Compound dressing with medicines wrapped and loaded by amnion and microdroplets and preparation method of compound dressing

A technology of encapsulating drugs and micro-droplets, applied in the field of medicine, can solve the problems of non-self-adhesiveness and high cost

Pending Publication Date: 2019-08-16
GUANGDONG PROPHET BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The embodiment of the present invention provides a composite dressing containing amniotic membrane or micro-droplets of drugs and its preparation method, which is used to solve the problem that the existing dressings do not have self-adhesiveness and require auxiliary dressings to fix them, resulting in relatively high costs

Method used

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  • Compound dressing with medicines wrapped and loaded by amnion and microdroplets and preparation method of compound dressing
  • Compound dressing with medicines wrapped and loaded by amnion and microdroplets and preparation method of compound dressing
  • Compound dressing with medicines wrapped and loaded by amnion and microdroplets and preparation method of compound dressing

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Experimental program
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Effect test

Embodiment 1

[0039] Step 101, adding the aqueous solution A containing dextran, trehalose and gelatin to the aqueous solution B containing polyethylene glycol to form a fibril network, and adding a concentration of 0.5 wt% to 1.0 wt% in the fibril network Wt% egg white lysozyme, react at the first set temperature and the first set speed for 10h to 12h to obtain the first water droplets

[0040] Step 102, dissolving the first water micro-droplet with a mass of 20mg-25mg and the slow-release drug with a mass of 0.5mg-1.0mg in an aqueous solution C with a volume of 8ml-10ml according to a mass ratio of 25:1 In the process, react at the second set temperature and the second set speed for 4h to 6h to obtain water micro-droplets encapsulating the slow-release drug;

[0041] Step 103, soak the placenta in amniotic membrane preservation solution containing gentamicin, streptomycin, penicillin and normal saline for 30 minutes, separate the chorion of the placenta after washing, and tile the upper s...

Embodiment 2

[0060] Step 201, adding 1.5wt%, 0.5wt%, and 0.5wt% dextran, trehalose and gelatin solutions to a 6.5wt% polyethylene glycol solution to form a fibril network , and then add 1wt% egg white lysozyme, and react for 10 hours at a temperature of 60° C. with a rotation speed of 100 rpm, thereby forming first water droplets with a diameter of 5 nm.

[0061] Step 202, dissolving 25 mg of the first water micro-droplet and sustained-release drug in a mass ratio of 25:1 in 10 ml of an aqueous solution, reacting for 5 hours at a temperature of 4°C and a rotation speed of 250 rpm, and finally A water micro-droplet encapsulating the slow-release drug is obtained.

[0062] Step 203, soak the placenta with amniotic membrane preservation solution containing penicillin, streptomycin, penicillin and normal saline for 30 minutes, wash several times until the blood on the placenta is washed away, then bluntly separate the amniotic membrane from the chorion of the placenta, and classify The upper ...

Embodiment 3

[0068] Step 301 Preparation of the first water micro-droplets: adding dextran, trehalose, and gelatin with mass percent concentrations of 1.0wt%, 0.1wt%, and 0.1wt% respectively to polyethylene glycol containing 5.5wt% mass percent concentration A fibril network is formed in a solution of diol, and then a percentage concentration of 0.5 wt% egg white lysozyme is added, and the temperature is 65° C. and the rotation speed is 200 rpm, and the reaction is carried out for 12 hours, and the first fiber with a diameter of 5 nm can be prepared. Water water micro-droplets.

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Abstract

The invention relates to the field of medicine, discloses a compound dressing with medicines wrapped and loaded by amnion and microdroplets and a preparation method of the compound dressing and solvesthe problem of high cost of an existing dressing which is lack of self adhesion and requires auxiliary dressing for fixation. The compound dressing comprises a dressing body, the amnion and controlled-release medicine wrapped water-water microdroplets. The controlled-release medicine wrapped water-water microdroplets are adhered on the inner surface of the amnion. The amnion is adhered on the inner surface of the dressing body through the controlled-release medicine wrapped water-water microdroplets.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a composite dressing with amniotic membrane or micro-droplets carrying medicine and a preparation method thereof. Background technique [0002] Medical dressings are medical materials used to cover sores, wounds or other damage. With the in-depth study of the pathophysiology of the wound healing process, people's understanding of the wound healing process has become more and more profound, which has led to the continuous improvement and development of medical dressings. At present, alginate dressing is the most advanced medical dressing in the world. The main component of alginate dressing is alginate, which is a kind of natural cellulose and has no toxicity to the human body. After contact with wound exudate, it can form a soft gel, provide an ideal moist environment for wound healing, promote wound healing, relieve wound pain; and release Ca 2+ , can promote the formation o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/28A61L15/20A61L15/32A61L15/26A61L15/38A61L15/42A61L15/44
CPCA61L15/40A61L15/28A61L15/20A61L15/325A61L15/26A61L15/38A61L15/42A61L15/44A61L2300/602A61L2300/412A61L2300/41C08L5/02C08L71/02
Inventor 周辉
Owner GUANGDONG PROPHET BIOTECHNOLOGY CO LTD
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