Graphene oxide-loaded diclofenac diethylamine and preparation method thereof
A technology based on diclofenac diethylamine and graphene, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problems of difficult control of dosage, easy staining of clothes, limited duration, etc. problems, to overcome low bioavailability, less pollution, slow and stable drug release
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0030] Example 1 Graphene oxide supported diclofenac diethylamine
[0031] (1) Preparation method:
[0032] 1) Dissolve 9 mg of graphene oxide solid in 28 mL of distilled water, and ultrasonically dissolve the graphene oxide solution to be placed in a beaker for use; dissolve 6 mg of diclofenac diethylamine in 2 mL of water, and ultrasonically dissolve to obtain diclofenac diethylamine solution, Under the condition of stirring, the diclofenac diethylamine solution was slowly added dropwise to the graphene oxide solution, and reacted under light shielding at 20°C, and continued stirring at a speed of 30 rpm for 1 hour to obtain a reaction solution;
[0033] 2) Put the reaction solution in step 1) into a 50mL centrifuge tube, centrifuge (5000rpm, 5min) with a high-speed desktop refrigerated centrifuge at 4°C, wash, collect the supernatant, filter it with a 0.45μm organic filter membrane and transfer Put it into a high-performance liquid phase sampling bottle, seal it and store ...
Embodiment 2
[0057] Example 2 Effect of the ratio of graphene oxide and diclofenac diethylamine on the encapsulation efficiency and loading capacity of DDEA / GO
[0058] 1) Weigh 1.8mg, 4.5mg, 6mg, 9mg, and 13.5mg of diclofenac diethylamine respectively and dissolve them in 2mL of distilled water, and slowly add them dropwise to the graphene oxide aqueous solution (oxidized Graphene: 9mg, water: 28mL), light-shielding reaction, continuous stirring for 24h.
[0059] 2) The above reaction solution was centrifuged at 4°C for 10 minutes (5000r / min), the precipitate was washed with water and then centrifuged again (5000rpm, 5min). After repeated washing three times, the precipitate was freeze-dried to obtain the product DDEA / GO, and the supernatant was collected. After filtration with a 0.45 μm organic filter membrane, it was transferred into a high-performance liquid phase sampling bottle, sealed and stored in a refrigerator at 4°C until use.
[0060] 3) Determination by high performance liqui...
Embodiment 3
[0062] Example 3 Effect of reaction time between graphene oxide and diclofenac diethylamine on DDEA / GO encapsulation efficiency and loading capacity
[0063] 1) Weigh eight portions of 6mg diclofenac diethylamine and dissolve them in 2mL of distilled water respectively, and slowly add them dropwise to the graphene oxide aqueous solution (graphene oxide: 9mg, water: 28mL) under stirring (20°C, 30rpm) In the shading reaction, stir for 0min, 5min, 10min, 20min, 30min, 60min, 120min, 180min respectively.
[0064] 2) The above reaction solution was centrifuged at 4°C for 10 minutes (5000r / min), the precipitate was washed with water and then centrifuged again (5000rpm, 5min). After repeated washing three times, the precipitate was freeze-dried to obtain the product DDEA / GO, and the respective supernatants were collected , filtered with a 0.45 μm organic filter membrane, transferred to a high-performance liquid phase sampling bottle, and sealed in a refrigerator at 4°C for storage un...
PUM
| Property | Measurement | Unit |
|---|---|---|
| concentration | aaaaa | aaaaa |
| concentration | aaaaa | aaaaa |
| absorption wavelength | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More