Collagen-composite calcium phosphate bioceramics and methods of making and using the same

Abstract

The invention provides a calcium phosphate bioceramic compounded with collagen and its preparation and use method. The preparation method of the calcium phosphate bioceramic compounded with collagen comprises: using collagen solution from low to high concentration on the surface of calcium phosphate ceramic particles Form a cross-linked collagen coating to obtain a cross-linked collagen coating wrapped on the surface of calcium phosphate ceramic particles, then mix with collagen solution and freeze-dry to obtain the precursor of calcium phosphate bioceramic composite collagen, and then use collagen solution to soak Freeze-dry after coating to obtain calcium phosphate bioceramics with collagen coating. The technical solution of the present invention improves the repair ability and degradation performance of the calcium phosphate bioceramics compounded with collagen, avoids aseptic inflammation caused by the shedding of calcium phosphate ceramic particles during clinical use, and utilizes the plasticity of shape and size and The convenience of use solves many problems encountered in the clinical application of bioceramics.

Description

technical field

[0001] The invention relates to the field of biomedical materials, in particular to a collagen-composited calcium phosphate bioceramic and a method for preparing and using the same. Background technique

[0002] Bioceramics refers to a class of ceramic materials used for specific biological or physiological functions, which are directly used in the human body or in fields related to the human body. As a bioceramic material, it needs to have good biocompatibility, mechanical ratio, affinity with biological tissues and antithrombosis, and have stable physical and chemical properties after sterilization. Calcium Phosphate Bioceramics (CaP) has inorganic components similar to human bone tissue, and has a variety of excellent biological characteristics, so it is widely used in orthopedics, stomatology, ophthalmology, plastic surgery, ENT, brain surgery and Bone tissue repair in tissue engineering and other fields. With the advancement of material manufacturing t...

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