A naphthoic acid compound in purslane and its extraction and separation method and use

A separation method and compound technology, applied in the separation/purification of carboxylic acid compounds, organic chemistry, drug combination, etc., can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process methods, simple and fast operation methods

Active Publication Date: 2021-12-14
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • A naphthoic acid compound in purslane and its extraction and separation method and use
  • A naphthoic acid compound in purslane and its extraction and separation method and use
  • A naphthoic acid compound in purslane and its extraction and separation method and use

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Embodiment 1

[0027] The invention provides a naphthalene acid compound in purslane, the molecular formulas are C 13 h 12 o 5 , named 4-hydroxy-3,7-dimethoxy-1-naphthoic acid, the chemical structural formula is:

[0028]

[0029] The new compound is named 4-hydroxy-3,7-dimethoxy-1-naphthoic acid according to the structure, and Table 1 is the NMR data of the new compound: 1 H-NMR with 13 C-NMR in DMSO.

[0030] Table 1 NMR data of the new compound 4-hydroxy-3,7-dimethoxy-1-naphthoic acid of the present invention

[0031] Location δ C

Types of δ H ,mult(J in Hz)

1 140.2 C 1-COOH 167.9 C 2 106.9 CH 7.21,s 3 147.3 C 3-OMe 55.9 CH3 3.79,s 4 150.9 C 4a 122.5 C 5 114.9 CH 6.85,d(8.4) 6 123.4 CH 7.43,d(1.8) 7 147.1 C 7-OMe 55.5 CH3 3.80,s 8 112.8 CH 7.44,s 8a 121.6 C

[0032] Structural identification and deduction of a new compound of the present invention,...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from purslane and an extraction and separation method thereof. Described new compound, molecular formula is C 13 h 12 o 5 , named 4-hydroxy-3,7-dimethoxy-1 naphthoic acid. The extraction and separation method of the above-mentioned new compound is also provided, which is sequentially prepared by boiling water, silica gel column chromatography, polyamide column chromatography, ODS medium pressure column and Sephadex LH‑20, and successfully extracts and isolates a new compound . Its structure is identified as a new compound by means of mass spectrum, carbon spectrum, hydrogen spectrum and two-dimensional nuclear magnetic spectrum analysis. The new compound has anti-oxidation and anti-tumor effects. The new compound of the present invention and its salts or derivatives can be used as synthetic leads of other compounds, as well as raw materials for new drug development and pharmacological activity research, for the preparation of anti-tumor, anti-oxidation drugs or health care Taste.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat and detoxification, cooling blood and stopping bleeding, and stoppin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C65/24C07C51/42C07C51/47A61P35/00A61P39/06
CPCC07C65/24A61P35/00A61P39/06
Inventor 英锡相郭胜男张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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