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Application of arsenic trioxide united ascorbic acid to treatment of colon cancer

A technology of arsenic trioxide and ascorbic acid, which is applied in the field of medicine, can solve the problems that the malignant biological characteristics of cancer cells cannot be completely reversed, the proliferation of cancer cells is slowed down, and achieve the effect of reducing toxic and side effects

Inactive Publication Date: 2019-10-08
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Gu Qinlong et al. treated human gastric cancer cell lines SGC7901 and MKN45 with a low concentration of ATO (0.5 μM), and found that the proliferation of cancer cells slowed down and stopped after 16 passages. After 48 hours, the proportion of cells in the G / G0 phase increased and the proportion of cells in the S phase decreased; Therefore, it is believed that low concentration of ATO can induce the differentiation of gastric cancer cell lines, but cannot completely reverse the malignant biological characteristics of cancer cells.

Method used

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  • Application of arsenic trioxide united ascorbic acid to treatment of colon cancer
  • Application of arsenic trioxide united ascorbic acid to treatment of colon cancer
  • Application of arsenic trioxide united ascorbic acid to treatment of colon cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 is used for the preparation of the pharmaceutical preparation (injection) for the treatment of colon cancer

[0024] 1) Take 10g (0.05mol) of arsenic trioxide, 8g of sodium chloride, and 1000mL of water for injection.

[0025] 2) First heat 1000mL of water for injection to boil, add 10g of arsenic trioxide and continue to boil for 30 minutes, add 5.59kg (31.7mol) of ascorbic acid and 8g of sodium chloride when it is completely dissolved, and add water for injection to 1000mL at the same time, filter, can, add Covering, sterilization and other processes can be made. Other items should meet the relevant requirements of the Pharmacopoeia of the People's Republic of China 2000 Edition injection items.

Embodiment 2

[0026] Embodiment 2 is used for the preparation of the pharmaceutical preparation (injection) of colon cancer

[0027] 1) Take 10g (0.05mol) of arsenic trioxide, 8g of sodium chloride, and 1000mL of water for injection.

[0028] 2) First heat 1000mL of water for injection to boil, add 10g of arsenic trioxide and continue to boil for 30 minutes, add 21.93kg (124.5mol) of ascorbic acid and 8g of sodium chloride when it is completely dissolved, and at the same time add water for injection to 1000mL, filter, can, add Covering, sterilization and other processes can be made. Other items should meet the relevant requirements of the Pharmacopoeia of the People's Republic of China 2000 Edition injection items.

Embodiment 3

[0029] Embodiment 3 is used for the preparation of the pharmaceutical preparation (injection) of colon cancer

[0030] 1) Take 10g (0.05mol) of arsenic trioxide, 8g of sodium chloride, and 1000mL of water for injection.

[0031] 2) First heat 1000mL of water for injection to boil, add 10g of arsenic trioxide and continue to boil for 30 minutes, when it is completely dissolved, add 13.2kg (75mol) of ascorbic acid and 8g of sodium chloride, and at the same time add water for injection to 1000mL, filter, can, and cover , sterilization and other processes can be made. Other items should meet the relevant requirements of the Pharmacopoeia of the People's Republic of China 2000 Edition injection items.

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Abstract

The invention discloses an application of arsenic trioxide united ascorbic acid to treatment of colon cancer. Arsenic trioxide and ascorbic acid are in reasonable cooperation, so that the pharmacologic actions of the arsenic trioxide and the pharmacologic action of the ascorbic acid have synergistic actions, the purposes of increasing effects and reducing toxicity are achieved, low-concentration arsenic trioxide can exert the effect of resisting the colon cancer, and the toxic and side effects of the arsenic trioxide in the use process can be alleviated. According to the application disclosedby the invention, a new effective technical means is provided for treatment of the colon cancer, and the arsenic trioxide united ascorbic acid has great application prospect in the field of treatmentof the colon cancer.

Description

technical field [0001] The invention relates to a medicine for treating colon cancer, in particular to the application of arsenic trioxide combined with ascorbic acid in treating colon cancer, and the invention belongs to the technical field of medicine. Background technique [0002] Colon cancer is one of the most common malignant tumors, and the global incidence of colorectal cancer has been soaring. In recent years, colorectal cancer, which occurs frequently every year, has become the third most common malignant tumor in the world, and the incidence of colorectal cancer in my country shows a clear upward trend. At present, the latest global cancer prevalence data has been released. There were about 1.36 million new cases of colorectal cancer in 2012 worldwide, which is the third most common malignant tumor. There were 694,000 deaths from colorectal cancer worldwide, accounting for 10% of all cancer deaths. 8.5%. Colorectal cancer is the third most common cancer in men (...

Claims

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Application Information

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IPC IPC(8): A61K33/36A61P1/00A61P35/00A61K31/375
CPCA61K31/375A61K33/36A61P1/00A61P35/00A61K2300/00
Inventor 杨宝峰初文峰刘宇
Owner HARBIN MEDICAL UNIVERSITY
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