Water-soluble seaweed activated calcium-chitosan oligosaccharide-polypeptide hydrogel and preparation method thereof

Abstract

The invention discloses water-soluble seaweed activated calcium-chitosan oligosaccharide-polypeptide hydrogel and a preparation method thereof. The water-soluble seaweed activated calcium-chitosan oligosaccharide-polypeptide hydrogel disclosed by the invention can be used for wound healing and scar fading in the fields of medical treatment and beauty. Liquid is smeared or sprayed on a wound or a scar when the hydrogel is in use, and a crosslinking film of seaweed bio-calcium-chitosan oligosaccharide-polypeptide is formed on the surface after solvent evaporates within seconds. The film has theeffects of efficiently absorbing tissue fluid, promoting cell repair, and preventing bacterial invasion, and has the advantages that the film has good water resistance and air permeability, does not need to be torn off after use, has a coverage area with changeable size, is not greasy after being smeared on an affected part, and does not affect activities, and the like.

Description

technical field [0001] The invention relates to a water-soluble seaweed active calcium-chitooligosaccharide-polypeptide hydrogel and a preparation method thereof, belonging to the field of biomedical materials / beauty. Background technique [0002] The wound healing process usually requires covering the wound with a medical dressing to absorb wound exudate, prevent bacterial invasion and keep the wound moist. With the development of medical technology, many drug carriers with excellent biocompatibility are widely used in wound healing. Calcium alginate fiber is one of the most advanced biomedical dressings. Calcium alginate fiber accessories can absorb exudate equivalent to 10-20 times its own weight. After contacting with wound exudate, calcium alginate dressing will form a soft hydrogel to cover the wound through sodium-calcium ion exchange to prevent wound surface Adhesive to tissue, easy to remove. And provide an ideal moist environment for wound healing, improve the r...

AI Technical Summary

Problems solved by technology

The disadvantage is that the use of freeze-drying production process consumes time and electricity, is not conducive to cost control, and has great environmental pollution, and the final product is solid, which is not convenient to use and simple enough to operate; the prepared chitosan, collagen and calcium alginate The calcium alginate in the composite sponge biological dressing has a large molecular weight and is insoluble in water, so it takes a long time to combine with the wound exudate, the utilization efficiency is low, the scar desalination function is small, it cannot form a breathable film on the wound, and it is not waterproof and dustproof