Application of oxalomalic acid in preparation of medicine for treating nerve cell injury
A technology of oxalyl apple and medicine, which is applied in the field of biomedicine, can solve the problems of oxalyl malic acid and other problems, reduce cerebral ischemic infarct volume and neurobiological score, reduce neurobiological score, and have little irritation Effect
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[0024] Animal experiment: the protective effect of oxalomalic acid on ischemic stroke
[0025] Implemented drugs: oxalyl malic acid was purchased from a reagent company.
[0026] Dissolve oxalomalic acid in saline.
[0027] Experimental animals: healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then the administration group was orally administered according to the requirements of the experiment.
[0028] Modeling method: The rat model of cerebral ischemia / reperfusion injury was prepared by the middle cerebral artery occlusion (MCAO) method. The steps are as follows: (1) Separate the external carotid artery (CCA), and separate the left external carotid artery (ECA) and internal carotid artery (ICA) upward; (2) Temporarily clamp the ECA and ICA with ophthalmic forceps, and ligate ...
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