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Phantom suitable for CT standard value detection, preparation method and application thereof

A phantom and raw material technology, applied in the field of CT phantom, can solve problems such as uneven dissolution of calcium carbonate powder, and achieve the effect of reducing insoluble particles and uneven density

Active Publication Date: 2019-07-30
TAISHAN MEDICAL UNIV
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  • Claims
  • Application Information

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Problems solved by technology

In addition, the inventor provides a better preparation method for the problem of uneven dissolution of calcium carbonate powder in agarose gel

Method used

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  • Phantom suitable for CT standard value detection, preparation method and application thereof
  • Phantom suitable for CT standard value detection, preparation method and application thereof
  • Phantom suitable for CT standard value detection, preparation method and application thereof

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preparation example Construction

[0045] The fourth aspect of the present disclosure provides a preparation method of the CT phantom described in the third aspect, the preparation method comprising the following steps:

[0046] (1) Obtain the average CT value and three-dimensional contour of the object to be simulated by reading the original DICOM image;

[0047] (2) Calculate the consumption of raw materials according to the CT value of the simulated object described in step (1);

[0048] (3) Mixing and heating the weighed amount of raw materials to completely dissolve them, adding the dissolved solution into a mold, and the mold is made according to the three-dimensional contour described in step (1).

[0049] In some embodiments, the specific operation of mixing and heating the raw materials in the above step (3) is as follows: mix the weighed agarose, sodium chloride, magnesium chloride, calcium phosphate and calcium carbonate and grind them in a mortar. At the same time, add a small amount of water sever...

Embodiment 1

[0055] In this example, 1.5% agarose, 2% calcium-containing inorganic salt, 0.95% NaCl, 0.02% MgCl 2 , 0.2mmol / L gadopentetate meglumine, and distilled water as the matrix to make test samples to investigate the influence of different ingredients and preparation methods on the phantom.

[0056] Experimental group 1: 1.5% agarose, 2% calcium-containing inorganic salt (calcium carbonate: calcium phosphate = 2.5:1), 0.95% NaCl, 0.02% MgCl 2 , the gadopentetate meglumine of 0.2mmol / L, and the balance is distilled water.

[0057] Experimental group two: 1.5% agarose, 2% calcium carbonate, 0.95% NaCl, 0.02% MgCl 2 , the gadopentetate meglumine of 0.2mmol / L, and the balance is distilled water.

[0058] Experimental group 3: 1.5% agarose, 2% calcium-containing inorganic salt (calcium carbonate:calcium phosphate=2.5:1), 0.97% NaCl, 0.2 mmol / L gadopentetate meglumine, and distilled water as the balance.

[0059] Add the above three groups of weighed raw materials into water and prepa...

Embodiment 2

[0066] In this example, with 1.5% agarose, 0.95% NaCl, 0.02% MgCl 2 , 0.2mmol / L gadopentetate meglumine, distilled water as the matrix to make test samples, by changing the proportion of calcium-containing inorganic salts, to make phantoms with different CT values. In the calcium-containing inorganic salt used in this embodiment, the doping ratio of calcium carbonate and calcium phosphate is 2.5:1.

[0067] CT scanning: use CT equipment to scan the prepared multiple samples, and obtain the corresponding CT value of each sample.

[0068] The experimental data in Table 1 shows that as the percentage of calcium-containing inorganic salt increases, the CT value of the material shows a good linear change. Through data fitting, a linear equation is obtained: y=30.612*x+10.015, correlation coefficient R 2 =0.9897, such as figure 1 shown.

[0069] Table 1 The CT values ​​obtained by detecting different calcium-containing inorganic salt percentages

[0070]

[0071]

[0072]...

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Abstract

The invention belongs to the technical field of CT phantoms, and particularly relates to a phantom material suitable for CT standard value detection, a preparation method and application thereof. Withthe rapid development of medical imaging technology, the demand for customization and individualization in radiation therapy field becoms more and more obvious. The processing technology and means ofrapid design and manufacturing of phantoms are beneficial to manufacturing more flexible phantom products with individual adaptability. The invention provides a composition for preparing a phantom, which comprises agarose, calcium-containing inorganic salt, sodium chloride, magnesium chloride and a magnetic resonance contrast agent, and continuous change of CT values can be achieved by adjustingthe proportion of the calcium-containing inorganic salt in the raw material. In addition, the composition also has better dissolution effect in the process of preparing the phantom and can effectivelyshorten the preparation time of the phantom, the prepared phantom has more uniform density, has CT values and a relaxation time which are closer to viscera and muscles under certain proportions, andcan adapt to the detection of both CT and MRI.

Description

technical field [0001] The disclosure belongs to the technical field of CT phantom, and in particular relates to a phantom material, preparation method and application suitable for CT standard value detection. Background technique [0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art. [0003] The quality control (Quality Control, QC) of medical imaging and radiation physics is an important task to ensure that medical images meet the standards of diagnosis and treatment, and to ensure medical and radiation safety. As an important quality control tool for medical imaging and radiation physiotherapy, the phantom is usually used as a standard device, which can be used to simulate the actual human body or sig...

Claims

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Application Information

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IPC IPC(8): A61B6/00
CPCA61B6/583
Inventor 邱建峰贺瑶瑶侯坤石丽婷赵慧慧李正美
Owner TAISHAN MEDICAL UNIV
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