24 results about "Eyes inflammation" patented technology

The invention relates to recombinant III-type humanized collagen and application of a composition containing the same to eyes. The invention provides an application of recombinant III type humanized collagen in preparation of a product for preventing and / or treating eye inflammation, a composition containing the recombinant III type humanized collagen, and an application of the composition in preparation of a product for preventing and / or treating eye inflammation and / or eye dryness. The recombinant III-type humanized collagen and the composition containing the recombinant III-type humanized collagen can obviously promote updating and repairing of corneal epithelial cells, and meanwhile, can inhibit release of inflammatory mediators, enhance eye tissue barriers, enhance tear film stability and relieve eye inflammation and eye dryness.

This invention provides a traditional Chinese medicine composition and its application in the preparation of a topical herbal eye patch for treating thyroid eye diseases, belonging to the field of biomedical technology. The herbal composition consists of *Gynostemma pentaphyllum*, peppermint, *Platycladus orientalis* leaves, borneol, cicada slough, *Astragalus membranaceus*, *Selaginella tamariscina*, *Pteris vittata*, *Scutellaria baicalensis*, apricot leaf, and *Ipomoea aquatica*. Using this herbal composition as raw material, a topical herbal eye patch is prepared. This patch acts directly on acupoints and skin around the eyes, allowing the medicinal properties to penetrate the skin and reach the eye system, achieving the effects of promoting blood circulation, clearing heat and detoxifying, invigorating qi and unblocking meridians, reducing swelling and improving vision. It is suitable for the treatment of thyroid-related eye diseases. This invention's topical herbal eye patch can effectively improve clinical symptoms such as exophthalmos and eye inflammation in patients with thyroid eye diseases, positively impacting their quality of life and effectively improving the clinical treatment efficacy of this disease. The topical herbal eye patch provided by this invention can be further promoted and applied in the clinical treatment of thyroid eye diseases.

The invention relates to the technical field of biological medicine, and discloses a tobramycin nano transfer body as well as a preparation method and application thereof. The invention provides a preparation method of a tobramycin nano transfer body, which specifically comprises the following steps: uniformly mixing lipid, a surfactant, xylooligosaccharide and an alcohol solvent, evaporating to remove the alcohol solvent to obtain a film, and hydrating the film with a tobramycin-PBS buffer solution to obtain a suspension; and then carrying out ultrasonic treatment and graded filtration on the suspension to obtain the tobramycin nano transfer body. The tobramycin nano transfer body has the advantages of high stability, capability of effectively improving the permeability of a hydrophilic drug penetrating through a biological barrier, small particle size, small PDI and the like. The tobramycin-in-situ gel prepared by using the tobramycin nano transfer body has good biocompatibility, stable drug loading capacity and controllable drug release performance, can penetrate cornea to reach a focus to play a targeting role, and can be applied to preparation of external preparations for treating ocular inflammation.

The invention discloses eye health care liquid based on cortex berberidis and saffron crocus extracts and a preparation method of the eye health care liquid, and relates to the technical field of traditional Chinese medicine preparations and eye health care, in particular to the eye health care liquid based on the cortex berberidis and saffron crocus extracts and the preparation method of the eye health care liquid. According to the eye health-care liquid, a cortex berberidis extract and a saffron crocus extract are used as main active ingredients, a fructus lycii extract, a radix stemonae extract, a mint extract, a honeysuckle flower extract and other functional ingredients are used as auxiliary ingredients, and sodium hyaluronate, taurine and vitamin B6 are added to enhance the moisturizing, anti-oxidation and metabolic regulation effects. The preparation method comprises the steps of raw material extraction, extract concentration, auxiliary material mixing and pH adjustment, filtration and sterilization and the like. The product is suitable for eye atomization application, has the effects of relieving eye inflammation, improving microcirculation, relieving dryness, redness and swelling and the like, meanwhile strictly controls heavy metal and microbiological indexes, and guarantees use safety.

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri HuYan with an eye protection effect and application of the lactobacillus reuteri HuYan. According to the invention, a novel lactobacillus reuteri HuYan strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, and the lactobacillus reuteri HuYan strain can significantly reduce vascular hyperplasia and cell apoptosis of eyes, inhibit eye shrinkage, reduce the number of neutrophils in the eyes, reduce the content of levodopa and increase the content of levo5-hydroxytryptamine. Therefore, the strain can be applied to prevention and treatment of eye vascular dysplasia related diseases, protection of intraocular cells to avoid apoptosis, improvement or prevention of eye shrinkage and alleviation of eye inflammation, has positive significance in protection of eye tissues and maintenance of normal physiological status of eyes, is expected to be used in the fields related to prevention and treatment of eye diseases, and has wide application prospects. Wide application prospects are realized in the field of treating and preventing eye diseases.

The invention belongs to the technical field of pet supplies, and particularly discloses a composition and application thereof in preparation of a product for reducing pet tear stains, the composition can effectively reduce the tear stains, and the composition, the composition and the product all have certain anti-inflammatory effects and jointly reduce tear secretion and inflammation-related tear stains. Meanwhile, the althaea rosea extract can improve the availability of hydroxytyrosol and fucoidan polysaccharide sulfate, improve eye microcirculation and relieve eye fatigue and dryness, fucoidan polysaccharide sulfate reduces iron elements entering tears through portal vein circulation and blocks generation of porphyrin-iron compounds, hydroxytyrosol improves metabolism and accelerates ferriporphyrin metabolism, and the effect of improving eye quality is achieved. The althaea officinalis extract promotes biliary secretion and accelerates ferriporphyrin metabolism, the synergistic interaction of the althaea officinalis extract, the althaea officinalis extract, the ferriporphyrin and the althaea officinalis extract can effectively reduce formation of tear stains, the risk of eye inflammation and bacterial infection is reduced, immunity can be improved, blood circulation can be promoted, and finally the pet is helped to keep a clean and healthy eye environment.

The present application relates to a kind of dry eye drops, it includes by mass percentage: chondroitin sulfate 0.1%-0.5%, silk fibroin nanoparticles containing astaxanthin 0.06%-0.3%, sodium hyaluronate 0.1%-0.3%, vitamin E 0.05%-0.1%, sodium chloride 0.9-1.0%, poloxamer 0.05%-0.1%, EDTA 0.01%-0.1%, phosphate buffer and the balance of water;Wherein, the silk fibroin nanoparticles containing astaxanthin particle size is 50-300nm;Phosphate buffer is adjusted to 6.8-7.9 to the pH of eye drop.The eye drop of the present application can effectively relieve dry eye symptoms, provide long time wet and protection, while reducing eye inflammation and oxidative stress, significantly improve dry eye, and high use safety.

The present invention relates to use of a recombinant type III humanized collagen and a composition comprising the same in an eye. Provided are use of a recombinant type III humanized collagen in the preparation of a product for preventing and / or treating eye inflammation, a composition comprising the recombinant type III humanized collagen, and use of the composition in the preparation of a product for preventing and / or treating eye inflammation and / or eye dryness. The recombinant type III humanized collagen and the composition comprising the same can significantly promote the renewal and repair of corneal epithelial cells, and can also inhibit the release of inflammatory mediators, enhancing the ocular tissue barrier, enhancing tear film stability, and alleviating eye inflammation and eye dryness.

The application discloses a synthesis method and application of a cyclic hexapeptide scleramide, and the structure of the cyclic hexapeptide scleramide is as follows: the cyclic hexapeptide scleramide is coupled with FMOC-Gln(trt)-N-Me-Phe, FMOC-glycine, FMOC-N-methyl-L-phenylalanine and FMOC-L-phenylalanine in the order from the C terminal to the N terminal of the cyclic peptide sequence of the cyclic hexapeptide scleramide in the presence of a condensation reagent and an organic base by using glycine-resin, and then the protecting group is removed by using an organic base, so that the amino acid sequence, the cyclization mode and the modification site can be accurately controlled through solid-phase / liquid-phase synthesis technology, the efficient preparation of the cyclic hexapeptide scleramide compound is realized, and the limitation of a natural source is broken; meanwhile, the compound has significant anti-inflammatory activity, and provides an alternative compound for developing a new eye inflammation drug.

The invention discloses pranoprofen eye drops and a preparation method thereof, and the pranoprofen eye drops are prepared from the following components in parts by weight: 20-30 parts of pranoprofen, 20-30 parts of glucocorticoid, 5-20 parts of taurine, 5-20 parts of glucose, 5-20 parts of sodium hyaluronate, 5-20 parts of polyvinyl alcohol, 5-20 parts of boric acid and 5-20 parts of a surfactant. The sodium hyaluronate and the polyvinyl alcohol are added into the eye drops, and the sodium hyaluronate is a viscoelastic glycoprotein and has lubricating and anti-inflammatory effects; polyvinyl alcohol is artificial tears and is mainly used for treating eye dryness and foreign body sensation caused by xerophthalmia, the situation that due to long-term use, normal flora imbalance of eyes is caused, the symptom of eye inflammation is aggravated, and the experience feeling of a user is improved is avoided; the taurine and the glucocorticoid are added into the eye drops, and the taurine has the effects of clearing away heat and toxic materials and relieving asthenopia, so that the comfort of the eye drops dropped into eyes is improved.

Use of a bioactive substance for the preparation of an ophthalmic health and / or anti-inflammatory composition, wherein the bioactive substance is a peptide having an amino acid sequence as set forth in SEQ ID NO: 1, wherein the amino acid sequence is a fragment of a bovine skin peptide; wherein the composition is used to reduce the expression level of at least one of an inflammation-related gene comprising a vascular endothelial growth factor A gene, an interleukin-1β gene, and an interleukin-8 gene.

The invention discloses a medicine for treating eye inflammation of caged grey birds and a use method of the medicine. 1 part of lactic acid levofloxacin eye drops and 9 parts of normal saline are prepared; 1 part of lactic acid levofloxacin eye drops and 9 parts of normal saline are mixed, and a mixed solution with the concentration being 10% is prepared. The method is simple, convenient and easy to implement in the aspect of medicine preparation, high in operability and capable of effectively treating infection of eye inflammation of the grey birds. Through long-term observation, after the mixed solution is dripped into the gray bird with eye inflammation, the body health and daily behaviors of the gray bird are not obviously influenced. By means of the method, the number of the gray birds with eye inflammation is effectively reduced, the breeding economic benefits are improved, and meanwhile the breeding risk and cost are reduced.

The application provides a kind of nano preparation with antioxidant function and the use for treating glaucoma, the preparation is composed of oil phase and water phase.Oil phase is lecithin, medium-chain triglyceride, fat-soluble antioxidant, glaucoma treatment drug, water phase is water-soluble antioxidant or deionized water.The nano delivery system described in the application is by loading glaucoma treatment drug in the nano preparation containing antioxidant, can improve local drug concentration, prolong drug retention time, at the same time, through antioxidant scavenging excess active oxygen, reduce inflammatory response, reduce eye cell apoptosis, so as to achieve good therapeutic effect.The nano preparation described in the application can be nano emulsion, liposome, micelle or lipid nanoparticle and other drug delivery systems.The nano preparation can deliver therapeutic drugs while scavenging ROS, reducing eye inflammation and reducing cell apoptosis to achieve more efficient therapeutic effect, with the characteristics of double effect, easy to produce and prepare, wide application range, etc.

The present invention relates to a composition for preventing or treating ocular diseases, comprising Aloe vera gel. Specifically, when orally administered, the Aloe vera (A.vera) gel has been confirmed to have an excellent effect of increasing the expression of genes related to the improvement of tear volume, corneal non-uniformity, eye inflammation, dry eye, corneal thickness, and tear film. Accordingly, the Aloe vera gel can be advantageously used as an active ingredient in an oral composition for the prevention, alleviation, or treatment of ocular diseases, including dry eye syndrome.

The invention relates to the technical field of traditional Chinese medicine eye-protecting eye drops, in particular to a traditional Chinese medicine eye-protecting eye drop formula and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The eye drops are composed of carbomer, glycerin, xanthophyll and 25 traditional Chinese medicine extracts, solubility is improved through a grouping dissolution process, and sterility is guaranteed through three-stage filtration and hot-pressing sterilization. The preparation method comprises the following steps: preparing the carbomer gel matrix, premixing glycerol and xanthophyll, redissolving the traditional Chinese medicine extract, adjusting the pH value of the main liquid medicine to 6.5-7.5, storing in a dark place under nitrogen charging and the like. The pH value of the product is 7.0 + / -0.2, the viscosity is 15-25 mPa.s, the osmotic pressure is 280-320 mOsm / kg, and the stability reaches 24 months. The problems that traditional Chinese medicine eye drops are prone to precipitation, the process is unstable and microbial contamination is caused are solved, and the eye drops are suitable for relieving eyestrain, xerophthalmia and eye inflammation and have the advantages of being natural, mild and small in side effect.

The invention relates to the field of albumin binding type drugs, in particular to a cyclosporin A entrapped albumin binding type drug as well as a preparation method and application thereof. The albumin binding type medicine comprises cyclosporin A or a derivative thereof and albumin, the mass ratio of the cyclosporin A or the derivative thereof to the albumin is 1: (1-10), and albumin molecules are connected through disulfide bonds formed by self-crosslinking of free sulfydryl of the albumin. The albumin combined medicine disclosed by the invention shows a remarkable curative effect in the aspect of treating xerophthalmia, and can be used for remarkably improving tear secretion and quality, effectively repairing corneal injury, relieving eye inflammation and promoting overall recovery of eye tissues. According to the albumin binding type medicine, the retention time of the medicine on the ocular surface can be remarkably prolonged, the local medicine concentration is improved, the eye tissue recovery is comprehensively promoted while symptoms are rapidly relieved, and good safety and potential clinical application value are shown.

The invention discloses an active aldehyde substance inhibitor based on AI design and application thereof. The active aldehyde substance inhibitor comprises a compound shown in a general formula (I) or a derivative thereof, and in the general formula (I), R1 and R2 are independently selected from any one of hydrogen, C2-6 unsaturated alkyl, C1-6 alkoxy, C2-6 halogenated alkyl, halogen, amino, C3-20 cycloalkyl or heterocyclic radical with 4-20 ring atoms; x is carbon or nitrogen; the derivative comprises at least one of a fluorescent marker, a spin marker, a heavy metal marker, an isotope marker and pharmaceutically acceptable salt. The active aldehyde substance (RASP) inhibitor provided by the invention has better capability and speed of complexing aldehyde, and can be quickly and effectively complexed with the active aldehyde substance after being applied to a diseased region, so that the content of RASP in the diseased region is reduced, and further, eye inflammation is reduced or avoided; the eye drops have potential prevention or treatment effects on various eye inflammatory diseases such as xerophthalmia and the like.

The present application relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition containing ox gall, a pharmaceutical preparation and application, the present application provides a traditional Chinese medicine composition containing ox gall, which has the effects of clearing heat and resolving toxins, cooling liver and resolving lung, dispersing wind and relieving pain, and the preparation has a wide range of uses, the preparation method of the composition provided by the present application is easy to operate, and through years of production practice accumulation, the quality of the obtained product is stable and controllable, and the product is used for preparing drugs for treating liver and lung heat accumulation, wind and fire disturbance, dizziness, oral and nasal sores, wind and fire toothache, sudden eye inflammation, skin itching and other diseases in clinic, and has a wide application value.

The invention relates to the use of an 11β-HSD1 pathway activity inhibitor in the preparation of a drug for treating glaucomatous cyclitis syndrome. By specifically inhibiting 11β-HSD1 activity in the eye, the drug can effectively correct the imbalance of local corticosteroid metabolism in the eye, alleviate the physiological effects of excess mineralocorticoids, and simultaneously reduce aqueous humor production and alleviate eye inflammation. The drug is suitable for treating glaucomatous cyclitis syndrome and other diseases related to increased 11β-HSD1 activity in the eye. The invention has the advantages of novel targets, high efficiency and safety, and long-term intraocular pressure reduction, and has important clinical application value.

The invention belongs to the technical field of eye drops, and particularly relates to pure traditional Chinese medicine eye drops prepared by an ancient method for treating eye inflammation and a preparation method. The eyedrops are prepared from the following components: 10 to 40 parts of honeysuckle flower, 5 to 30 parts of flos eriocauli, 8 to 20 parts of flos buddlejae, 8 to 16 parts of spica prunellae, 5 to 14 parts of herba equiseti hiemalis and 1 to 5 parts of menthol. An ancient-method processing technology and a mechanochemical method extraction technology are combined, the ancient-method processing is used for directionally enhancing release of effective components through targeted activation of channel tropism attributes of medicinal materials, and the mechanochemical method utilizes high-energy ball milling and chemical reaction to accurately destroy a plant cell wall structure and remarkably improve the dissolution efficiency of medicinal material components; the medicine effect is obviously improved.

The invention belongs to the technical field of ophthalmology medical equipment, and particularly relates to a wet chamber mirror suitable for thyroid-related eye diseases, which comprises a wet chamber mirror body, a storage box is fixedly installed on one face of the wet room mirror body, a micro water pump is fixedly installed in the storage box, a connecting pipe is fixedly installed at the output end of the micro water pump, two liquid outlet pipes are fixedly installed at the end, away from the micro water pump, of the connecting pipe, and a liquid inlet pipe with a one-way valve is fixedly installed on one face of the storage box. A weight box is fixedly installed on the face, away from the storage box, of the room wetting mirror body. A micro water pump in the storage box is started through a control button, so that the water pump conveys purified water in the storage box into the corresponding fixing frames through a connecting pipe and two liquid outlet pipes respectively, and the purified water is sprayed to eyes of a patient through liquid outlet holes of the fixing frames, so that discomfort such as dryness of the eyes of the patient is relieved, aggravation of eye inflammation of the patient is effectively avoided, and the patient's eye quality is improved. And the vicious circle is avoided.

A process of manufacturing sterile topical ophthalmic aqueous nanosuspensions of nanocrystals of fluticasone propionate Form A. The sterile topical ophthalmic nanosuspensions may be used in the treatment of eye inflammation conditions such as blepharitis, posterior blepharitis, Meibomian gland dysfunction and dry eye through topical administration of said nanosuspensions to eyelids, eyelashes and eyelid margin.

The invention provides a wet fog therapeutic apparatus for treating eye inflammation, and belongs to the technical field of wet fog therapeutic apparatuses. Comprising an atomizer and an eyeshade, a conveying pipe is fixedly connected to the atomizer, the eyeshade is composed of two independent eyeshade bodies, connecting pipes are fixedly connected to the two eyeshade bodies, the connecting pipes and the conveying pipe are connected together through a three-way valve, and a rubber ring is fixedly connected to the edge of the eyeshade. The drainage assembly is used for draining the liquid medicine in the eyeshade and on the face of the patient, and the drainage assembly is connected with the eyeshade. By arranging the drainage assembly, water accumulated in the eyeshade can be well drained, and water in the eyeshade and on the skin surface of a patient can be drained in a targeted mode according to the sitting posture and the lying posture of the patient.

The invention belongs to the technical field of contact lenses, and particularly discloses a fragrant UV (ultraviolet) photocuring contact lens material as well as a preparation method and application thereof. The contact lens material disclosed by the invention is prepared from 30 to 40 parts of a siloxane monomer, 50 to 80 parts of a hydrophilic monomer, 0.01 to 0.1 part of a nanocapsule, 0.5 to 1.5 parts of a cross-linking agent, 0.2 to 0.8 part of an ultraviolet light absorber and 0.5 to 1.5 parts of an initiator. Wherein the core material of the nano capsule is prepared from alpha-bisabolol, vanillin and apigenin. By adding the active components, xerophthalmia, eye inflammation and eye dryness can be relieved, and many problems caused by wearing contact lenses are avoided to a certain extent; the invention further discloses application of the nanocapsule, slow release of effective components is achieved, and stimulation to eyes is avoided. In addition, the mask also has the effects of emitting fragrance for a long time and making a wearer have physical and mental pleasure.