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Application of commercially available yoghourt in preventing urinary calculus

A technology for urolithiasis and yogurt, which is applied in the application field of yogurt in preventing urolithiasis, can solve the problems of difficulty in achieving effect, low compliance, and long-term use by patients.

Inactive Publication Date: 2009-07-22
上海交通大学医学院附属第三人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the preventive method cannot be done once and for all, it must be easy for patients to use it for a long time. Otherwise, no matter how good the effect is, it is only short-term and cannot achieve the purpose of long-term prevention.
Although the preventive effect of taking live bacterial preparations is good, patients need to deliberately insist on taking them, so the compliance rate is not high
Although many dairy products contain lactic acid bacteria, the amount of bacteria is usually 10 4 ~10 6 CFU / g, it is still difficult to achieve a satisfactory effect

Method used

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  • Application of commercially available yoghourt in preventing urinary calculus
  • Application of commercially available yoghourt in preventing urinary calculus
  • Application of commercially available yoghourt in preventing urinary calculus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1. Identification of lactic acid bacteria in yogurt, drug susceptibility test and determination of bacterial content

[0030] Objective: To determine the content and types of lactic acid bacteria contained in six brands of yogurt in Shanghai market, and to determine their sensitivity to antibiotics. Materials and methods

[0031] 1. Materials

[0032] (1) Main experimental equipment: sterilized glass plate petri dish, weighing balance, 5% CO 2 Incubator (Forma, 3111 type), autoclave (Shanghai Boxun Industrial Co., Ltd.), turbidity measuring instrument (DENSIMAT, Meli Ai Company), automatic microbial identification instrument (ATB 8.22, Meli Ai Company).

[0033] (2) Experimental reagents:

[0034] 1. Peptone, yeast extract, anhydrous sodium acetate, etc.: (analytical pure Shanghai Chemical Reagent Company)

[0035] 2. Anaerobic bacteria identification plate and liquid medium (API 50CH medium): (Meiliai Company)

[0036] 3. Drug sensitivity identification test...

Embodiment 2

[0065] Example 2 Determination of the ability of three kinds of lactic acid bacteria to decompose oxalic acid in vitro

[0066] Objective: To determine the oxalic acid decomposition ability and oxalic acid resistance growth ability of Lactobacillus bulgaricus, Lactobacillus acidophilus, Streptococcus thermophilus and mixed bacteria in liquid medium.

[0067] Materials and methods

[0068] 1. Materials

[0069] (1) Experimental equipment:

[0070] 1. Sterilize the plate, 5% CO 2 Incubator, autoclave, weighing balance, electric stove, Erlenmeyer flask, graduated cylinder, straw.

[0071] 2.721 Spectrophotometer (Xiamen Analytical Instrument Factory)

[0072] (2) Experimental reagents:

[0073] 1. Dried and frozen pure strains of Lactobacillus bulgaricus, Lactobacillus acidophilus, Streptococcus thermophilus:

[0074] (Chinese Academy of Sciences Culture Collection Center)

[0075] 2. Yogurt: brand-name yogurt in plastic cans on the second day...

Embodiment 3

[0139] Example 3 Effects of drinking yogurt on urinary oxalate excretion and intestinal lactic acid bacteria in normal diet rats

[0140] Objective: To understand the effect of drinking yogurt on the amount of urinary oxalate excretion and intestinal lactic acid bacteria in rats, and to understand the correlation between the amount of intestinal lactic acid bacteria and urinary oxalic acid excretion in rats.

[0141] Method: Three groups of rats were continuously fed with yoghurt, sterilized yoghurt and normal saline for 20 days, 4ml / d, urine oxalate excretion was measured every 4 days, and the number of lactic acid bacteria in the intestinal tract was measured every 7 days. Rat body weight changes. Urinary oxalate excretion, the number of lactic acid bacteria in the intestinal tract, and the body weight of the rats were measured on the 7th and 14th days after irrigation was stopped.

[0142] Materials and methods

[0143] 1. Materials:

[0144] Experimental animals: 30 hea...

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Abstract

The invention relates to application of yoghourt in the field of preventing urinary calculus. Lactobacillus in the yoghourt has the effect of resolving oxalic acid, can degrade food-borne oxalic acid in intestinal tract, and reduce absorptive amount of the intestinal tract to the oxalic acid, so the yoghourt has the efficacy of preventing urinary calculus of the oxalic acid; and the yoghourt has important application in the fields of medicines, foods and health products. Through animal experiments, the invention provides that urinary oxalate excretion can be effectively reduced by drinking commercial yoghourt, thereby exploring a practical approach in preventing relapse of oxalate calcium calculus. The yoghourt has a plurality of obvious characteristics in health-care function and medicine-food homologization, and has the advantages of low cost, convenient taking and high compliance degree compared with a patient taking drugs, and does not have any side effect, so the yoghourt has better potential of prevention use.

Description

technical field [0001] The invention relates to a food for preventing urolithiasis, in particular to the application of yogurt in preventing urolithiasis. Background technique [0002] Urolithiasis is a common disease of the urinary system, calcium oxalate stones account for 70% to 80%, and its recurrence rate is relatively high. Therefore, prevention has always been an important research topic. In the formation of calcium oxalate stones, the role of oxalic acid is much greater than that of calcium, and the absorption of oxalic acid in the intestine is an important factor affecting the change of urinary oxalate excretion. If a simple method can be found to effectively reduce the absorption of oxalic acid in the intestinal tract, the prevention of calcium oxalate stones will become possible. [0003] The oxalobacillus living in the intestinal tract has the ability to decompose oxalic acid, but there is currently no live bacterial preparation for oral supplementation. In rec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/123A23L1/29
Inventor 张士青顾欣
Owner 上海交通大学医学院附属第三人民医院
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