Collagen-composite calcium phosphate bioceramics and methods of making and using the same

A technology of calcium phosphate ceramics and bioceramics, used in tissue regeneration, prostheses, coatings, etc., to avoid side effects and avoid aseptic inflammation

Active Publication Date: 2021-10-22
SHANGHAI BIO LU BIOMATERIALS
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Therefore there are technical reports to improve the mechanical properties of ceramic materials by material composite technology, and existing research is committed to developing and preparing collagen base or using it as the biomaterial of added phase as the repair of bone tissue, for example, foreign patent (WO93 / 12736) discloses a method for mineralizing collagen as bone tissue repair, but it is only applicable to bone tissue wound repair in non-load-bearing parts

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  • Collagen-composite calcium phosphate bioceramics and methods of making and using the same

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preparation example Construction

[0036] An embodiment of the present invention provides a preparation method of calcium phosphate bioceramic composite collagen, see figure 1 , figure 1 It is a flow chart of the preparation method of the calcium phosphate bioceramic of composite collagen according to an embodiment of the present invention, and the preparation method of the calcium phosphate bioceramic of composite collagen comprises:

[0037] Step S1: Screening required calcium phosphate ceramic particles;

[0038] Step S2: configuring at least one concentration of collagen solution;

[0039] Step S3: According to the order of the concentrations of all the collagen solutions obtained in step S2 from low to high, sequentially use the corresponding concentrations of the collagen solutions to form corresponding cross-linked collagen coatings on the surface of the calcium phosphate ceramic particles , and when the concentration of all the collagen solutions in step S2 is two or more than two, the cross-linked co...

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Abstract

The invention provides a calcium phosphate bioceramic compounded with collagen and its preparation and use method. The preparation method of the calcium phosphate bioceramic compounded with collagen comprises: using collagen solution from low to high concentration on the surface of calcium phosphate ceramic particles Form a cross-linked collagen coating to obtain a cross-linked collagen coating wrapped on the surface of calcium phosphate ceramic particles, then mix with collagen solution and freeze-dry to obtain the precursor of calcium phosphate bioceramic composite collagen, and then use collagen solution to soak Freeze-dry after coating to obtain calcium phosphate bioceramics with collagen coating. The technical solution of the present invention improves the repair ability and degradation performance of the calcium phosphate bioceramics compounded with collagen, avoids aseptic inflammation caused by the shedding of calcium phosphate ceramic particles during clinical use, and utilizes the plasticity of shape and size and The convenience of use solves many problems encountered in the clinical application of bioceramics.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a collagen-composited calcium phosphate bioceramic and a method for preparing and using the same. Background technique [0002] Bioceramics refers to a class of ceramic materials used for specific biological or physiological functions, which are directly used in the human body or in fields related to the human body. As a bioceramic material, it needs to have good biocompatibility, mechanical ratio, affinity with biological tissues and antithrombosis, and have stable physical and chemical properties after sterilization. Calcium Phosphate Bioceramics (CaP) has inorganic components similar to human bone tissue, and has a variety of excellent biological characteristics, so it is widely used in orthopedics, stomatology, ophthalmology, plastic surgery, ENT, brain surgery and Bone tissue repair in tissue engineering and other fields. With the advancement of material manufacturing t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/24A61L27/12A61L27/10A61L27/56A61L27/34
CPCA61L27/10A61L27/12A61L27/24A61L27/34A61L27/50A61L27/56A61L2430/02C08L89/00
Inventor 卢建熙卢霄王臻金芳纯高旭姚宸维
Owner SHANGHAI BIO LU BIOMATERIALS
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