Fruit-flavored pediatric lung-heat cough and asthma suspension drops and preparation method thereof

A technology for children with lung heat, cough and asthma, applied in the field of medicine, can solve problems such as children's resistance to taking, poor taste, and difficult quality control

Inactive Publication Date: 2019-09-06
葵花药业集团北京药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are dosage forms such as Xiaoerfeirekechuan Oral Liquid and Xiaoerfeirekechuan Granules on the market, but most of these preparations have poor taste, large dosage, children resist taking them, and most of the existing oral solutions have precipitation , quality control is more difficult

Method used

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  • Fruit-flavored pediatric lung-heat cough and asthma suspension drops and preparation method thereof
  • Fruit-flavored pediatric lung-heat cough and asthma suspension drops and preparation method thereof
  • Fruit-flavored pediatric lung-heat cough and asthma suspension drops and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Prescription: 200 parts of ephedra, 400 parts of bitter almond, 1600 parts of gypsum, 200 parts of licorice, 668 parts of honeysuckle, 668 parts of forsythia, 668 parts of Anemarrhena, 668 parts of skullcap, 668 parts of Radix Radix, 668 parts of Ophiopogon japonicus, 668 parts of Houttuynia cordata 0.5 parts of preservatives, 0.2 parts of sweeteners, 0.5 parts of mixed fruit flavors, 15 parts of stabilizers (4 parts of xanthan gum, 3 parts of hypromellose, 7 parts of polyvinylpyrrolidone, 1 part of sorbitol).

[0025] Preparation:

[0026] Take the prescribed amount of gypsum, add 4 to 10 times the amount of water and decoct for 0.5 hours, add the rest of ephedra and other ten flavors, add 5 to 10 times the amount of water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate When the relative density is 1.10-1.15 (80°C), let it cool down, add ethanol to make the alcohol content reach 75%; ℃) clear paste. Take the stabiliz...

Embodiment 2

[0028] Prescription: 200 parts of ephedra, 400 parts of bitter almond, 1600 parts of gypsum, 200 parts of licorice, 668 parts of honeysuckle, 668 parts of forsythia, 668 parts of Anemarrhena, 668 parts of skullcap, 668 parts of Radix Radix, 668 parts of Ophiopogon japonicus, 668 parts of Houttuynia cordata 0.5 part of preservative, 0.2 part of sweetener, 0.5 part of grape essence, 15 parts of stabilizer (4 parts of xanthan gum, 3 parts of hypromellose, 7 parts of polyvinylpyrrolidone, 1 part of sorbitol).

[0029] Preparation:

[0030] Take the prescribed amount of gypsum, add 4 to 10 times the amount of water and decoct for 0.5 hours, add the rest of ephedra and other ten flavors, add 5 to 10 times the amount of water to decoct twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate When the relative density is 1.10-1.15 (80°C), let it cool down, add ethanol to make the alcohol content reach 75%; ℃) clear paste. Take the stabilizer and add 2...

Embodiment 3

[0032] Prescription: 200 parts of ephedra, 400 parts of bitter almond, 1600 parts of gypsum, 200 parts of licorice, 668 parts of honeysuckle, 668 parts of forsythia, 668 parts of Anemarrhena, 668 parts of skullcap, 668 parts of Radix Radix, 668 parts of Ophiopogon japonicus, 668 parts of Houttuynia cordata part, 0.5 part of preservative, 0.2 part of sweetener, 0.5 part of peach essence, 15 parts of stabilizer (4 parts of xanthan gum, 3 parts of hypromellose, 7 parts of polyvinylpyrrolidone, 1 part of sorbitol).

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Abstract

The invention belongs to the technical field of medicines and particularly relates to fruit-flavored pediatric lung-heat cough and asthma suspension drops and a preparation method thereof. According to the scientific method, the fruit-flavored pediatric lung-heat cough and asthma suspension drops are prepared from 200 parts of herba ephedrae, 400 parts of semen armeniacae amarum, 1600 parts of gypsum, 200 parts of radix glycyrrhizae, 668 parts of flos lonicerae, 668 parts of fructus forsythiae, 668 parts of rhizoma anemarrhenae, 668 parts of radix scutellariae, 668 parts of radix isatidis, 668parts of radix ophiopogonis, 668 parts of herba houttuyniae, 0.5 part of a preservative, 0.2 part of a sweetening agent, 0.5 part of essences, 15 parts of a stabilizing agent and the balance water, wherein the total parts is 1000. Due to adding of the stabilizing agent, the problem that an original conventional oral liquid is prone to precipitating in long-time placement is avoided, and quality stability and uniformity are improved; in addition, the suspension drops are lower in dosage than the original conventional oral liquid, and by virtue of the fruit-flavored essences, bitterness can beevidently relieved for children, compliance of children to the suspension drops is improved, and curative effects are improved.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a fruit-flavored suspension drop for children with lung-heat cough and asthma and a preparation method thereof. Background technique [0002] Infants with lung heat are mostly caused by heat evils invading the lung guards, causing fever, sweating, slight aversion to wind and cold, cough, yellow sputum, or wheezing, and dry mouth. These are common syndrome types in children, especially in infants and young children. The highest rate, the pathogen is a variety of viruses and bacteria, or its co-infection. Its treatment principle is mainly clearing heat and detoxifying, clearing the lung and resolving phlegm. [0003] At present, there are dosage forms such as Xiaoerfeirekechuan Oral Liquid and Xiaoerfeirekechuan Granules on the market, but most of these preparations have poor taste, large dosage, children resist taking them, and most of the existing oral solutions ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K47/26A61K47/32A61K47/36A61K47/38A61K36/8968A61P11/06A61P11/14A61K33/06
CPCA61K9/0095A61K9/10A61K33/06A61K36/17A61K36/195A61K36/315A61K36/355A61K36/484A61K36/539A61K36/634A61K36/736A61K36/78A61K36/8964A61K36/8968A61K47/26A61K47/32A61K47/36A61K47/38A61K2236/331A61K2236/51A61P11/06A61P11/14A61K2300/00
Inventor 关彦斌付宏伟潘辉
Owner 葵花药业集团北京药物研究院有限公司
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