the preparation of a drug for treating glaucomatous cyclitis syndrome. By specifically inhibiting 11β-HSD1 activity in the eye, the drug can effectively correct the imbalance of local corticosteroid metabolism in the eye, alleviate the physiological effects of excess mineralocorticoids, and simultaneously reduce aqueous humor production and alleviate eye inflammation. The drug is suitable for treating glaucomatous cyclitis syndrome and other diseases related to increased 11β-HSD1 activity in the eye. The invention has the advantages of novel targets, high efficiency and safety, and long-term intraocular pressure reduction, and has important clinical application value.

The invention belongs to the technical field of eye drops, and particularly relates to pure traditional Chinese medicine eye drops prepared by an ancient method for treating eye inflammation and a preparation method. The eyedrops are prepared from the following components: 10 to 40 parts of honeysuckle flower, 5 to 30 parts of flos eriocauli, 8 to 20 parts of flos buddlejae, 8 to 16 parts of spica prunellae, 5 to 14 parts of herba equiseti hiemalis and 1 to 5 parts of menthol. An ancient-method processing technology and a mechanochemical method extraction technology are combined, the ancient-method processing is used for directionally enhancing release of effective components through targeted activation of channel tropism attributes of medicinal materials, and the mechanochemical method utilizes high-energy ball milling and chemical reaction to accurately destroy a plant cell wall structure and remarkably improve the dissolution efficiency of medicinal material components; the medicine effect is obviously improved.

The invention belongs to the technical field of ophthalmology medical equipment, and particularly relates to a wet chamber mirror suitable for thyroid-related eye diseases, which comprises a wet chamber mirror body, a storage box is fixedly installed on one face of the wet room mirror body, a micro water pump is fixedly installed in the storage box, a connecting pipe is fixedly installed at the output end of the micro water pump, two liquid outlet pipes are fixedly installed at the end, away from the micro water pump, of the connecting pipe, and a liquid inlet pipe with a one-way valve is fixedly installed on one face of the storage box. A weight box is fixedly installed on the face, away from the storage box, of the room wetting mirror body. A micro water pump in the storage box is started through a control button, so that the water pump conveys purified water in the storage box into the corresponding fixing frames through a connecting pipe and two liquid outlet pipes respectively, and the purified water is sprayed to eyes of a patient through liquid outlet holes of the fixing frames, so that discomfort such as dryness of the eyes of the patient is relieved, aggravation of eye inflammation of the patient is effectively avoided, and the patient's eye quality is improved. And the vicious circle is avoided.

The invention relates to an application of wild chrysanthemum flower flavone in preparation of a product for preventing, treating and / or relieving D-GalN / LPS induced liver and eye injury. Researchers find that wild chrysanthemum flower flavone can relieve the iris congestion symptom, reduce the content of serum, liver and retina inflammatory factors and relieve eye inflammation infiltration through research, and it is indicated that wild chrysanthemum flower flavone can relieve and treat D-GalN / LPS induced liver and eye injuries. The application provides a new application for wild chrysanthemum flower flavone, and provides a new product for preventing, treating and / or relieving D-GalN / LPS induced liver and eyes. Research finds that when the wild chrysanthemum flower flavone is applied to preparation of products for preventing, treating and / or relieving D-GalN / LPS-induced liver and eye injuries, the drug effect is obvious, the application prospect is wide, and the wild chrysanthemum flower flavone has relatively high popularization and application values.

A process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions may be used in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.