A sensor

A technology of sensors and sensing elements, applied in the direction of sensors, instruments, scientific instruments, etc., can solve the problem of not being able to provide real-time data

Inactive Publication Date: 2019-08-09
AGENCY FOR SCI TECH & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These devices cannot determine the health of the wearer at the molecular level, nor can they provide real-time data
Additionally, these technologies utilize expensive materials for sensing, such as humidity sensors, printed circuit boards, and photoresistors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Development of Sodium Selective Polymer Sensing Element

[0095] The following describes 1 mL of Na + Preparation of selective membranes, which can be scaled up according to the required volume. 241.5 μL of tetrahydrofuran (THF) with 100 μL of sodium ionophore X (15 g / L in THF), 50 μL of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (Na-TFPB, in 16 g / L in THF), 500 μL of PVC (100 g / L in THF) and 108.5 μL of bis(2-ethylhexyl) sebacate (pure DOS) were mixed. The solution was mixed well, drop cast onto the surface of the copper tape, and allowed to dry at ambient conditions for at least 1 hour. The modified copper strip was then used as a working electrode for detecting Na+ in the sample solution.

[0096] To prepare a reference electrode for Na+ measurements, another piece of copper tape was coated with Ag / AgCl ink. The coated copper strips were then dried at 120°C for 1 hour.

Embodiment 2

[0098] Preparation of MIP membranes for urea sensors

[0099] To fabricate the working electrode, a 10 wt% solution of poly(vinyl alcohol-co-ethylene) (10% EVAL) was first prepared in dimethyl sulfoxide (DMSO). Next, template urea molecules were dissolved in the prepared 10% EVAL solution so that urea had a final concentration of 2 wt%. The mixture was then drop cast onto copper tape and allowed to dry overnight at ambient conditions.

[0100] For the reference electrode, 1 wt% template urea molecules were dissolved in 10% EVAL, drop-cast on copper tape, and dried overnight at ambient conditions.

[0101] Subsequently, the MIP-coated copper strips were washed in 50% ethanol solution by gentle shaking for 2 h to remove template urea molecules.

Embodiment 3

[0103] Preparation of MIP membranes for creatinine sensors

[0104] To prepare the working and reference electrodes, 0.1 wt% and 0.05 wt% template creatinine molecules were dissolved in 10% EVAL solution, respectively. The mixture was then coated on isolated copper strips and dried overnight at ambient conditions. The copper strips were then washed with gentle shaking in 50% ethanol solution for 2 hours to remove template creatinine molecules.

[0105] Performance Characterization

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Abstract

The present invention relates to a sensor for detecting one or more target analytes, the sensor comprising: at least one polymeric sensing element capable of selectively and reversibly binding to a target analyte; at least one working electrode having the polymeric sensing element disposed thereon; at least one reference electrode that is electrically communicated with said working electrode; andmeans for measuring a change in an electrical property across said working electrode and said reference electrode. In particular, the target analyte is Na<+>, urea or creatinine. Also disclosed is a multi-layered sensor, comprising at least one working electrode layer and at least one reference electrode layer, said working electrode layer and said reference electrode layer being separated by at least one electrically insulating layer.

Description

technical field [0001] The present invention relates generally to sensors and methods of their use in real-time health screening, monitoring and diagnostic applications. Background technique [0002] Urine is a useful sample for diagnostics and health screening because it can be collected non-invasively in large quantities. In addition, urine is significantly easier to handle and store than tissue biopsies and other body fluids such as whole blood, serum / plasma, and saliva. Urine can be used to detect infection (bacterial and viral), inflammation, cancer (eg bladder cancer) and substance abuse. In particular, urine can be used as an important early indicator of early asymptomatic urinary tract infections (UTIs), kidney disease and diabetes, which are at risk of serious damage if undetected and untreated. For example, abnormally high concentrations of urea and creatinine in urine can predict kidney failure, a global health problem. In addition, the concentration of specifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/333G01N27/327
CPCA61B5/002A61B5/14507A61B5/207A61B5/6808A61F13/42A61F13/84A61F2013/8473G01N27/3275G01N27/333G01N33/493G01N27/327
Inventor 应仪如苏俊珲
Owner AGENCY FOR SCI TECH & RES
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