A colorimetric probe for identifying iron ions and its preparation and application

A technology of colorimetric probes and iron ions, which is applied in the field of dual-functional probes for identifying iron ions and fluorine ions, can solve problems such as low yield, cumbersome synthesis steps or purification steps, complex molecular structures of probes, etc., and achieve optical The effect of stable performance, high selectivity, and simple synthesis steps

Active Publication Date: 2021-09-28
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these probe molecules generally have disadvantages such as complex structures, cumbersome synthesis steps or purification steps, and low yields, which limit their applications.

Method used

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  • A colorimetric probe for identifying iron ions and its preparation and application
  • A colorimetric probe for identifying iron ions and its preparation and application
  • A colorimetric probe for identifying iron ions and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: the preparation of colorimetric probe

[0037] Add 0.204g of 3-acetyl-4-hydroxy-coumarin and 0.109g of o-aminophenol into a two-neck round bottom flask, dissolve in 60mL of methanol solution, stir and heat to reflux for 6h. After the reaction is cooled, a solid is precipitated, filtered under reduced pressure, rinsed with absolute ethanol three times, and filtered under reduced pressure to obtain the pure product. The product is a light yellow solid. After vacuum drying, 4-hydroxy-3-[1- (2-Hydroxyphenylimino)-ethyl]-chromen-2-one, yield 92.3%. NMR characterization is as follows: 1 H NMR (400MHz, CDCl 3 )δ,8.07(m,1H),7.60(m,1H),7.32(m,2H),7.10(s,1H),7.01(s,1H),7.18(d,J=8.0Hz,2H), 7.04(d,J=8.0Hz,2H),2.68(s,3H).IR:3147cm -1 (O-H),1670cm -1 (C=O),1459cm -1 (C=N).m.p.181.6-182.8°C.

Embodiment 2

[0038] Embodiment 2: the investigation of the colorimetric probe of the present invention to the iron ion recognition ability

[0039] The probe molecule (prepared in Example 1) was formulated into 2×10 -5 M in DMF solution, and then add 10equiv of various metal ions Fe 3+ , Hg 2+ , Al 3+ , Mn 2+ , Mg 2+ , Zn 2+, Measure the UV-Vis absorption spectra of the blank solution and the mixed solution. It was found experimentally that only by adding Fe 3+ , the original probe molecule's maximum absorption peak at 326nm had a significant blue shift to 296nm (Δλ=30nm), and the maximum absorption intensity also increased from 0.31 to 0.80 (2.6 times). While other metal ions did not change significantly ( figure 1 ). It shows that the probe molecule of the present invention can specifically and selectively recognize iron ions.

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Abstract

The invention discloses a colorimetric probe for identifying iron ions and its preparation and application. The colorimetric probe has a structure shown in formula I: the colorimetric probe of the invention is prepared by one-step synthesis, and the synthesis conditions The method is simple, easy to purify and high in yield; the prepared colorimetric probe has a strong ability to identify iron ions and a fast response speed, and has practical application value in the fields of biochemistry, environmental science and the like.

Description

technical field [0001] The invention relates to the technical field of ion detection, in particular to a bifunctional probe for identifying iron ions and fluorine ions and its preparation and application. Background technique [0002] Iron ions are indispensable substances in many physiological processes of human beings. It is the core part of hemoglobin, participates in the synthesis of hemoglobin, myoglobin, cytochrome, cytochrome oxidase, peroxidase and catalase in the process of oxygen transfer, and plays an important role in metabolic activities; however, After water or food is contaminated by iron ions, if the content is too high after drinking or eating and entering the human body, it will cause great damage to the heart, liver, and pancreas, and even cause life-threatening in severe cases. Therefore, whether it is the lack of iron or excessive intake will cause the disorder of the life system, the detection of iron ions is widely concerned by the medical and biochem...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/78G01N21/33
Inventor 刘志莲张书香冯子琦杨震牟佳伟王兆萱于诗雨
Owner UNIV OF JINAN
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