Oral skin regeneration promoting oil for treating oral cavity burn and scald and preparation method and application thereof

A technology for skin-regenerating oil, burns and scalds, which is applied in the directions of medical preparations, pharmaceutical formulas, and plant raw materials containing active ingredients.

Inactive Publication Date: 2019-06-28
深圳市本源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, there is currently no drug that can protect the wound and has a therapeutic effect. Therefore, it is necessary to find a safe and effective drug for this indication.

Method used

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  • Oral skin regeneration promoting oil for treating oral cavity burn and scald and preparation method and application thereof
  • Oral skin regeneration promoting oil for treating oral cavity burn and scald and preparation method and application thereof
  • Oral skin regeneration promoting oil for treating oral cavity burn and scald and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: a kind of preparation method of the oral skin-reinforcing oil for the treatment of oral cavity burns and scalds, its steps are as follows:

[0040] Put 1000g of sesame oil into a container, then add 30g each of dry powders of Scutellaria baicalensis, rhubarb, coptis, and Phellodendron phellodendri, 10g each of dry powders of astragalus, angelica, burnet, rehmannia glutinosa, angelica dahurica, Baiwei, and bletilla striata, and stir evenly; let stand and soak After 10 days, stir and heat, keep stirring at an oil temperature of 55°C for 2 hours, then stop heating, filter to remove slag, add 10g of frankincense and myrrh dry powder to it, stir and heat at 55°C for 30 minutes, stop heating , filter to remove slag, when the oil temperature drops to 40°C, add borneol 3g and 500g coconut oil to it, stir well, wait to cool to room temperature, get oral skin tonic oil 1, airtight storage after bottling.

Embodiment 2

[0041] Embodiment 2: a kind of preparation method of oral skin-skin oil for the treatment of oral cavity burns and scalds, its steps are as follows:

[0042] Put 800g of sesame oil into a container, then add 30g each of dry powders of Astragalus, Angelica, Burnet, Dihuang, Angelica, Baiwei, and Bletilla striata, and 10g of dry powders of Scutellaria baicalensis, rhubarb, Coptis chinensis, and Cortex Phellodendri, stir well; let stand and soak After 3 days, stir and heat, keep stirring at an oil temperature of 65°C for 1 hour, then stop heating, filter to remove slag, add 10 g of frankincense and myrrh dry powder to it, stir and heat at 65°C for 5 minutes, stop Heating, filtering to remove slag, when the oil temperature drops to 30°C, add 8 g of borneol and 200 g of coconut oil to it, stir well, and wait until cooled to room temperature to obtain Oral Skin Tonic Oil 2, which is bottled and stored in an airtight manner.

Embodiment 3

[0043] Example 3: Effect of Oral Shengfu Oil on Histological Structure of Mice Tongue Scald Caused by Boiling Water

[0044] The experimental animals were SPF grade Kunming male young (5-week-old) mice (provided by the Hubei Provincial Center for Disease Control and Prevention). Drink water and eat freely, keep the room temperature at 25±1°C, and the light-dark cycle is 12 hours.

[0045] 1. Modeling and administration of oral boiled water burns

[0046] Mice are equally divided into 5 groups, 5 in every group, and implement numbering record: blank group, model group, Shengpi oil group (oral Shengpi oil 1 prepared in embodiment 1), sesame oil (solvent of Shengpi oil- sesame oil) group, dexamethasone group. All mice were orally given 300 μl of local anesthetic lidocaine hydrochloride (0.02 g / mL), and then except the blank group orally given 500 μl of normal saline, the mice in other groups were orally given 500 μl of 100°C boiling water, Simulate human body burns, resulting ...

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an oral skin regeneration promoting oil for treating oral cavity burn and scald and a preparation method and application thereof. The oral skin regeneration promoting oil is prepared from, by weight, 10-30 parts of scutellaria baicalensis, 10-30 parts of coptis chinensis, 10-30 parts of amurcork tree bark, 10-30 parts of Chinese rhubarb, 10-30 parts of astragali radix, 10-30 parts of angelica sinensis, 10-30 parts of garden burnet, 10-30 parts of rehmannia glutinosa, 10-30 parts of angelica dahurica,10-30 parts of blackend swallowwort root, 10-30 parts of bletilla striata, 10-30 parts of frankincense, 10-30 parts of myrrh, 3-8 parts of borneol and 1000-1500 parts of edible vegetableoil, wherein the skin regeneration promoting oil is prepared by heating and mixing the materials in batches. Staining results show that the inflammatory cell infiltration of wound tissues of oral cavity burn and scald site of a rat group using the skin regeneration promoting oil is obviously reduced, the tissue structure is relatively complete, the skin regeneration promoting oil has the effectsof treating oral cavity burn and scald caused by boiling water, acid and alkali. The oral toxicity experiment of the skin regeneration promoting oil show that there is no significant difference in body weight, liver and kidney function of rats compared with a blank group, and no obvious influence is produced.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an oral skin-reinforcing oil for treating oral burns and scalds, a preparation method and application thereof. Background technique [0002] "Eat food while it's hot" has always been a tradition on the dinner table. People have always had the awareness that low temperature will affect the taste of food and often eating cold food will hurt the stomach. Therefore, people have gradually formed the habit of "eating while it is hot". . In daily life, people are often used to eating boiled water, boiling hot, freshly cooked dumplings, etc. Studies have shown that if the temperature of food entering the mouth exceeds 65 degrees, it will cause serious burns to the mouth. During eating, the oral cavity is the first organ to come into contact with a heat source. Because food needs to be chewed in the mouth, overheated food needs to stay in the mouth. At...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/10A61P1/02A61K31/045
Inventor 唐和斌唐东杰洪静
Owner 深圳市本源生物科技有限公司
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