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Application of oxalomalic acid in preparation of drugs to treat nerve cell damage

A nerve cell injury and oxalyl apple technology, applied in the field of biomedicine, can solve problems such as oxalyl malic acid not seen, and achieve the effects of reducing brain nerve cell death, enhancing compliance, and inhibiting nerve cell necroptosis

Active Publication Date: 2019-07-05
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Nec-1 is only used as a tool drug in animal experiments. At present, there is no clinical drug targeting RIPK1 / RIPK3 / MLKL for the treatment of ischemic stroke, and there is no oxalylmalic acid treatment for ischemic stroke or neuropathy. Reports in Cellular Injury

Method used

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  • Application of oxalomalic acid in preparation of drugs to treat nerve cell damage
  • Application of oxalomalic acid in preparation of drugs to treat nerve cell damage
  • Application of oxalomalic acid in preparation of drugs to treat nerve cell damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] Animal experiment: the protective effect of oxalomalic acid on ischemic stroke

[0025] Implemented drugs: oxalyl malic acid was purchased from a reagent company.

[0026] Dissolve oxalomalic acid in saline.

[0027] Experimental animals: healthy male SD rats with a body weight of 250-300 g. The experimental animals were fed for one week in an environment with a temperature of 25° C., a relative humidity of 60%, free access to drinking water, and regular and quantitative amounts, and then the administration group was orally administered according to the requirements of the experiment.

[0028] Modeling method: The rat model of cerebral ischemia / reperfusion injury was prepared by the middle cerebral artery occlusion (MCAO) method. The steps are as follows: (1) Separate the external carotid artery (CCA), and separate the left external carotid artery (ECA) and internal carotid artery (ICA) upward; (2) Temporarily clamp the ECA and ICA with ophthalmic forceps, and ligate ...

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Abstract

The invention relates to application of oxalomalic acid in the preparation of drugs to treat nerve cell injury. When applied to the treatment of ischemia reperfusion injury, in particular to the treatment of brain tissue neuropathy, more in particular to the protection of ischemic stroke, the oxalomalic acid can evidently relieve cerebral ischemia / reperfusion injury, alleviate cranial nerve cell injury, and improve nerve cell functionality.

Description

technical field [0001] The invention relates to the application of oxalylmalic acid in the preparation of medicines for treating nerve cell damage, and belongs to the field of biomedicine. Background technique [0002] Ischemic stroke is a common and frequently-occurring disease that seriously endangers human health. It has become the first cause of disability and the third cause of death in the world. The incidence of ischemic stroke accounts for about 70-80% of cerebrovascular diseases. [0003] Cerebral ischemic injury is related to multiple mechanisms such as excessive formation of free radicals, excitatory amino acid toxicity, intracellular calcium overload, and inflammatory response. Regardless of the mechanism, the final outcome will lead to neuronal cell death, functional destruction, and cerebral infarction form. There are two main ways of cell death: necrosis and apoptosis. The traditional view is that necrosis is a random, unexpected and unregulated passive deat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/194A61P25/00A61P9/10A61P25/28A61P25/16A61P25/14A61P31/12A61P3/10
CPCA61K31/194A61P3/10A61P9/10A61P25/00A61P25/14A61P25/16A61P25/28A61P31/12
Inventor 彭军罗秀菊刘为宁李悦琪任凯迪田静彭靖杰刘斌付四海
Owner CENT SOUTH UNIV
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