Making method of fresh digitalis powder and fresh digitalis powder medicinal slices

A kind of technology of fresh Rehmannia glutinosa and Rehmannia glutinosa, applied in the field of traditional Chinese medicine pieces, can solve the problems such as unstable chemical properties and easy loss of catalpol, and achieve the effects of reducing dosage, preventing loss and high relative content

Active Publication Date: 2019-08-13
北京葆年堂(菏泽)药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical properties of catalpol are unstable, and it is easy to lose in processing engineering, so it is hoped to provide a processing method to reduce the loss of catalpol

Method used

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  • Making method of fresh digitalis powder and fresh digitalis powder medicinal slices
  • Making method of fresh digitalis powder and fresh digitalis powder medicinal slices
  • Making method of fresh digitalis powder and fresh digitalis powder medicinal slices

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Embodiment 1 (preparation method)

[0049] Different batches of fresh rehmannia medicinal materials were taken, and fresh rehmannia powder was prepared according to the following steps.

[0050] 1. Put 10kg of rehmannia root medicinal materials collected within 48 hours on the cleaning table in the operation room to remove impurities and non-medicinal parts, and grade them by size. Use a drug washing machine and spray with drinking water until rinsed.

[0051] 2. Powder and juice: Drain the rehmannia glutinosa, cut into large pieces, and put it in a homogenizer to homogenize evenly.

[0052] 3. Weigh β-cyclodextrin according to 0.5% of fresh rehmannia medicinal materials and dissolve it in hot water, add saturated hot water solution of β-cyclodextrin to the homogenized fresh rehmannia juice, stir for 30 minutes, and place at 5°C 5 hours.

[0053] 4. Dry the medicinal material obtained in step 3 in a vacuum freeze dryer, and dry according to the following procedures: ...

Embodiment 2

[0062] Embodiment 2 (preparation method)

[0063] Except that the experimental condition of embodiment 1 is replaced as follows, all the other operate in the same way as embodiment 1:

[0064] Inclusion agent: weigh hydroxypropyl β-cyclodextrin according to 0.15% of fresh rehmannia glutinosa, and prepare 10% hydroxypropyl β-cyclodextrin aqueous solution;

[0065] Mixing method of hydroxypropyl β-cyclodextrin and inclusion agent: power 150W, frequency 18kHz ultrasonic treatment for 30 minutes

[0066] Freeze-drying method: Gradiently lower the temperature of the clathrate solution to -30°C within 2 hours, and pre-freeze; then vacuumize the system to an absolute pressure of 45Pa, slowly heat up to 35°C, and sublimate and dry for 16 hours; then maintain the material temperature 35°C, when the material temperature is close to the heating temperature, the drying ends.

[0067] The prepared fresh rehmannia powder is numbered 2.

Embodiment 3

[0068] Embodiment 3 (preparation method)

[0069] Except that the conditions in Example 1 are replaced as follows, operate in the same way as Example 1,

[0070] Inclusion agent: Weigh gelatin according to 0.25% of fresh rehmannia glutinosa and make 15% gelatin solution;

[0071] Mixing method of gelatin and inclusion agent: power 150W, frequency 18kHz ultrasonic treatment for 60 minutes;

[0072] Freeze-drying method: Gradiently lower the temperature of the inclusion solution to -28°C within 2 hours, and pre-freeze; then vacuumize the system to an absolute pressure of 35Pa, slowly heat up to 30°C, and sublimate and dry for 12 hours; then maintain the material temperature 30°C, when the material temperature is close to the heating temperature, the drying ends, and fresh rehmannia powder 3 is obtained.

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Abstract

The invention provides a making method of fresh digitalis powder and fresh digitalis powder medicinal slices. The making method of the fresh digitalis powder comprises the steps of 1, collecting freshdigitalis, cleaning the fresh digitalis, and obtaining a raw clear material; 2, smashing and juicing the raw fresh digitalis clear material; 3, adding a covering material, and sufficiently mixing thecovering material and digitalis juice; 4, freeze-drying the mixture obtained in step 3; 5 performing micronizing on the freeze-dried medicine. According to the preparation method, the content of catalpa and verbascoside can be kept stable, loss in the drying process is avoided, and the blood cooling effect of the fresh digitalis is reserved basically.

Description

technical field [0001] The invention relates to the field of decoction pieces of traditional Chinese medicine, in particular to a preparation method of fresh rehmannia powder and fresh rehmannia powder decoction pieces. Background technique [0002] According to "Chinese Pharmacopoeia", Rehmannia glutinosa is the fresh or dried root tuber of perennial herb of the genus Rehmannia scrophulariaceae. Excavated in autumn, remove the reed heads, fibrous roots and silt, and use fresh; or slowly bake the rehmannia glutinosa until about 80% dry. The former is commonly called "Fresh Rehmannia", and the latter is commonly called "Raw Rehmannia". Rehmannia glutinosa is a processed product of rehmannia glutinosa. "Chinese Pharmacopoeia" also clearly stipulates that catalpol is an index for the quality control of rehmannia glutinosa. [0003] In addition, as an effective active ingredient in Rehmannia glutinosa, catalpol has various pharmacological effects such as neuroprotection, anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/14A61K47/69
CPCA61K9/14A61K36/804A61K2236/13A61K2236/31A61K2236/51A61K47/6949A61K47/6951
Inventor 周玉新黄艳平
Owner 北京葆年堂(菏泽)药业有限公司
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