Copper nanoclusters, thymine-modified hyaluronic acid, polycopper nanoclusters and preparation method and application of copper nanoclusters, thymine-modified hyaluronic acid and polycopper nanoclusters

A technology of thymine and hyaluronic acid, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as no indication of the formation of copper clusters
CN109939243AActive Publication Date: 2019-06-28武汉广行科学研究有限公司
10 Cites 6 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
武汉广行科学研究有限公司
Publication Date
2019-06-28

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides copper nanoclusters (CuNCs), thymine-modified hyaluronic acid (TMHA), polycopper nanoclusters (PCuNCs) and a preparation method and application of CuNCs, TMHA and PCuNCs in detection, diagnosis and treatment; for example, Parkinson's disease is detected, diagnosed and treated. The TMHA is represented by formula I, wherein the degree of substitution of thymine in HA is in therange of 1-50%, and n representing the repeating number of GlcA-GlcNAc repeats is an integer from 10 to 10,000.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention generally relates to the field of nanomedicine technology, and more specifically relates to copper clusters (CuNCs), thymine-modified hyaluronic acid (TMHA) and polycopper clusters (PCuNCs), as well as preparation methods and their use in detection , diagnosis and treatment; eg Parkinson's disease. Background technique

[0002] Neurodegenerative diseases are one of the major threats to human health. Their common pathological features are abnormal tangles of proteins in nerve cells and amyloidosis, as well as related neuronal apoptosis and nerve damage. Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by tremors, muscle stiffness, bradykinesia, postural instability and movement disturbances. PD mainly occurs in the elderly, and the incidence rate increases with age. According to conservative estimates, the number of PD patients in the world has exceeded 10 million. However, the etiolog...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More