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A kind of polyether ether ketone/nanometer hydroxyapatite composite material and its preparation method and application

A technology of nano-hydroxyapatite and polyetheretherketone, which is applied in pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of reduced tensile strength, difficult to meet, and safety of composite materials, and achieve good biological properties. Compatibility and tissue affinity, the effect of solving the reduction of mechanical properties, and excellent mechanical strength

Active Publication Date: 2022-03-01
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing PEEK and hydroxyapatite composite materials prepared by injection molding or thermocompression molding often improve biocompatibility and tissue affinity at the same time, because they do not properly handle the nanoparticles in the matrix. The problem of uniform dispersion in the matrix leads to a large amount of agglomeration of nanoparticles in the matrix. As a result, the mechanical properties of the composite material, especially the tensile strength, are severely reduced, and there are potential safety hazards in clinical applications, so it is difficult to meet the actual requirements of clinical applications.

Method used

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  • A kind of polyether ether ketone/nanometer hydroxyapatite composite material and its preparation method and application
  • A kind of polyether ether ketone/nanometer hydroxyapatite composite material and its preparation method and application
  • A kind of polyether ether ketone/nanometer hydroxyapatite composite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Prepare polyetheretherketone / nanometer hydroxyapatite (acicular) composite material, the specific steps are as follows:

[0044]140 g of polyether ether ketone raw materials were placed in a vacuum drying oven, and dried in vacuum at 120° C. for 12 hours, and sealed for storage after drying. Weigh 60g of acicular nano-hydroxyapatite (acicular nano-hydroxyapatite is 30% of the total mass of polyether ether ketone and acicular nano-hydroxyapatite by mass ratio), pass through a ball mill (ball-to-material ratio 1: 1) Perform blending pretreatment. Adjust the rotational speed of the ball mill to 400 rpm, and mill for 2 hours. Pour the mixed powder premixed by the ball mill into the twin-screw extruder. During the extrusion compounding process, the current of the main machine is maintained at 1-10A, the speed of the main machine is 110rpm, and the feeding speed is 10Hz. The six temperature control zones are 300, 330, 350, 355, 350, 360°C, and the extrusion time is 25 minut...

Embodiment 2

[0047] Prepare polyetheretherketone / nanometer hydroxyapatite (acicular) composite material, the specific steps are as follows:

[0048] 180 g of polyether ether ketone raw material was placed in a vacuum drying oven, and dried in vacuum at 120° C. for 12 hours, and sealed for storage after drying. Weigh 20g of acicular nano-hydroxyapatite (the mass ratio of acicular nano-hydroxyapatite is 10% of the total mass of polyetheretherketone and acicular nano-hydroxyapatite), pass through a ball mill (ball-to-material ratio 1: 1) Perform blending pretreatment. Adjust the rotational speed of the ball mill to 400 rpm, and mill for 2 hours. Pour the mixed powder premixed by the ball mill into the twin-screw extruder. During the extrusion compounding process, the current of the main machine is maintained at 1-10A, the speed of the main machine is 110rpm, and the feeding speed is 10Hz. The six temperature control zones are 300, 330, 350, 355, 350, 360°C, and the extrusion time is 25 minu...

Embodiment 3

[0051] Prepare polyetheretherketone / nano-hydroxyapatite (rod-shaped) composite material, the specific steps are as follows:

[0052] Put 180g of polyether ether ketone raw material in a vacuum drying oven, and dry it under vacuum at 120° C. for 12 hours, and keep it airtight after drying for later use. Weigh 20g rod-shaped nano-hydroxyapatite (rod-shaped nano-hydroxyapatite is 10% of the total mass of polyetheretherketone and rod-shaped nano-hydroxyapatite by mass ratio), and carry out the process by ball mill (ball-to-material ratio 1:1) Blend pretreatment. Adjust the rotational speed of the ball mill to 500 rpm, and mill for 2 hours. Pour the mixed powder pre-mixed by the ball mill into the twin-screw extruder. During the extrusion compounding process, the current of the main engine is maintained at 1-10A, the speed of the main machine is 120rpm, the feeding speed is 10.9Hz, and the six temperature control zones are 300, 330 , 350, 355, 350, 360°C, and the extrusion time w...

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Abstract

The invention discloses a polyether ether ketone / nanometer hydroxyapatite composite material, a preparation method and application thereof. The preparation method is as follows: 1) vacuum drying the polyetheretherketone; 2) pouring the polyetheretherketone dried in step 1) and nano-hydroxyapatite into a ball milling pot for ball milling; The ball-milled mixed powder is poured into the twin-screw extruder, and the polyetheretherketone / nano-hydroxyapatite composite material is obtained by adjusting the current of the main machine, the speed of the main machine, the feeding speed and the six temperature control zones during the extrusion process. The obtained polyetheretherketone / nano-hydroxyapatite composite material has nano-hydroxyapatite dispersed uniformly in polyetheretherketone, which not only has good biocompatibility and tissue affinity, but also has excellent mechanical strength, and can be used It is used in the fields of hard tissue medical implant preparation and medical cosmetology.

Description

technical field [0001] The invention belongs to the field of biological material preparation, and in particular relates to a polyether ether ketone / nanometer hydroxyapatite composite material and a preparation method and application thereof. [0002] technical background [0003] Polyether ether ketone (PEEK) is a high-performance engineering plastics. In addition to its good mechanical properties, stable physical and chemical properties, stability under irradiation, high hydrolysis resistance and thermal stability , can also be used for antibacterial treatment, so it has great application potential as a hard tissue repair material. However, studies have shown that the hydrophobicity and chemical inertness of the surface of pure polyetheretherketone materials make it impossible to effectively combine with biological tissues, and it has strong biological inertness (ie, low tissue compatibility), and its tensile strength is low. , it is difficult to meet the actual application...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/50A61L27/54
CPCA61L27/46A61L27/50A61L27/54A61L2400/12C08L61/16
Inventor 吴庆知余珣知
Owner WUHAN UNIV OF TECH