5 results about "Oxalomalic acid" patented technology

The application belongs to the technical field of compound preparation, and particularly relates to a preparation method of an alkali metal salt of an oxalate chelate structure, at least comprising the following steps: mixing tris(trimethylsilyl) phosphate, an oxalate and a phosphorus-containing or boron-containing fluorine compound in a first organic solvent, stirring and heating to obtain lithium phosphate, trimethyl fluorosilane gas, and difluorobisoxalate phosphate or difluorooxalate borate, filtering the reaction solution to obtain lithium phosphate solid and a difluorobisoxalate phosphate solution or a difluorooxalate borate solution; adding a second organic solvent for recrystallization after concentration; and obtaining difluorobisoxalate phosphate or difluorooxalate borate solid after filtration, and drying the solid under reduced pressure to obtain a finished product. The process is simple, and the cost is low. By-products lithium phosphate, potassium fluoride and hexamethyldisiloxane can be directly sold as products after purification. Therefore, the application has an atomic utilization rate close to 100%, no invalid waste, less three-waste emissions, and is friendly to the environment.

This disclosure provides a process for preparing α-hydroxy esters by adding a vinyl Grignard reagent to an oxalate ester and then thiolated the resulting double bond. It also provides α-hydroxy esters and synthetic intermediates prepared according to the process disclosed herein, as well as compositions comprising said α-hydroxy esters.

The present invention refers to recombinant forms of Glutamate-oxaloacetate transaminase (GOT1) fused to a Fc region to induce a neuroprotective effect in a mammal in need thereof. The chimeric protein originated with this fusion presents an improved pharmacokinetic profile while keeping similar specific activities when compared with the standard GOT enzyme. This enhanced stability of the protein in plasma is essential for the neuroprotective role of GOT on ischemic stroke events and other pathologies.

The application discloses a synthesis method of indole-2-carboxylic acid, which is suitable for industrial production and comprises the following steps: (1) condensation: mixing o-nitrotoluene, diethyl oxalate and sodium ethoxide ethanol solution, raising to 75-85 DEG C and reacting for 1.5-3 hours, adding into water, stirring for 0.5-1.5 hours, removing ethanol, decoloring, filtering, adjusting the pH of the filtrate to 1-2, and obtaining an intermediate; (2) reduction: adding methanol to the intermediate, adding Raney nickel, raising to 55-65 DEG C, adding hydrogen and reacting, lowering to room temperature, filtering, removing methanol, lowering to 0-5 DEG C and preserving for 1-2 hours, and filtering to obtain a crude product; and (3) purification: adding water to the crude product, adjusting the pH to 8-9, decoloring, filtering, adjusting the pH to 2-3, precipitating a solid, filtering, and drying the filter cake.

The invention relates to a process for the production of an oxalate polyester (co)polymer, comprising the use of bis(2-methoxyphenyl) oxalate to introduce oxalate monomer units into the polymer chain, comprising at least steps (a) and (b):(a) an esterification / transesterification step wherein at least one dicarboxylic acid or an ester derivative thereof is / are reacted with an excess of at least one diol compound to form a pre-polycondensation product comprising alcohol end groups, or otherwise producing such pre-polycondensation product;(b) a polymerization step comprising polycondensation of the product of step (a) with bis(2-methoxyphenyl) oxalate in a molar amount that is equal to between about 0.4 to about 0.6 equivalents of the molar amount of alcohol end groups in the pre-polycondensation product of step (a).The process is an efficient process for the production of novel and existing oxalate polyester (co)polymers, also with high molecular weight, and optionally without the need for the addition of a metal catalyst.